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Porous, controllable and low-modulus bone defect repair bracket and preparation method thereof

A low modulus, bone defect technology, applied in medical science, electrolytic inorganic material coating, prosthesis, etc., can solve problems such as coating inhomogeneity, achieve good uniformity, solve interface stress problems, and good bone ingrowth effect of ability

Active Publication Date: 2014-04-30
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wang Xiaoxiang et al prepared a strontium-doped hydroxyapatite coating on the surface of titanium with a single structure by electrochemical deposition in direct current mode, but this constant current or constant voltage electrodeposition mode is prone to coating inhomogeneity, especially For porous substrates with complex internal structures

Method used

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  • Porous, controllable and low-modulus bone defect repair bracket and preparation method thereof
  • Porous, controllable and low-modulus bone defect repair bracket and preparation method thereof
  • Porous, controllable and low-modulus bone defect repair bracket and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of titanium alloy scaffold with porosity and controllable low modulus

[0030] Use Unigraphics software to design and build a three-dimensional graphic, the graphic volume is 15mm×15mm×15mm cylinder, input to the selective laser sintering equipment, set a specific laser wavelength, under the protection of argon, use CO 2 The laser beam selectively sinters the Ti6A14V powder (particle diameter is 26μm-53μm). First, the solid part of the powder is sintered, continuously circulated, layer by layer, and the stress is released by wire cutting and heat treatment in the later stage. Finally, ultrasonic cleaning is carried out to remove The powder remains, resulting in a porous scaffold consistent with the desired shape. Each microstructure inside the prepared porous scaffold is a rhombic regular dodecahedron, the diameter of the pore column is 300 μm, the compressive strength is 84 MPa, and the elastic modulus is 3.5 GPa.

[0031] 2. Preparation of Bioactive Co...

Embodiment 2

[0036] 1. Preparation of titanium alloy scaffold with porosity and controllable low modulus

[0037] Use Unigraphics software to design and build a three-dimensional graphic, the graphic volume is 15mm×15mm×15mm cylinder, input to the selective laser sintering equipment, set a specific laser wavelength, under the protection of argon, use CO 2 The laser beam selectively sinters the Ti6A14V powder (particle diameter is 26μm-53μm). First, the solid part of the powder is sintered, continuously circulated, layer by layer, and the stress is released by wire cutting and heat treatment in the later stage. Finally, ultrasonic cleaning is carried out to remove Residual powder. A porous scaffold consistent with the desired shape is obtained. Each microstructure inside the prepared porous scaffold is a rhombic regular dodecahedron, the diameter of the pore column is 300 μm, the compressive strength is 84 MPa, and the elastic modulus is 3.5 GPa.

[0038] 2. Preparation of Bioactive Coati...

Embodiment 3

[0045] 1. Preparation of titanium alloy scaffold with porosity and controllable low modulus

[0046] Use Unigraphics software to design and build a three-dimensional graphic, the graphic volume is 15mm×15mm×15mm cylinder, input to the selective laser sintering equipment, set a specific laser wavelength, under the protection of argon, use CO 2 The laser beam selectively sinters the Ti6A14V powder (particle diameter is 26μm-53μm). First, the solid part of the powder is sintered, continuously circulated, layer by layer, and the stress is released by wire cutting and heat treatment in the later stage. Finally, ultrasonic cleaning is carried out to remove Residual powder. A porous scaffold consistent with the desired shape is obtained. Each microstructure inside the prepared porous scaffold is a rhombic regular dodecahedron, the diameter of the pore column is 300 μm, the compressive strength is 84 MPa, and the elastic modulus is 3.5 GPa.

[0047] 2. Preparation of Bioactive Coati...

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Abstract

The invention discloses a porous, controllable and low-modulus bone defect repair bracket which consists of a porous, controllable and low-modulus titanium alloy bracket and a biological activity coating on the surface of the titanium alloy bracket. The invention further discloses a preparation method of the bone defect bracket. The method comprises the steps that the low-modulus and porous titanium alloy bracket in a controllable internal microstructure is prepared by a quick forming technique; a uniform hydroxyapatite coating and a strontium doped hydroxyapatite coating are prepared on the surface of the bracket in the controllable microstructure; an electrolyte with certain concentration is prepared; a potential is controlled in an electrolytic bath of a three-electrode system; and pulse electrochemical deposition is performed. The elastic modulus of the prepared titanium alloy bracket is equivalent to that of a bone; the prepared hydroxyapatite coating or strontium doped hydroxyapatite coating is combined with a titanium alloy well; the concentration of strontium is controllable; and an implant provided with the biological activity coating can be used for a bone defect of a massive bearing part clinically.

Description

technical field [0001] The invention relates to a medical porous metal support and a preparation method thereof, in particular to a bone defect repair support composed of a porous titanium alloy support and a hydroxyapatite coating or a strontium-doped hydroxyapatite coating deposited on the surface thereof and a preparation method thereof. Background technique [0002] At present, metal titanium and its alloys are widely used as implants in the fields of orthopedics and oral cavity. However, its elastic modulus is relatively high (110GPa), which does not match the elastic modulus of human bone tissue, and it is prone to stress shielding to prevent bone healing. In order to overcome this problem, many scholars have used traditional methods to produce porous metal stents, which have indeed greatly reduced the elastic modulus, but they lack precise control of the internal structure of the pores and the shape of the material, and often cannot meet the medical requirements. pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/06A61L27/56A61L27/54C25D5/18C25D9/04
Inventor 吴志宏鲁雄丁冉谢超鸣邱贵兴吴贵尹博
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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