10 results about "Caffeic acid phenethyl ester" patented technology

The invention discloses the technical field of biological medicine, and particularly relates to application of caffeic acid phenethyl ester in preparation of a ribosome large subunit protein L1 targeted inhibitor. According to the present invention, the drug affinity induced target stability discovers that the ribosome large subunit protein L1 target inhibitor can directly target the ribosome large subunit protein L1 in bacteria, and can be adopted as the competitive inhibitor to competitively combine with the RRF L1 so as to inhibit the ribosome recovery process, such that the bacterial translation process is inhibited, and the bacterial protein synthesis blocking and death are caused. The mechanism enables the ribosome large subunit protein L1 to become a ribosome target with therapeutic potential, provides a new target and theoretical basis for clinical treatment of bacterial infection, and provides new support for screening of new broad-spectrum antibiotics.

The invention discloses a female private care gel with multiple effects and a preparation method thereof. The gel is prepared from the following components: carbomer 980, palmitoyl 3 peptide, phenethyl caffeate, glycerol, pentanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, panthenol, glycerol glucoside, crithmum maritimum callus fermentation filtrate, lysozyme, an ecological nutrient solution and the balance of water. According to the female private care gel disclosed by the invention, through a scientific formula and a reasonable preparation process, the synergistic effect of all the components is fully exerted, the use limitation of palmitoyl 3 peptide in vaginal gel is effectively solved, and the gel can better adapt to the vaginal environment, promote the production of collagen and realize the effects of tightening and moisturizing. Meanwhile, the product has multiple effects of repairing in vitro, moisturizing, relieving, resisting inflammation, regulating flora balance and the like, comprehensively cares female private health, and has a wide market application prospect.

Carbamate-substituted styryl sulfone compounds have a structure of general formula (I). The compounds not only has a significantly enhanced acetylcholinesterase inhibitory activity compared with carbamates as positive drugs, but also has a significantly enhanced therapeutic effect on Parkinson's disease compared with caffeic acid phenethyl ester compounds having similar structures.

The invention provides a honey variety identification method based on amino acid and polyphenol compounds and application of the honey variety identification method, and relates to the technical field of honey variety detection. According to the invention, amino acids and polyphenol compounds in 14 honey varieties are analyzed by adopting a PLS-DA analysis method, and characteristic difference indexes with VIP values greater than 1 are screened out, specifically trans-cinnamic acid, protocatechuic acid, Pro, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 13, 14 According to the method, 2, 4-dimethylcinnamic acid, rosmarinic acid, apigenin, Tyr, vanillic acid, cumaric acid, isoferulic acid, Cys, caffeic acid phenethyl ester, Met, Asp, gallic acid, naringenin, p-cumaric acid, ferulic acid, rhinoceroic acid, chrysin and syringic acid are screened, and then screened characteristic difference index data is used for establishing a linear discrimination model and a random forest prediction model. Through verification, the linear discrimination model and the random forest prediction model constructed by the method can be accurately and efficiently used for discriminating honey varieties.

A method of treating acne, of treating UV or radiation induced injury, of reducing the appearance of scars, and / or of treating mucositis, including topically applying a composition including CAPE to a human or other mammal in need thereof, in a therapeutically effective amount and / or from about 1% to about 50% CAPE by weight.

The invention relates to a caffeic acid phenethyl ester derivative as well as a preparation method and application thereof. The compound provided by the invention is (E)-3-(3, 4-dihydroxyphenyl)-N-phenethyl acrylamide by using an IUPAC standard naming method, has been proved to have a good anti-tumor effect, and can effectively inhibit proliferation of various tumor cells. The invention also relates to a preparation method of the compound and application of the compound in preparation of medicines for preventing and / or treating tumors.

The present invention belongs to the field of biomedicine and specifically relates to the use of caffeic acid phenethyl ester in the preparation of a drug for treating myopia and a pharmaceutical composition thereof. The present invention discovers for the first time that caffeic acid phenethyl ester can promote collagen synthesis in scleral fibroblasts, which are directly related to myopia, inhibit and slow axial elongation and increase in vitreous cavity length in myopic individuals, and increase scleral thickness, thereby delaying and treating myopia. This invention provides a new drug option for the clinical treatment of myopia and has promising application prospects.

Compositions and methods for treating Obstructive Sleep Apnea (OSA)-associated atherosclerosis comprising administering to a subject in need thereof an effective amount of a bile salt hydrolase (BSH) inhibitor such as caffeic acid phenethyl ester

The invention belongs to the field of pharmaceutical preparations. The invention relates to a calcium alginate microsphere containing chitosan oligosaccharide coated bifidobacterium and caffeic acid phenethyl ester nano-enzyme and a preparation method of the calcium alginate microsphere. The calcium alginate microspheres containing the chitosan oligosaccharide coated bifidobacterium and the caffeic acid phenethyl ester nano-enzyme prepared by the preparation method disclosed by the invention can be used for remarkably reducing the uric acid level of rats with gouty arthritis and alleviating the joint swelling of the rats with gouty arthritis.

The invention belongs to the technical field of feeds, and particularly relates to a feed for increasing the content of highly unsaturated fatty acids of largemouth bass, an additive and application of the feed and the additive. By adding the caffeic acid phenethyl ester into the feed, the nutritional value of the feed can be remarkably improved, and breeding feeding experiments prove that the caffeic acid phenethyl ester can activate the activity of Hnf4alpha, promote the expression of highly unsaturated fatty acid synthesis key genes and improve the highly unsaturated fatty acid level of muscular tissues of the micropterus salmoides.