Method for preparing biodegradable magnesium alloy surface modification fluoridated hydroxyapatite coating

Abstract

The invention relates to a method for preparing a biodegradable magnesium alloy surface modification fluoridated hydroxyapatite coating. The method comprises the following steps of: pretreating a magnesium alloy substrate, wherein the adopted transfer solution is prepared from sodium dihydrogen phosphate dehydrate and calcium nitrate tetrahydrate; soaking a substrate sample obtained by pretreatment in the transfer solution for 5-100 hours, thus obtaining a calcium-phosphorus coating; soaking a calcium-phosphorus coating sample in an alkali fluoridated transfer solution for 10-48 hours, so as to obtain a fluoridated calcium-phosphorus coating, wherein the alkali fluoridated transfer solution is prepared from sodium hydroxide and sodium fluoride, the concentration of the sodium hydroxide is 3-4g/L, the concentration of the sodium fluoride is 4-5g/L, and heat treatment is not performed; performing heat treatment on the fluoridated calcium-phosphorus coating at the temperature of 300-350 DEG C for 2-5 hours, thus obtaining the fluoridated hydroxyapatite. According to performance detection, the fluoridated hydroxyapatite (FHA) coating prepared by combining a heat treatment process is shaped like a slender sheet and is divergently arranged from the center to the periphery; the electrochemical test proves that the self-corrosion potential of the substrate is improved through the FHA coating; the immersed corrosion experiment proves that an actual protective effect of the FHA coating on the magnesium alloy substrate is better than that of a fluoridated apatite (FA) coating.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable magnesium alloy surface modified fluorinated hydroxyapatite coating. Background technique [0002] In recent years, biomedical degradable materials have attracted widespread attention, and they are mainly used for diagnosing, treating, repairing or replacing damaged tissues and organs of living organisms, and improving their functions. Compared with other kinds of biological materials, the development of biomedical metal materials appears to be relatively slow in recent years. However, metal materials have the advantages of high strength, fatigue resistance, and good forming ability. These properties make medical metal materials still occupy an important position in clinical practice, and metal materials can be better reflected in bones and teeth that need to bear large loads. The advantages. Applied devices are mainly fracture internal fixation plates, screws, artificial joints and roo...

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Problems solved by technology

[0005] However, as a new type of bone tissue engineering material, magnesium alloy material has two important scientific problems in its research and application, which greatly restricts its further development in the medical field, making it impossible to realize the commercialization of medical magnesium alloy.

These two problems are: (1) Material science: too fast degradation of magnesium and its alloys in vivo will also lead to too fast decay of mechanical properties of degradable magnesium alloy bone tissue devices in vivo, which will affect the effect of repair and reconstruction; There is still a lack of research on the material design of degradable magnesium alloys for human applications; the change in the mechanical strength of magnesium alloys during the degradation process in the body is also an important content that needs further research; in view of the special mechanical properties of magnesium alloys compared with other metals, for the use of degradable magnesium alloys The preparation process and technology of degradable magnesium alloy devices also need to be developed and evaluated