44 results about "Caffeic acid phenethyl ester" patented technology

Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

The invention discloses a preparation method for catalytic synthesis of caffeic acid phenethyl ester by using lipase in an ionic liquid. The caffeic acid phenethyl ester is enzymatically synthesized in the ionic liquid which is selected as a reaction medium, the solubility of a substrate in the reaction medium is improved, and the thermal stability of the lipase and the stereoselectivity of the lipase to the substrate are improved. The method is easy to operate, is environment-friendly, and contributes to the large-scale preparation of the caffeic acid phenethyl ester, reaction conditions are mild, the yield of products is greatly improved, and the disadvantages that the efficiency of catalytic synthesis of the lipase by a conventional method is low and the solubility of the substrate is low are overcome.

The invention provides a preparation method of a molecularly imprinted polymer capable of enriching caffeic acid phenethyl ester. The molecularly imprinted polymer capable of enriching the caffeic acid phenethyl ester can be prepared through uniformly mixing, nitrogen-blow deoxidization, constant temperature water bath reaction, soxhlet extraction and drying with the caffeic acid phenethyl ester as a template molecule, a mixed solvent of tetrahydrofuran and isooctane as a pore-forming agent, 4-vinyl pyridine as a functional monomer, ethylene glycol dimethacrylate as a crosslinking agent and azodiisobutyronitrile as an initiator. The invention has the advantages that the prepared molecularly imprinted polymer capable of enriching the caffeic acid phenethyl ester has the advantages of simple synthesis, low cost, strong specificity, long service life and the like, can be used for separating and extracting the caffeic acid phenethyl ester from a natural product, in particular to natural products with low caffeic acid phenethyl ester content, and the molecularly imprinted polymer reaches the purposes of enrichment and purification.

The invention relates to applications of a caffeic acid phenethyl ester phenol hydroxyl protecting derivative as shown in a general formula I in preparation of a neuroprotective medicine or a medicine composition for a neurodegenerative disease and in treatment of various types of tumors. In the formula I, the definition of each group is described as the claims in the specification. The invention further relates to a preparation method of the caffeic acid phenethyl ester phenol hydroxyl protecting derivative.

Methods of treating skin diseases such as plaque psoriasis and inverse psoriasis include topical application of one or a combination of caffeic acid phenethyl ester, caffeic acid benzyl ester, and analogs thereof as an active agent. A pharmaceutical composition containing the active agent may further include a cell differentiating agent such as a retinoid, and/or vitamin D or analogs thereof. The method enables treatment of a lesion with active agent dosages of ten percent by weight, for example.

The invention provides a new purpose of caffeic acid and derivatives thereof in preparing drugs of cranial nerves protective agent, wherein caffeic acid methyl ester, caffeic acid ethyl ester and 3, 4-diacetyl caffeic acid obtained by taking the caffeic acid as a raw material which is subject to structural modification have the obvious protective activity for the cranial nerves; the caffeic acid methyl ester and the 3, 4-diacetyl caffeic acid can penetrate a blood brain barrier and directly reaches to a target organ; and the derivatives are ideal candidate medicines of the cranial nerves protective agent.

The invention provides a method for preparing caffeic acid phenethyl ester. The method comprises steps that 3, 4-dihydroxy benzaldehyde and phenylethyl acetate are subjected to microwave irradiation for 1 to 2 hours under catalysis of an organic base in a protic organic solvent to synthesize the caffeic acid phenethyl ester. According to invention, the method has advantages of simple technology, one-step synthesis, cheap and easily-available raw materials, non-toxic sodium alkoxide catalyst and low synthesis cost, the reaction can be carried out at room temperature, a yield is more than 85%, and the method is suitable for industrial production.

The invention provides an effective part of perilla leaf resisting hyperuricemia and a preparation method and application thereof. The effective part takes the perilla leaf as a raw material, and is prepared by the steps of extracting with water, concentrating, ethanol precipitation, reducing pressure, recycling ethanol and obtaining an extractive; performing liquid-liquid partition of n-butyl alcohol and water on the extractive to obtain the separated part of the n-butyl alcohol; purifying the separated part of the n-butyl alcohol by macroporous resin to obtain the effective part of perilla leaf. The sum of the weight of caffeic acid, caffeic acid vinyl ester, rosmarinic acid and methyl rosmarinate accounts for 50 to 70 percent of the effective part, and the effective part contains 5 to 10 percent of scutellarin. A modern separation method and pharmacological activity screening are combined to determine the best effective part, so that the ingredient of the obtained effective part is more clear, the content of the active components is high; the result of experiment in vitro and vivo shows that the effective part of perilla leaf resisting hyperuricemia can inhabit the xanthine oxidase activity to achieve the effect of reducing trioxypurine.

The invention discloses a method for improving the in-vitro fertilization effect of unfrozen pig sperms. The method comprises the following operation steps: (1) taking out frozen sperms, and unfreezing the frozen sperms; (2) cleaning the unfrozen seminal fluid with fertilization operating fluid, centrifuging twice, cleaning centrifugal precipitate with mTBM energetic fluid, centrifuging once, resuspending, and culturing to obtain energetic seminal fluid; (3) picking out a cumulus-oocyte complex from the ovary from which the follicular fluid is extracted under a microscope, culturing, taking out oocytes, and removing the cumulus; and (4) dropwise adding the obtained seminal fluid into each small fertilization cell, putting the small fertilization cells into an incubator for culture, and then washing off sperms attached to the oocytes to finish in-vitro fertilization culture. According to the invention, caffeic acid phenethyl ester and polyvinylpyrrolidone with corresponding concentrations are jointly added into the freezing base solution I, and the caffeic acid phenethyl ester and polyvinylpyrrolidone generate a synergistic effect so that the vitality, plasma membrane integrity rateand DNA integrity rate of the unfrozen pig sperms can be effectively improved, and the in-vitro fertilization effect of the unfrozen pig sperms is further improved.

The invention relates to applications of caffeic acid alkyl ester, wherein the caffeic acid alkyl ester structure is represented by a formula (I), and R is H or C1-C10 alkyl. The present invention provides the applications of the caffeic acid alkyl ester on three gram-positive bacteria, two gram-negative bacteria, and one fungus, wherein the one or a plurality of materials selected from the caffeic acid and the caffeic acid alkyl ester (the alkyl carbon atom number is 1-10) are adopted to inhibit pathogenic bacteria, the effective concentrations for inhibiting the pathogenic bacteria are different, and the low concentration can effectively inhibit the pathogenic bacteria.

The invention relates to a method for producing caffeic acid phenethyl ester by carrying out the enzymatic synthesis of a solvent-free system, which comprises the steps: (1) a 4-type molecular sieve and phenethyl alcohol are placed in a triangular flask according to a mass ratio of 1 to 5 and protected form light; and after shaking on a shaker for 48h, the molecular sieve is removed, thus obtaining anhydrous phenethyl alcohol; (2) caffeic acid reacts with the phenethyl alcohol for 32h to 60h under the catalytic reaction of Novozym 435(lipase from C.antarctica on macroporous acrylic resin) lipase; the mole ratio of the caffeic acid and the phenethyl alcohol is 1: 86 to 1: 96, and reaction temperature is controlled to be 60 DEG C to 70 DEG C; and (3) after reaction, a biological catalyst is removed by filtering; the residual phenethyl alcohol is removed by rotary evaporation, thus obtaining caffeic acid phenethyl ester after the isolation and purification of column chromatography. The synthesizing method of the invention promotes the concentration of substrates and products and reaction selectivity; the yield rate of the caffeic acid phenethyl ester is up to 90 percent approximately; the reaction condition of the method is safe and mild and purification process is easy and has few steps, thus being convenient to industrialized production.

The invention relates to a phenethyl caffeate analogue and preparation and an application thereof in the technical field of medicines. The chemical structure of the phenethyl caffeate analogue is as follows. The method is simple and feasible, higher in yield and suitable for industrialized production on a large scale. The phenethyl caffeate analogue obtained has stronger biological activity and lower effective concentration. Particularly, a compound chlorophenethyl ethyl ester caffeate has a prospect of being developed as a medicine for preventing and treating neurodegenerative diseases.

A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.

The invention provides a method for promoting hematopoietic stem cell homing and implantation, a purpose of caffeic acid phenethyl ester to medicine preparation, a kit for promoting hematopoietic stem cell homing and implantation, and a medicine composition. According to the embodiment, the medicine composition using the caffeic acid phenethyl ester or pharmaceutically acceptable salts of the caffeic acid phenethyl ester as active ingredients has the obvious effect of promoting hematopoietic stem cell homing and implantation.

The invention relates to a method for separating and purifying derivative of pinobanksin and caffeic acid from Chinese propolis aqueous extract. Chinese propolis is used as the raw material and the method comprises the following steps: (1) preparing the Chinese propolis aqueous extract; (2) carrying out alcohol precipitation; (3) carrying out crude separation on the macroreticular resin; and (4) separating and purifying via semi preparation type high performance liquid chromatography. Semi preparation type high performance liquid chromatography is used for separating and purifying, the mobile phase is methanol-water, and four components with high purity can be prepared and are identified to be 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester and caffeic acid phenethyl ester respectively. The technology process is environment-friendly, no serous prejudice is generated to the environment and the comprehensive cost is low.

The invention discloses a drug for treating epstein-barr virus-positive diffuse large B-cell lymphoma (EBV+DLBCL), a drug composition for treating the DLBCL and a drug for treating the DLBCL, wherein the drugs for treating the EBV+DLBCL and the DLBCL are caffeic acid phenethyl ester (CAPE) and derivatives thereof and the drug composition contains the CAPE and the derivatives thereof and cyclophosphamide, hydroxydaunorubicin, oncovino and prednisone or prednisolone) (CHOP). Proved by pharmacological tests, the CAPE has an obvious inhibiting effect on cell proliferation when being used for treating EBV+DLBCL cells and EBV-DLBCL cells; when the CAPE and the CHOP are combined to treat the EBV+DLBCL cells, the sensitivity of the EBV+DLBCL cells to the CHOP is increased by the CAPE; when the CAPE and the CHOP are combined to treat the EBV-DLBCL cells, the sensitivity of the EBV-DLBCL cells to the CHOP is increased by the CAPE; and the CAPE has an obvious inhibiting effect on tumor body growth when being used for treating Farage cell transplantation tumors.

The invention relates to the field of prevention and/or treatment of CAVD. The inventor finds that caffeic acid phenethyl ester (CAPE) can effectively down-regulate the expression of osteogenic differentiation marker genes RUNX2 and ALP in valvular interstitial cells to inhibit the calcification of the valvular interstitial cells, thereby suppressing or delaying the valve calcification; and thus application of caffeic acid phenethyl ester in preparation of the medicine for preventing and/or treating the individual CAVD is provided. Therefore, novel selection is provided for treating the CAVD by using a non-surgical method.

The invention discloses o-nitro caffeic acid phenethyl ester with a structural formula shown as formula I. The method includes: subjecting caffeic acid and thionyl chloride to acylation reaction to generate caffeoyl chloride, then in the presence of a catalyst, subjecting the caffeoyl chloride and o-nitrophenylethanol to esterification reaction in an organic solvent, thus obtaining o-nitro caffeic acid phenethyl ester. Compared with caffeic acid phenethyl ester, the o-nitro caffeic acid phenethyl ester has better effect of protecting antioxidant enzyme activity, stronger ability of clearing oxygen free radicals, and better effects of maintaining antioxidant ability of myocardial cells, protecting normal cell structure and alleviating cell oxidative damage, can significantly reduce ischemia/reperfusion myocardial cell apoptosis, decreases myocardial infarction area, can be used for preparation of drugs for improving ischemia reperfusion injury, and plays an important role in treatment of cardiovascular system diseases. (formula I).

The invention discloses a polymeric natural polyphenol type sunscreen gel. The sunscreen gel comprises caffeic acid phenethyl ester nano particles and a gel substrate, wherein the gel substrate is a mixture of polyvinyl alcohol and water; and the mass percentage of the caffeic acid phenethyl ester nano particles in the gel substrate is 1-12%. The invention further discloses a preparation method ofthe polymeric natural polyphenol type sunscreen gel. The caffeic acid phenethyl ester nano particles in the sunscreen gel are high in stability and low in hematotoxicity and have good oxidation resistance; the preparation method is green, simple and convenient, the synthesis preparation process is not complicated, and the extracted and purified raw materials are all natural.

The invention discloses a sandwich-type microreactor and an application thereof in enzymatic synthesis of caffeic acid phenethyl ester. According to the sandwich-type microreactor disclosed by the invention, lipase Novozym435 is filled into the sandwich-type microreactor and ionic liquid containing caffeic acid methyl ester and phenethyl alcohol as substrates is injected into the microreactor through a micro-injection pump so as to carry out transesterification to prepare caffeic acid phenethyl ester (at 60 DEG C, a flow velocity is 2mu l/min, and when retention time is 2.5 hours, yield is up to 99.5%). The method for preparing the caffeic acid phenethyl ester is simple and convenient to operate, moderate in reaction condition, high in product yield and environment-friendly. According to the sandwich-type microreactor and the application thereof, the shortcomings of a conventional batch reactor which is long in reaction duration, low in synthesis efficiency and the like are overcome, and large-scale preparation of the caffeic acid phenethyl ester is facilitated.

The invention discloses application of caffeic acid phenethylester, a polyphenol component in natural propolis, in preparing of a caries-prevention and anti-caries preparation. The caffeic acid phenethylester has bacteria-inhibiting and bactericidal effects on various cariogenic bacteria including streptococcus mutans, streptococcus sobrinus, streptococcus sanguis, actinomyces viscosus, and lactobacillus acidophilus, can also effectively inhibit formation of a streptococcus mutans biofilm, and reduce the metabolic capacity of a formed biofilm, and has the capability of reducing the amount of lactic acid produced by the streptococcus mutans and reducing the ability to produce exopolysaccharides, thereby achieving caries-prevention and anti-caries functions in various aspects. In addition, and compared with anti-caries propolis, the caffeic acid phenethylester has the advantages that the composition is single, the curative effect is exact, the cost is low, and the caffeic acid phenethylester is easy to popularize and apply in dental care.

The invention discloses an energy-saving thermal insulation building material. The energy-saving thermal insulation building material is prepared from the following raw materials in parts by weight: expanded perlite, coal ash, steel slag powder, slag wool, blast furnace slag powder, clay, diatomaceous earth, dolomite powder, rubber powder, glass fibers, a water reducer, poly(dimethyl diallyl ammonium chloride), poly(ethylene glycol) acrylate, dioctyl sodium sulfosuccinate, polypropylene oxide glycol, caffeic acid phenethyl ester, 8-hydroxyquinoline sulfate, a coagulating material, starch modified polyethylene, a vinyl ketone copolymer, an antioxidant and 3-5 parts of an auxiliary filler. The energy-saving thermal insulation building material has a good thermal insulation effect, the energystorage and temperature regulation functions of the material are achieved, and the loss of indoor heat energy is prevented; and the thermal insulation material takes the expanded perlite as the mainraw material, so that the thermal insulation material has the characteristics of being light in apparent density, low in heat conductivity coefficient, good in chemical stability, non-toxic and odorless.

The invention discloses miRNA (micro Ribonucleic Acid) for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of the miRNA. Research finds that the expression of miR-193a-3p is significantly increased in the kidney tissue subjected to cadmium-induced injury; therefore, the miR-193a-3p can be used as a marker to diagnose the situation of kidney injury of a cadmium-induced organism. Furthermore, the invention also finds that the expression of the miR-193a-3p can be remarkably reduced by intervening the kidney tissue subjected to cadmium-induced injury by using the CAPE. Therefore, it is judged that miR-193a-3p can be used as a miRNA marker for evaluating the cadmium-induced kidney injury resistance of CAPE. According to the invention, the application direction of CAPE is expanded, and a new way is opened up for deeply explaining the protection mechanism of CAPE on kidney injury induced by heavy metals such as cadmium and the like.

The invention discloses an application of caffeic acid phenethylester for preparing a pharmaceutical for reinforcing a learning and memory ability. The effective ingredient of the pharmaceutical for reinforcing the learning and memory ability comprises the caffeic acid phenethylester. A grouping comparison test is executed to ICR mice, and the error frequency of the incubation period and the observation period of the normal ICR mice is counted through a step-down test and a dark avoidance test, so the application field of the caffeic acid phenethylester is broadened.