Method for coating surface of titanium materials and application of coating composite materials

A technology of surface coating and composite materials, applied in coatings, medical science, prostheses, etc., can solve problems such as implant failure, cell inflammation, necrosis, etc., and achieve the effect of promoting cell adhesion

Inactive Publication Date: 2009-12-09
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And the released metal elements can cause inflammatory response or necrosis of cells, leading to implantation failure (Xiong JY, Li YC, Wang XJ, HodgsonP, Wen CE. Mechanical properties and bioactive surface modification via alkaline-heat treatment of a porous Ti-18Nb -4Sn alloy for biomedical applications. Acta Biomaterialia 2008;4:1963-8)

Method used

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  • Method for coating surface of titanium materials and application of coating composite materials
  • Method for coating surface of titanium materials and application of coating composite materials
  • Method for coating surface of titanium materials and application of coating composite materials

Examples

Experimental program
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Effect test

Embodiment 1

[0040] (1) Titanium sheet (10×10×1mm 3 ) were ultrasonically cleaned with deionized water, anhydrous acetone and absolute ethanol in sequence for 30 min each.

[0041] (2) Put the cleaned titanium sheet into 5mol / L NaOH solution, and treat at 80°C for 24h. The titanium sheet was taken out, washed gently with deionized water, and dried in an oven at 40°C.

[0042](3) Put the dried titanium sheet into the furnace at 10°C / min, raise the temperature to 600°C, heat-preserve for 1h, and take out the titanium sheet after the temperature in the furnace is naturally cooled to room temperature.

[0043] (4) Prepare a biomimetic solution (1.5×CSBF) containing 1.5 times of recombinant collagen, weigh the corresponding components in turn, dissolve them in deionized water one by one, adjust the pH to 7.4 with 1M hydrochloric acid, and dilute to 1L.

[0044] (5) Place the titanium sheet treated in step (1) in a 12-well plate, add 5 mL of 1.5×CSBF solution to each well, and let it stand at ...

Embodiment 2

[0047] (1) Titanium sheet (10×10×1mm 3 ) were ultrasonically cleaned with deionized water, anhydrous acetone and absolute ethanol in sequence for 30 min each.

[0048] (2) Put the cleaned titanium sheet into 5mol / L NaOH solution, and treat at 80°C for 24h. The titanium sheet was taken out, washed gently with deionized water, and dried in an oven at 40°C.

[0049] (3) Put the dried titanium sheet into the furnace at 10°C / min, raise the temperature to 600°C, heat-preserve for 1h, and take out the titanium sheet after the temperature in the furnace is naturally cooled to room temperature.

[0050] (4) Prepare a biomimetic solution (1.5×CSBF) containing 1.5 times of recombinant collagen, weigh the corresponding components in turn, dissolve them in deionized water one by one, adjust the pH to 7.4 with 1M hydrochloric acid, and dilute to 1L.

[0051] (5) Place the titanium sheet treated in step (1) in a 12-well plate, add 5 mL of 1.5×CSBF solution to each well, and let it stand at...

Embodiment 3

[0054] (1) Titanium sheet (10×10×1mm 3 ) were ultrasonically cleaned with deionized water, anhydrous acetone and absolute ethanol in sequence for 30 min each.

[0055] (2) Put the cleaned titanium sheet into 5mol / L NaOH solution, and treat at 80°C for 24h. The titanium sheet was taken out, washed gently with deionized water, and dried in an oven at 40°C.

[0056] (3) Put the dried titanium sheet into the furnace at 10°C / min, raise the temperature to 600°C, heat-preserve for 1h, and take out the titanium sheet after the temperature in the furnace is naturally cooled to room temperature.

[0057] (4) Prepare a biomimetic solution (1.5×CSBF) containing 1.5 times of recombinant collagen, weigh the corresponding components in turn, dissolve them in deionized water one by one, adjust the pH to 7.4 with 1M hydrochloric acid, and dilute to 1L.

[0058] (5) Place the titanium sheet treated in step (1) in a 12-well plate, add 5 mL of 1.5×CSBF solution to each well, and let it stand at...

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Abstract

The invention discloses a method for coating the surface of titanium materials, which comprises the following steps: cooling an alkali heat treated titanium disc, putting the titanium disc in a 12-hole plate, respectively adding 5ml of 1.5 times of bionic liquid to each hole, standing the bionic liquid for 2 to 14 days at a temperature of 37 DEG C, and changing 1.5*CSBF liquid every 12h; taking out the titanium disc for washing with deionized water, and naturally drying the titanium disc to acquire a bioactive coating on the titanium surface. The coating is a composite coating of recombined collagen and hydroxyapatite. The coating formed by the method is a composite of nano-hydroxyapatite crystals and the recombined collagen, has two key components of a natural bone, and has the function of promoting cell adhesion, proliferation and differentiation. The prepared titanium composite materials can be applied in bone tissue engineering as bone repair or substitute materials.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a novel coating with good cytocompatibility to osteoblasts by regulating the biomimetic mineralization of the titanium surface through recombinant collagen. The composite material prepared by the method can be used in bone tissue engineering as a bone repair or replacement material. Background technique [0002] Bone tissue is very complex, and its main components are organic collagen and inorganic hydroxyapatite. In addition, there are small amounts of other organic substances, such as proteins, polysaccharides and lipids. From the perspective of materials science, natural bone can be regarded as an elastic polymer-toughened hydroxyapatite-based composite. It is precisely because of the fine and complex structure of bone tissue that clinical treatment of large bone defects is still a difficult research point so far. For many years, the bone repair tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/28A61L27/06A61L27/24A61L27/12
Inventor 姚菊明潘明利蔡玉荣
Owner ZHEJIANG SCI-TECH UNIV
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