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Electrochemical preparing method for nano ordered hydroxy apatite coating

An ordered hydroxyapatite and electrochemical technology, applied in the direction of electrolytic inorganic material coating, etc., can solve the problems that the ordered structure of nano-artificial bone materials has not been reported, and achieve the effect of improving biocompatibility and biological activity

Active Publication Date: 2005-03-02
TIANJIN ZHENGTIAN MEDICAL INSTR CO LTD +1
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Problems solved by technology

In recent years, research on the hybridization of hydroxyapatite with collagen and other biological macromolecules to prepare organic / inorganic composite materials has been widely carried out. However, the research on nanoartificial bone materials with ordered structures has not been reported at home and abroad.

Method used

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  • Electrochemical preparing method for nano ordered hydroxy apatite coating
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  • Electrochemical preparing method for nano ordered hydroxy apatite coating

Examples

Experimental program
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Effect test

Embodiment 2

[0017] Embodiment 2: The base material is a pure titanium plate with a thickness of 3 mm, and the surface is mechanically polished to a mirror surface with metallographic sandpaper, cleaned with absolute ethanol and deionized water, and dried for later use; the electrodeposition solution contains 4.2 × 10 -4 mol / LCa(NO 3 ) 2 and 2.5×10 -4 Mole / LNH 4 h 2 PO 4 Electrolyte, using 0.5 mol / LNaNO 3 In order to support the electrolyte, the electrolyte pH=6.00, the control voltage is 3V, the cathodic electrochemical deposition is carried out, the temperature is controlled at 90 ° C, the electrochemical deposition is 1h, and an upright nano-ordered hydroxyapatite deposition layer is obtained on the titanium surface (see figure 1 b), grain size ~100nm.

Embodiment 3

[0018] Embodiment 3: The base material is a pure titanium plate with a thickness of 3mm, and the surface is mechanically polished to a mirror surface with metallographic sandpaper, and cleaned with absolute ethanol and deionized water, and dried for later use; the electrodeposition solution contains 1 × 10 -4 Mole / LCaCl 2 and 0.6×10 -4 Mole / LNaH 2 PO 4 The electrolyte solution, using 0.1 mol / L NaCl as the supporting electrolyte. Electrolyte pH=7.20, control current density to 1mA / cm 2 , carry out cathodic electrochemical deposition, control temperature 100 ℃, electrochemical deposition 1h, obtain microporous nano-ordered hydroxyapatite deposition layer on titanium surface (see figure 1 c), grain size ~60nm.

[0019] Depend on figure 1 It can be seen that the basic structural unit of the electrochemically deposited calcium phosphate film layer is generally acicular crystals, and its grain size varies with the preparation conditions. It can be a larger partial columnar cry...

Embodiment 8

[0021] Example 8: The substrate material is a single crystal silicon wafer sprayed with 500nm titanium, cleaned with absolute ethanol and deionized water, and dried for later use; the electrodeposition solution contains 2.5×10 -4 M Ca(NO 3 ) 2 and 1.5×10 -4 N H 4 h 2 PO 4 Electrolyte, electrolyte pH = 7.0, control current density 5mA cm -2 , for cathodic electrochemical deposition. The temperature was controlled at 70° C., and the electrochemical deposition was performed for 1 h to obtain a nano-ordered hydroxyapatite deposition layer on the titanium surface. Coatings were prepared for in vitro cell culture experiments.

[0022] MG63 human osteosarcoma cells were used for the in vitro cell culture test, and RPMI1640 medium (containing 15% fetal bovine serum, penicillin 100U / ml, streptomycin 100 μg / ml) was used for cell culture in a carbon dioxide incubator (5% CO 2 , 37°C, saturated humidity). The cells were inoculated on the material, cultured in the incubator for two...

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Abstract

The present invention relates to electrochemical deposition process of preparing nanometer ordered hydroxyapatite coating on the surface of medical metal material. Cathode electrochemical deposition onto surface of Ti or Ti alloy is performed with electrodeposition solution containing Ca ion of 1E(-4) to 1E(-3) mol / L and LH2PO4 ion of 0.5E(-4) to 1E(-3) mol / L and in voltage of 1-20 V and current of 0.1-10 mA / sq cm. By means of controlling the electrochemical deposition parameters for forming nanometer hydroxyapatite coating, nanometer hydroxyapatite crystal particles may have different aggregate forms to form different secondary microscopic structures, blossom cluster shaped, upstanding or microspore. The form controllable nanometer hydroxyapatite material is biological material with different topologic structure and homogeneous chemical property, and is expected to have raised biocompatibility and bioactivity in clinical application.

Description

technical field [0001] The invention relates to a method for controllably preparing a nano-ordered hydroxyapatite coating on the surface of a medical metal through electrochemical deposition. Background technique [0002] Natural bone is a composite material composed of an orderly combination of nano-hydroxyapatite (HA)-based inorganic phase and collagen-based organic phase. In bone, the long axis (ie, c-axis) of nano-hydroxyapatite is preferentially arranged along the extension direction of collagen fibers, and this ordered structure ensures maximum mechanical properties. The development of biomedical materials from the perspective of structural bionics and environmentalization is an important direction, and the study of hard tissue replacement materials with structural bionics is an inevitable result of the development of hard tissue replacement materials. In order to study hard tissue substitute materials with the basic characteristics of biological bone, it must firstly...

Claims

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Application Information

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IPC IPC(8): C25D9/08
Inventor 林昌健胡仁时海燕林理文庄燕燕
Owner TIANJIN ZHENGTIAN MEDICAL INSTR CO LTD
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