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Method for polylactic acid high polymer material surface modified hydroxyapatite coating

A polymer material and hydroxyapatite technology, which is applied in the field of hydroxyapatite coating on the surface of polylactic acid-based polymer materials, can solve the problems of general quality of polylactic acid-based polymer materials, long coating preparation period, and coating Non-uniformity and other problems, to achieve the effect of improving osteoinductivity, shortening the preparation cycle, and being environmentally friendly

Inactive Publication Date: 2012-06-20
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, a layer of hydroxyapatite is biomimetically synthesized on the surface of polylactic acid polymer materials by immersion in simulated body fluids, but there is a disadvantage that the coating preparation cycle is too long, and the obtained coating is not uniform and dense. The quality of the prepared polylactic acid polymer material is average, and the production cost is relatively high

Method used

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  • Method for polylactic acid high polymer material surface modified hydroxyapatite coating
  • Method for polylactic acid high polymer material surface modified hydroxyapatite coating
  • Method for polylactic acid high polymer material surface modified hydroxyapatite coating

Examples

Experimental program
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Effect test

Embodiment 1

[0015] 1. Take poly-L-lactic acid with a molecular weight of 10,000 and wash it with water and ethanol in order;

[0016] 2. Soak the material in 0.01mol / L dopamine aqueous solution (use tri-HCl buffer to adjust PH=8) after activation, and then wash with water once to remove physically adsorbed organic matter;

[0017] 3. Soak the activated material in 0.01mol / L calcium nitrate aqueous solution, take it out and wash it with water once to remove unadsorbed Ca 2+ ion;

[0018] 4. Then, soak in 0.006mol / L diammonium hydrogen phosphate aqueous solution (adjust PH=8 with ammonia water), take it out and wash it with primary water to remove unadsorbed PO 4 3- ion, to dry;

[0019] 5. According to steps 3 and 4, soak 3 times in a cycle to obtain a layer of uniform and dense hydroxyapatite coating.

[0020] The scanning electron microscope pictures of the resulting hydroxyapatite coatings are shown in figure 1 , X-ray diffraction pattern see figure 2 , EDS energy spectrum see ...

Embodiment 2

[0022] 1. Take poly D,L-lactic acid with a molecular weight of 100,000 and wash it with water and ethanol in order;

[0023] 2. Soak the material in 0.5mol / L 2-hydroxyethylamine aqueous solution to activate it, then wash it with water once to remove the physically adsorbed organic matter;

[0024] 3. Soak the activated material in 0.5mol / L calcium chloride aqueous solution, take it out and wash it with water once to remove unadsorbed Ca 2+ ion;

[0025] 4. Then, soak in 0.3mol / L ammonium dihydrogen phosphate aqueous solution (adjust pH=10 with ammonia water), take it out and wash it with water once to remove unadsorbed PO 4 3- ion, to dry;

[0026] 5. According to steps 3 and 4, cycle soaking 20 times to obtain a layer of uniform and dense hydroxyapatite coating.

Embodiment 3

[0028] 1. Take the poly-L-lactic acid-glycolic acid copolymer with a molecular weight of 200,000 and wash it with water and ethanol in order;

[0029] 2. Soak the material in a 1mol / L β-alanine aqueous solution to activate it, then wash it with water once to remove the physically adsorbed organic matter;

[0030] 3. Soak the activated material in 1mol / L calcium hydroxide aqueous solution, take it out and wash it with water once to remove unadsorbed Ca 2+ ion;

[0031] 4. Then, soak in 0.6mol / L disodium hydrogen phosphate aqueous solution (adjust PH=12 with ammonia water), take it out and wash it with primary water to remove unadsorbed PO 4 3- ion, to dry;

[0032] 5. According to steps 3 and 4, soak 50 times in a cycle to obtain a layer of uniform and dense hydroxyapatite coating.

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Abstract

The invention discloses a method for a polylactic acid high polymer material surface modified hydroxyapatite coating, and aims to design a method for the polylactic acid high polymer material surface modified hydroxyapatite coating, which has the advantages of simple and feasible preparation method, low cost and suitability for surface modification of various degradable polylactic acid high polymer material scaffolds. The method for the polylactic acid high polymer material surface modified hydroxyapatite coating comprises the following steps of: soaking a polylactic acid high polymer material with the molecular weight of 10,000-200,000 in an activating solution for activating, covalently introducing -OH, -COOH or -NH2 active groups onto the surface, soaking the activated polylactic acid high polymer material in a Ca<2+> ionic solution, soaking in a PO4<3-> alkaline solution, and repeatedly circulating the steps for 3-50 times to grow a layer of uniform and compact hydroxyapatite coating on the surface of the material finally. The method is environment-friendly, has the advantages that the coating preparation period is short and the cost is low, and is suitable for preparing degradable biological material hydroxyapatite coatings.

Description

Technical field: [0001] The invention relates to a method for modifying the surface of a degradable biomedical material, in particular to a method for modifying a hydroxyapatite coating on the surface of a polylactic acid polymer material. Background technique: [0002] Polylactic acid polymer materials are a kind of environmentally friendly biodegradable biomaterials with good toughness and plasticity, and are often used in the field of bone defect repair. When the artificial bone scaffold prepared by it is implanted into the human body, its osteoinductivity is poor, and its degradation is acidic, which can easily cause inflammation in the body. Too fast degradation speed limits the application of polylactic acid as a tissue fixation and repair material. Hydroxyapatite is the main component of bone and has good biocompatibility and osteoinductivity. According to the osteoinductive theory of "tissue-inducing biomaterials", a layer of hydroxyapatite on the surface of pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/06C08L67/04A61L27/32A61L27/18
Inventor 杨林陶志凯王魁马晓明郭玉明刘涛张培培
Owner HENAN NORMAL UNIV
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