Preparation method of biodegradable magnesium alloy surface-modified hydroxyapatite coating

A hydroxyapatite and surface modification technology, which is applied in the coating process and coating of metal materials, can solve the problems of fast corrosion speed and achieve the goal of improving corrosion resistance, reducing degradation rate and improving biocompatibility Effect

Inactive Publication Date: 2013-12-18
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] On the surface, although many people are optimistic about the application prospects of magnesium alloys

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Cut the ZK60 magnesium alloy into medium-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water and absolute ethanol to ultrasonically clean them. 10min, and dry at room temperature, set aside;

[0022] (2) Configuration of conversion solution: the conversion solution used is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and 1# conversion solution with 0.5Ca / 0.5P is prepared (as shown in Table 1);

[0023] (3) Preparation of the calcium-phosphorus coating: the matrix sample obtained by the pretreatment in step (1) is placed in the conversion solution obtained in the step (2) and soaked for 72 hours to obtain the calcium-phosphorus coating;

[0024] (4) Coating heat treatment: the calcium phosphorus coating that step (3) obtains adopts heat treatment process to prepare hydr...

Embodiment 2

[0027] (1) Cut the ZK60 magnesium alloy into medium-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water and absolute ethanol to ultrasonically clean them. 10min, and dry at room temperature, set aside;

[0028] (2) Configuration of conversion solution: the conversion solution used is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and 1# conversion solution with 0.5Ca / 0.5P is prepared (as shown in Table 1);

[0029] (3) Preparation of the calcium-phosphorus coating: the matrix sample obtained by the pretreatment in step (1) is placed in the conversion solution obtained in the step (2) and soaked for 72 hours to obtain the calcium-phosphorus coating;

[0030] (4) Coating heat treatment: the calcium phosphorus coating that step (3) obtains adopts heat treatment process to prepare hydr...

Embodiment 3

[0033] (1) Cut the ZK60 magnesium alloy into medium-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water and absolute ethanol to ultrasonically clean them. 20min, and dry at room temperature, set aside;

[0034] (2) Configuration of conversion solution: The conversion solution used is prepared from sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate, and the 2# conversion solution of Ca / P is prepared (as shown in Table 1);

[0035] (3) Preparation of the calcium-phosphorus coating: the substrate sample obtained by the pretreatment in step (1) is placed in the conversion solution obtained in the step (2) and soaked for 48 hours to obtain the calcium-phosphorus coating;

[0036] (4) Coating heat treatment: the calcium-phosphorus coating obtained in step (3) is prepared by a heat treatment process to prepar...

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PUM

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Abstract

The invention relates to a preparation method of a biodegradable magnesium alloy surface-modified hydroxyapatite coating. The method specifically comprises the following steps: cutting the magnesium alloy into samples; polishing the samples by aluminum oxide water-resistant abrasive paper to remove surface oxide layers of the magnesium alloy; sequentially ultrasonic-cleaning with deionized water and absolute ethyl alcohol for 5-30 minutes, and drying at room temperature; preparing a conversion liquid by adopting sodium dihydrogen phosphate dihydrate and calcium nitrate tetrahydrate; controlling the molar ratio of calcium and phosphorus at (1:1)-(2:1), the concentration of Ca<2+> at 0.01-0.2M and the P<5+> concentration at 0.01-0.2M; placing pre-treated matrix sample in the conversion liquid to be soaked for 5-100 hours to obtain a calcium and phosphorus coating; preparing the hydroxyapatite coating through the calcium and phosphorus coating by adopting a thermal treatment process: soaking the samples in calcium and phosphorus liquor for 24-72 hours; taking out and directly placing in a Muffle furnace; carrying out thermal treatment at 250-350 DEG C for 2-5 hours; detecting performance. According to the method provided by the invention, the samples taken out from the calcium and phosphorus liquor are placed in the Muffle furnace for direct thermal treatment, so that the method is simpler and easier to operate and control, and the samples can be converted into the hydroxyapatite coating to achieve a considerable corrosion resistant effect.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable magnesium alloy surface modified hydroxyapatite coating. Background technique [0002] Biometal materials currently used in clinic mainly include stainless steel, cobalt-chromium alloy and titanium alloy, etc. These metal materials have good corrosion resistance, but there are also several potential problems, such as poor biocompatibility After entering the body, it is easy to produce toxic ions harmful to the physiological environment due to friction and slight degradation, and because these metal materials generally have good mechanical properties, they will have a stress shielding effect during tissue repair. In addition, their non-degradability, As a result, it needs to be taken out by a second operation, thereby increasing the pain of the patient and the burden of medical expenses. In order to solve the above problems, an important means is to develop biodegradable medical materials...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L31/08C23C22/22C23C22/82
Inventor 陆伟黄平
Owner TONGJI UNIV
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