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Preparation method of hydroxylapatite/titanic oxide composite biological coatings

A technology of hydroxyapatite and titanium dioxide, which is applied in coatings, medical science, prostheses, etc., can solve the problems of large particles, poor dispersion, and difficult control of coating uniformity, and achieve high component purity and component uniformity Good, the effect of improving chemical and physical compatibility

Inactive Publication Date: 2009-07-29
NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the HA or TiO2 powder is prepared by other methods, the particles are larger, and the dispersibility of the sol prepared by the precursor salt is worse, which makes it difficult to control the uniformity of the coating

Method used

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  • Preparation method of hydroxylapatite/titanic oxide composite biological coatings
  • Preparation method of hydroxylapatite/titanic oxide composite biological coatings
  • Preparation method of hydroxylapatite/titanic oxide composite biological coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of hydroxyapatite sol, that is, HA sol: triethyl phosphate [(C 2 h 5 O) 3PO] was added to absolute ethanol and diluted according to the molar concentration of triethyl phosphate at 2 mol / L; the pure water with 2.7 times the molar weight of triethyl phosphate was slowly added dropwise to the above diluent for hydrolysis, and a magnetic stirrer was used to Stir vigorously for 24 hours; dry the calcium nitrate at a temperature of 165°C for 36 hours, seal it, and cool it; prepare the calcium nitrate ethanol solution with the dried calcium nitrate at 2mol / L; mix the calcium nitrate ethanol solution with the hydrolyzed triethyl phosphate The esters were mixed in a molar ratio of 5:3, stirred for 3 hours, and aged for 40 hours.

[0036] TiO 2 Preparation of sol: Mix and stir the butyl titanate and ethylene glycol methyl ether solution at a molar ratio of 1:20 for 25 minutes; the molar ratio of ethyl acetoacetate to butyl titanate is 1:5, Then add ethyl acet...

Embodiment 2

[0041] Preparation of HA sol: triethyl phosphate [(C 2 h 5 O) 3 PO] was added to absolute ethanol and diluted according to the molar concentration of triethyl phosphate at 2 mol / L; the pure water with 2.7 times the molar weight of triethyl phosphate was slowly added dropwise to the above diluent for hydrolysis, and a magnetic stirrer was used to Stir vigorously for 24 hours; dry the calcium nitrate at a temperature of 175°C for 32 hours, seal it, and cool it; prepare the calcium nitrate ethanol solution from the dried calcium nitrate at 2mol / L; mix the calcium nitrate ethanol solution with the hydrolyzed triethyl phosphate Mix at a molar ratio of 5:3, stir for 3 hours, and age for 40 hours.

[0042] Preparation of titanium dioxide sol: Mix butyl titanate and ethylene glycol methyl ether solution at a molar ratio of 1:20, and stir for 25 minutes with a magnetic stirrer; the molar ratio of ethyl acetoacetate to butyl titanate is 1:5 , then add ethyl acetoacetate for chelation...

Embodiment 3

[0047] HA sol 0 preparation 0: triethyl phosphate [(C 2 h 5 O) 3 PO] was added to absolute ethanol and diluted according to the molar concentration of triethyl phosphate at 2 mol / L; the pure water with 2.7 times the molar weight of triethyl phosphate was slowly added dropwise to the above diluent for hydrolysis, and a magnetic stirrer was used to Stir vigorously for 28 hours; dry the calcium nitrate at 185°C for 28 hours, seal it, and cool it; prepare the calcium nitrate ethanol solution with 2 mol / L of the dried calcium nitrate; mix the calcium nitrate ethanol solution with the hydrolyzed triethyl phosphate Mixed at a ratio of 5:3, stirred for 3h, and aged for 40h.

[0048] Titanium dioxide sol preparation: mix butyl titanate and ethylene glycol methyl ether solution at a molar concentration ratio of 1:20, stir with a magnetic stirrer for 25 minutes, and then set the molar ratio of ethyl acetoacetate to butyl titanate to 1 : 5, add ethyl acetoacetate for chelation, stir fo...

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Abstract

The invention provides a method for preparing a hydroxyapatite / titanium dioxide composite bioactive coating on the surfaces of medical metals such as a titanium alloy, and the like, and belongs to the technical field of the preparation of bioactive coatings on the surface of the titanium alloy. The composite coating is prepared by preparing precursor sols of HA and TiO2 respectively, then mixing the precursor sols of the HA and the TiO2, and performing aging, coating, drying and heat treatment. The coating has high bioactivity, low cost of preparation technology, and high bonding strength with a matrix, is applicable to the preparation of surface coatings of various complicated geometric structures, and can be used for surface modification of surgical implants such as artificial hip joints and dental implants as well as orthopedic instrument products.

Description

technical field [0001] The invention relates to a method for preparing a hydroxyapatite / titanium dioxide composite biologically active coating on the surface of medical metals such as titanium alloys, and belongs to the technical field of preparing biologically active coatings on the surface of titanium alloys. Background technique [0002] Titanium and alloys, medical stainless steel, etc. are widely used biomedical metal materials, which have good biocompatibility, excellent mechanical properties and corrosion resistance, but their composition is completely different from that of human tissues, and their biomechanical properties are quite different from those of hard tissues. , as a hard tissue implant material, it is only a mechanical interlocking osseointegration with the bone, rather than chemical osseointegration, resulting in poor integration with bone tissue after implantation, often causing implant failure. [0003] Hydroxyapatite HA has the same inorganic material ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/32A61L27/30A61L27/04A61L27/06
Inventor 韩建业于振涛周廉余森
Owner NORTHWEST INSTITUTE FOR NON-FERROUS METAL RESEARCH
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