Titanium or titanium alloy with surface bioactive layer and preparation method thereof

A bioactive, titanium alloy technology, applied in the direction of surface reaction electrolytic coating, superimposed layer plating, coating, etc., can solve the problems of short production cycle, residual stress, long production cycle, etc., to achieve short production cycle, combined High strength and good biological activity

Inactive Publication Date: 2009-09-30
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of the plasma spraying method: high temperature during the spraying process causes partial deterioration of the coated hydroxyapatite, cannot form a firm bond with the substrate, and is prone to degradation in body fluids, etc.
The disadvantage of this method is that the hydroxyapatite layer is formed in simulated human body fluid, the process is slow and the production cycle is long
This method can prepare a thicker hydroxyapatite coating, and the production cycle is short. However, in order to improve the bonding strength of the coating, high-temperature heat treatment is required, which brings additional residual stress due to the difference in thermal expansion coefficient between the coating and the substrate.

Method used

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  • Titanium or titanium alloy with surface bioactive layer and preparation method thereof
  • Titanium or titanium alloy with surface bioactive layer and preparation method thereof
  • Titanium or titanium alloy with surface bioactive layer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] After degreasing with a 5% NaOH aqueous solution at 70°C, the surface of the Ti-6Al-4V sample was polished with 100#, 400#, and 800# silicon carbide sandpaper, cleaned with distilled water, and ultrasonically cleaned at 15kHz in acetone with a concentration of 99.5%. After washing for 5 minutes, blow dry in the air.

[0047] With stainless steel as the cathode and Ti-6Al-4V sample as the anode, oxidize in 0.1mol / L calcium acetate and 0.02mol / L sodium dilight phosphate solution, the voltage is 200V, the time is 60min, after the above oxidation After treatment, the surface of Ti-6Al-4V sample is porous (see attached figure 1 ), through X-ray phase analysis (see attached figure 2 ), the main component of the ceramic membrane is TiO 2 , The porosity of the membrane was 42% as measured by the pore size distribution.

[0048] The oxidized Ti-6Al-4V sample was subjected to the first hydrothermal synthesis treatment. The solution was deionized water, and the pH value was ad...

Embodiment 2

[0053] After degreasing with 5% NaOH aqueous solution at 80°C, the surface of the Ti-6Al-4V sample was polished with 100#, 400#, and 800# silicon carbide sandpaper respectively, cleaned with distilled water, and ultrasonicated at 20kHz in acetone with a concentration of 99.5%. After cleaning for 7 minutes, blow dry in the air.

[0054] With stainless steel as the cathode and Ti-6Al-4V sample as the anode, oxidize in 0.3mol / L calcium acetate and 0.1mol / L sodium dilight phosphate solution, the voltage is 250V, the time is 40min, after the above oxidation After treatment, the surface of the Ti-6Al-4V sample is porous. According to the energy spectrum and X-ray phase analysis, the main component of the ceramic film is TiO 2 , The porosity of the membrane was 46% as measured by the pore size distribution.

[0055] The oxidized Ti-6Al-4V sample was subjected to the first hydrothermal synthesis treatment. The solution was deionized water, and the pH value was adjusted to 11 with NaO...

Embodiment 3

[0060] After degreasing with a 5% NaOH aqueous solution at 90°C, the surface of the pure titanium sample with a mass fraction of 98.50% was polished with 100#, 400#, and 800# silicon carbide sandpaper, and then washed with distilled water. After 8 minutes of medium 25kHz ultrasonic cleaning, blow dry in the air.

[0061] With stainless steel as the cathode and pure titanium sample as the anode, the electrolyte solution formula is 0.1mol / L calcium acetate plus 0.01mol / L β-sodium glycerophosphate, the voltage range is 280V, the time is 30min, the surface of the pure titanium sample It is porous, and according to energy spectrum and X-ray phase analysis, the main component of the ceramic membrane is TiO 2 , The porosity of the membrane was 49% as measured by the pore size distribution.

[0062] The oxidized pure titanium sample was subjected to the first hydrothermal synthesis treatment. The solution was deionized water, and the pH value was adjusted to 12 with NaOH. The reactio...

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Abstract

The invention relates to titanium or a titanium alloy with a surface bioactive layer and a preparation method thereof. In the titanium or the titanium alloy with the surface bioactive layer, the surface bioactive layer is a gradient coating, an inner layer is a ceramic membrane with a porous structure, and an outer layer is a hydroxyapatite coating. The preparation method comprises the following steps that: the titanium or the titanium alloy is subjected to micro-arc anode oxidation to form the porous ceramic membrane containing titanium dioxide and amorphous calcium and phosphorus on the surface; then, hydroxyapatite is synthesized in situ on the surface of the porous ceramic membrane containing the calcium and the phosphorus by using primary hydro-thermal synthesis; and in a secondary hydro-thermal reaction, the existing hydroxyapatite in the coating forms a new core in a hydroxyapatite nucleate to make the coating further grow to finally form the titanium or the titanium alloy with the surface bioactive layer. The preparation method as well as the titanium and the titanium alloy have the advantages of simple manufacturing process, short production period, low cost, high bonding strength of the surface bioactive layer of a product, good bioactivity and the like; and the product can be used for medical implantation.

Description

technical field [0001] The invention relates to a titanium or titanium alloy with a surface bioactive layer and a preparation method thereof. Background technique [0002] Due to its excellent biocompatibility and corrosion resistance, excellent comprehensive mechanical properties and technological properties, titanium alloys occupy an important position in the application of dental implants, artificial joints, spinal orthopedic internal fixation systems, intramedullary nails, orthopedic plates, etc. It has become the material of choice for human hard tissue substitutes and restorations [1, 2]. [1] Jiang Hongjiang, Wang Yulin. Bio-orthopedic materials and clinical research, 2005, 2(4): 28; [2] Yu Yaoting, Wang Lianyong, Wang Shenqi. Development status and countermeasures of biomedical materials. 2002 High-tech Development Report. Beijing: Science and Technology Press, 2003. However, the currently widely used titanium alloys mainly have biological activity problems. As a b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C28/00C23C22/60C25D11/26A61L27/30A61L27/06
Inventor 马凤仓刘平李伟朱坚民杨丽红
Owner UNIV OF SHANGHAI FOR SCI & TECH
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