36 results about "Isoferulic acid" patented technology

This invention provides pharmaceutical compositions comprising compounds including 5-phenylpenta-2, 4-dienoic acid, 3-methyl-3-butenyl caffeic acid, 1,1-dimethylallyl caffeic acid, pinobanksin-3-acetate, tectochrysin, pinostrobin chalcone, benzyl ferulate and benzyl isoferulate. Methods of using such compositions, in particular in the treatment or prevention of gastrointestinal cancers, and the resensitisation of gastrointestinal cancers to therapy are also provided.

The invention discloses a detection method of a Qingjin Qi-tonifying composition and a fingerprint construction method of the Qingjin Qi-tonifying composition. The detection method of the Qingjin Qi-tonifying composition comprises the following steps: S1, preparing isoferulic acid, hesperidin and ammonium glycyrrhizinate: a, preparing a mixed reference solution; b, preparing a test solution; c, preparing a negative composition solution; d, determining chromatographic conditions; and e, respectively injecting the solutions into a liquid chromatograph, and determining to obtain the target product. S2, preparing verbenin, verbenin, baicalin and wogonoside of the radix morindae officinalis; a, preparing a mixed reference substance solution; b, preparing a test solution; c, preparing a negative composition solution; d, determining chromatographic conditions; and e, respectively injecting the solutions into a liquid chromatograph, and determining. According to the detection method of the Qingjin Qi-tonifying composition, quality control is conducted on the Qingjin Qi-tonifying composition, and it is guaranteed that medication of a patient is safe, reliable and effective.

The invention discloses an ASE method for extracting isoferulic acid in Cimicifuga, which comprises the following steps: step 1: pulverize Cimicifuga, and sieve; Step 2: weigh 0.5 parts by weight of Cimicifuga powder, and Parts of quartz sand are mixed evenly for use; step 3: add an appropriate amount of quartz sand to the extraction pool with the filter membrane in advance until reaching the pool mouth of the extraction pool; cover the lid of the extraction pool for static extraction; obtain the extract after the extraction is completed, The extraction conditions are as follows: the extraction solvent is 40% methanol; the extraction temperature is 120°C; the static extraction time is 5 minutes; the washing volume is 60%; the number of static cycles is 4 times; the 40% methanol is 40% by volume of methanol. The invention provides an ASE method for extracting isoferulic acid in Cimicifuga, which is simple in operation and high in detection accuracy.

The invention belongs to the technical field of cosmetics, and specifically relates to an antiseptic composition for cosmetics and a preparation method thereof, which comprises the following components in parts by weight: 1-10 parts of pistachio extract, 1 ~10 parts, 1~8 parts of isoferulic acid, 3~20 parts of polyols and 40~60 parts of deionized water. The antiseptic composition provided by the present invention is composed of pistachio extract, Phyllostachys spp. extract and isoferulic acid. The antibacterial spectrum of a single component, the above-mentioned active ingredients are all natural ingredients, low skin allergy, and wide pH tolerance (3-9), can be used in various skin care products, cosmetics or cosmeceuticals.

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepared by carrying out structural modification on 4,7-diacetyl isoferulic acid genistein, 7-2-bromo-ethoxy genistei and a genistein vanadyl complex. Results of administration hypoglycemic activity screening and cell activity experiments show that the composition has a very good hypoglycemic effect which is better that that of single compounds, and can be used for preparing medicine for treating type II diabetes.

The invention provides a medicinal composition for preventing vascular thrombosis diseases. The medicinal composition consists of 4 to 16 parts of ferulic acid, 2.5 to 10 parts of protocatechuic acid,3 to 12 parts of p-coumaric acid, and 2 to 8 parts of isoferulic acid. The antithrombotic titer of the medicinal composition prepared in the invention can reach 96.66 percent. The medicinal composition of the invention comprises no toxic ingredient 5-hydroxymethyl furfural, the potential toxic harm of rhizoma sparganii crude drugs on the inheritance and reproduction of human bodies can be avoided, the medicinal composition is safe to use, and the curative effect is improved; finally, a foundation is set for further developing novel active ingredient composition preparations.

The invention discloses the application of phenylacrylic compounds to the preparation of Shp2-specific inhibitors and pharmaceutical application thereof. The invention finds that two phenylacrylic compounds, namely isoferulic acid and cinnamic acid, have a specific inhibitory effect on Shp2 and the isoferulic acid and the cinnamic acid can be prepared into the Shp2-specific inhibitors. The invention further verifies that both the isoferulic acid and the cinnamic acid can inhibit EGF-induced phosphorylation of Erk by inhibiting the activity of the Shp2 in the cellular level, the cinnamic acid can also inhibit EGF-induced migration of MDA-MB-468 cells, and the isoferulic acid and the cinnamic acid are expected to be developed into medicines for preventing or treating of Shp2-related diseasesand are of a great significance on the development of the medicines targeting the Shp2.

The invention discloses TCM (traditional Chinese medicine) tooth stain removing toothpaste. The effective components for removing the tooth stains account for 4% to 10% of the total composites of the toothpaste body by weight ratio and comprise the TCM extracts of cimicifugae foetidae, ligusticum and angelica root with the raw drug ratio of cimicifugae foetidae:ligusticum:angelica root being 1:1:1, wherein the weight percentage of ferulic acid is higher than or equal to 0.001% in the total composites of the toothpaste body; the weight percentage of isoferulic acid is higher than or equal to 0.001% in the total composites of the toothpaste body; and the weight percentage of imperatorin is higher than or equal to 0.0005% in the total composites of the toothpaste body. The tooth stain removing toothpaste is capable of effectively removing tooth exogenous stains and other exogenous stains from teeth and protecting the oral mucosa and has the advantages of low irritation, safe use, wide material source and low manufacturing cost.

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating women's climacteric syndrome, its preparation method and its application in treating climacteric syndrome. The raw material medicine composition of the composition is Cimicifuga: puerariae: red peony: roasted licorice at a ratio of 1:1 to 1.5:1:1. The preparation method of the extract of the composition is a conventional water decoction and alcohol precipitation process, or ethanol immersion, reflux, filtration to remove residue, filtrate to stand still, further filtration to remove residue, recovery of ethanol, drying and crushing to obtain the product. The extract of the composition contains effective active ingredients such as acteoside, isoferulic acid, puerarin, paeoniflorin, glycyrrhizic acid, glycyrrhetinic acid, liquiritin and the like. The extract obtained from the traditional Chinese medicine composition of the present invention has a significant therapeutic effect on the climacteric syndrome model caused by castrated female rats, can significantly increase the uterine wet weight and uterine coefficient of the model rats, and inhibit the abnormal increase in the body temperature of the model rats. High, and have obvious recovery and regulation effects on estrogen levels such as E2, FSH, LH.

The invention provides a medicinal composition for preventing vascular thrombosis diseases. The medicinal composition consists of 4 to 16 parts of ferulic acid, 2.5 to 10 parts of protocatechuic acid,3 to 12 parts of p-coumaric acid, and 2 to 8 parts of isoferulic acid. The antithrombotic titer of the medicinal composition prepared in the invention can reach 96.66 percent. The medicinal composition of the invention comprises no toxic ingredient 5-hydroxymethyl furfural, the potential toxic harm of rhizoma sparganii crude drugs on the inheritance and reproduction of human bodies can be avoided, the medicinal composition is safe to use, and the curative effect is improved; finally, a foundation is set for further developing novel active ingredient composition preparations.

The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule / potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

The invention discloses a quality detection method of asiatic toddalia root gargle, comprising the following steps of: (1) identifying the asiatic toddalia root gargle; and (2) measuring the content according to a high-efficiency liquid chromatography: A, performing of a chromatograph condition and system adaptability test; B, comparison product solution preparation: precisely weighting a proper amount of isoferulic acid comparison product and preparing into the solution containing 20 mug per 1ml by using 10% ethanol; C, preparation of a test sample solution; and D, application of a measuringmethod: precisely absorbing 10 mul of the comparison production solution and 10 mul of the test sample solution, injecting in a liquid chromatograph for measuring, wherein every 100ml of the product contains at least 4.0mg of rhizoma cimicifugae metered by isoferulic acid. The invention has high test accuracy, can better control the quality of the medicine and ensure the medication safety, and the medicinal materials can be easily obtained.

The invention relates to a compound combination with an effect of synergistically scavenging radicals. Active trace detection is carried out by adopting a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay; the synergistic effects (combination coefficient, CI) of two groups of antioxidant ingredients are evaluated by adopting a dose-effect analysis method on the basis of a median effect principle; a group of compounds for synergistically scavenging the radicals, namely calycosin and isoferulic acid are screened from astragalus membranaceus and cimicifugae foetidae; methanol solutions of the calycosin and the isoferulic acid are combined according to different dose ratios (3:1, 2:1, 1:1, 1:2, or 1:3), so as to determine the DPPH radical scavenging capacity. Thus, the calycosin and the isoferulic acid display the best synergistic effect under the condition that the dose ratio is 1:1.