39 results about "Isoferulic acid" patented technology

The invention relates to a compound combination with an effect of synergistically scavenging radicals. Active trace detection is carried out by adopting a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay; the synergistic effects (combination coefficient, CI) of two groups of antioxidant ingredients are evaluated by adopting a dose-effect analysis method on the basis of a median effect principle; a group of compounds for synergistically scavenging the radicals, namely calycosin and isoferulic acid are screened from astragalus membranaceus and cimicifugae foetidae; methanol solutions of the calycosin and the isoferulic acid are combined according to different dose ratios (3:1, 2:1, 1:1, 1:2, or 1:3), so as to determine the DPPH radical scavenging capacity. Thus, the calycosin and the isoferulic acid display the best synergistic effect under the condition that the dose ratio is 1:1.

The invention discloses a quality detection method of asiatic toddalia root gargle, comprising the following steps of: (1) identifying the asiatic toddalia root gargle; and (2) measuring the content according to a high-efficiency liquid chromatography: A, performing of a chromatograph condition and system adaptability test; B, comparison product solution preparation: precisely weighting a proper amount of isoferulic acid comparison product and preparing into the solution containing 20 mug per 1ml by using 10% ethanol; C, preparation of a test sample solution; and D, application of a measuring method: precisely absorbing 10 mul of the comparison production solution and 10 mul of the test sample solution, injecting in a liquid chromatograph for measuring, wherein every 100ml of the product contains at least 4.0mg of rhizoma cimicifugae metered by isoferulic acid. The invention has high test accuracy, can better control the quality of the medicine and ensure the medication safety, and the medicinal materials can be easily obtained.

The invention belongs to the technical field of cosmetics, and particularly relates to a moisturizing and skin-refreshing mask and a preparation method thereof. The mask comprises the following components in parts by weight: cassava gelatinized starch, soybean protein, carbomer, aloe extract, seaweed extract, chamomile extract, hydroxyethyl cellulose, glycerol, calcium hydroxide, preservative composition and deionized water. The moisturizing and skin-refreshing mask provided by the invention is prepared from the food-grade cassava gelatinized starch, and is high in safety, soft in texture andgood in skin application property; the aloe extract, the seaweed extract and the like are added as moisturizing components, so that the mask is endowed with an excellent moisturizing effect, the skinis smoother and more elastic after the mask is used, and fine wrinkles are reduced; the preservative composition composed of pistachio extract, phellinus linteus extract and isoferulic acid is added into the mask, so that the mask is endowed with a good anti-corrosion effect, and the anti-corrosion components are all natural plant components and low in allergenicity on skin, and remarkably prolongs the shelf life of the mask.

The invention discloses a determination method for isoferulic acid in Rhizoma Cimicifugae. The method comprises the following steps: step 1, crushing Rhizoma Cimicifugae and then extracting the crushed Rhizoma Cimicifugae by using an ASE extraction method so as to obtain extract; step 2, subjecting the extract obtained in the previous step to centrifugation so as to obtain supernatant; and step 3, analyzing the supernatant by using liquid chromatography. The determination method for isoferulic acid in Rhizoma Cimicifugae is simple to operate and high in detection precision.

The invention discloses the application of phenylacrylic compounds to the preparation of Shp2-specific inhibitors and pharmaceutical application thereof. The invention finds that two phenylacrylic compounds, namely isoferulic acid and cinnamic acid, have a specific inhibitory effect on Shp2 and the isoferulic acid and the cinnamic acid can be prepared into the Shp2-specific inhibitors. The invention further verifies that both the isoferulic acid and the cinnamic acid can inhibit EGF-induced phosphorylation of Erk by inhibiting the activity of the Shp2 in the cellular level, the cinnamic acid can also inhibit EGF-induced migration of MDA-MB-468 cells, and the isoferulic acid and the cinnamic acid are expected to be developed into medicines for preventing or treating of Shp2-related diseasesand are of a great significance on the development of the medicines targeting the Shp2.

The invention discloses TCM (traditional Chinese medicine) tooth stain removing toothpaste. The effective components for removing the tooth stains account for 4% to 10% of the total composites of the toothpaste body by weight ratio and comprise the TCM extracts of cimicifugae foetidae, ligusticum and angelica root with the raw drug ratio of cimicifugae foetidae:ligusticum:angelica root being 1:1:1, wherein the weight percentage of ferulic acid is higher than or equal to 0.001% in the total composites of the toothpaste body; the weight percentage of isoferulic acid is higher than or equal to 0.001% in the total composites of the toothpaste body; and the weight percentage of imperatorin is higher than or equal to 0.0005% in the total composites of the toothpaste body. The tooth stain removing toothpaste is capable of effectively removing tooth exogenous stains and other exogenous stains from teeth and protecting the oral mucosa and has the advantages of low irritation, safe use, wide material source and low manufacturing cost.

This invention provides pharmaceutical compositions comprising compounds including 5-phenylpenta-2, 4-dienoic acid, 3-methyl-3-butenyl caffeic acid, 1,1-dimethylallyl caffeic acid, pinobanksin-3-acetate, tectochrysin, pinostrobin chalcone, benzyl ferulate and benzyl isoferulate. Methods of using such compositions, in particular in the treatment or prevention of gastrointestinal cancers, and the resensitisation of gastrointestinal cancers to therapy are also provided.

The invention discloses a detection method of a Qingjin Qi-tonifying composition and a fingerprint construction method of the Qingjin Qi-tonifying composition. The detection method of the Qingjin Qi-tonifying composition comprises the following steps: S1, preparing isoferulic acid, hesperidin and ammonium glycyrrhizinate: a, preparing a mixed reference solution; b, preparing a test solution; c, preparing a negative composition solution; d, determining chromatographic conditions; and e, respectively injecting the solutions into a liquid chromatograph, and determining to obtain the target product. S2, preparing verbenin, verbenin, baicalin and wogonoside of the radix morindae officinalis; a, preparing a mixed reference substance solution; b, preparing a test solution; c, preparing a negative composition solution; d, determining chromatographic conditions; and e, respectively injecting the solutions into a liquid chromatograph, and determining. According to the detection method of the Qingjin Qi-tonifying composition, quality control is conducted on the Qingjin Qi-tonifying composition, and it is guaranteed that medication of a patient is safe, reliable and effective.

The invention discloses an ASE method for extracting isoferulic acid in Cimicifuga, which comprises the following steps: step 1: pulverize Cimicifuga, and sieve; Step 2: weigh 0.5 parts by weight of Cimicifuga powder, and Parts of quartz sand are mixed evenly for use; step 3: add an appropriate amount of quartz sand to the extraction pool with the filter membrane in advance until reaching the pool mouth of the extraction pool; cover the lid of the extraction pool for static extraction; obtain the extract after the extraction is completed, The extraction conditions are as follows: the extraction solvent is 40% methanol; the extraction temperature is 120°C; the static extraction time is 5 minutes; the washing volume is 60%; the number of static cycles is 4 times; the 40% methanol is 40% by volume of methanol. The invention provides an ASE method for extracting isoferulic acid in Cimicifuga, which is simple in operation and high in detection accuracy.

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepared by carrying out structural modification on 4,7-diacetyl isoferulic acid genistein, 7-2-bromo-ethoxy genistei and a genistein vanadyl complex. Results of administration hypoglycemic activity screening and cell activity experiments show that the composition has a very good hypoglycemic effect which is better that that of single compounds, and can be used for preparing medicine for treating type II diabetes.

The invention belongs to the technical field of cosmetics, and particularly relates to a whitening and spot-fading mask and a preparation method thereof. The mask takes tricholoma matsutake extract, acacia farnesiana extract, pentapeptide, rehmannia extract and dipotassium glycyrrhizinate composite watercress extract as functional components, can effectively solve the problems of dark and gloomy skin, color spots and the like, and makes the skin moisturized and whiter; and meanwhile, a preservative composition consisting of pistachio extract, phellinus linteus extract and isoferulic acid is added into the mask disclosed by the invention. The preservative composition has a remarkable inhibition effect on various common contaminating bacteria in cosmetics, the effective components are all natural plant components, the skin sensitization is low, the pH capacity limit value is wide (3-9), and the shelf life of the mask is remarkably prolonged.

The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule / potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

The invention discloses environment-friendly latex paint which comprises the raw materials in parts by weight: 2-4 parts of polyester polyurethane, 1-2 parts of n-butyl acetate, 2-3 parts of trimethyl hexamethylene diisocyanate, 1-3 parts of organic siloxane, 2-4 parts of hydrophobic dioxide, 1-2 parts of polyoxyethylene polyoxypropylene pentaerythritol ether, 2-5 parts of p-hydroxybenzaldehyde, 1-4 parts of m-hydroxybenzoic acid, 1-2 parts of ergosterol, 1-3 parts of isoferulic acid, 0.1-0.2 part of essence, 2-5 parts of 3-hydroxyl-4-methoxyl acetophenone and 2-4 parts of carboxyl benzoic acid. The environment-friendly latex paint is not only health, environment-friendly and convenient to use, convey and store, but also free from any preservatives, and nontoxic, fast in drying, and further leaves odor lastingly and purifies air.

The invention relates to a method for separating and purifying caffeic acid, ferulic acid and isoferulic acid from a Chinese propolis aqueous extract. The method adopts Chinese propolis as a raw material, and comprises the following steps: (1) preparing a Chinese propolis aqueous extract; (2) precipitating with alcohol; (3) coarsely separating with macroporous adsorption resin; and (4) separating and purifying by semi-preparative high performance liquid chromatography. According to the method, the semi-preparative high performance liquid chromatography is used for separating and purifying, a mobile phase is methanol-water, and three kinds of high-purity ingredients, which are identified to be caffeic acid, ferulic acid and isoferulic acid respectively, are obtained. The method is green and environment-friendly in process, does not have serious damage to the environment, and has low comprehensive cost.

The invention belongs to the technical field of cosmetics, and specifically relates to an antiseptic composition for cosmetics and a preparation method thereof, which comprises the following components in parts by weight: 1-10 parts of pistachio extract, 1 ~10 parts, 1~8 parts of isoferulic acid, 3~20 parts of polyols and 40~60 parts of deionized water. The antiseptic composition provided by the present invention is composed of pistachio extract, Phyllostachys spp. extract and isoferulic acid. The antibacterial spectrum of a single component, the above-mentioned active ingredients are all natural ingredients, low skin allergy, and wide pH tolerance (3-9), can be used in various skin care products, cosmetics or cosmeceuticals.

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepared by carrying out structural modification on 4,7-diacetyl isoferulic acid genistein, 7-2-bromo-ethoxy genistei and a genistein vanadyl complex. Results of administration hypoglycemic activity screening and cell activity experiments show that the composition has a very good hypoglycemic effect which is better that that of single compounds, and can be used for preparing medicine for treating type II diabetes.

The invention provides a medicinal composition for preventing vascular thrombosis diseases. The medicinal composition consists of 4 to 16 parts of ferulic acid, 2.5 to 10 parts of protocatechuic acid,3 to 12 parts of p-coumaric acid, and 2 to 8 parts of isoferulic acid. The antithrombotic titer of the medicinal composition prepared in the invention can reach 96.66 percent. The medicinal composition of the invention comprises no toxic ingredient 5-hydroxymethyl furfural, the potential toxic harm of rhizoma sparganii crude drugs on the inheritance and reproduction of human bodies can be avoided, the medicinal composition is safe to use, and the curative effect is improved; finally, a foundation is set for further developing novel active ingredient composition preparations.

The invention discloses a skin whitening, brightening and repairing composition containing active polypeptide and application of the skin whitening, brightening and repairing composition, and relates to the field of cosmetics. The skin whitening, brightening and repairing composition containing the active polypeptide comprises an active polypeptide compound and a functional active substance, the active polypeptide compound comprises but is not limited to antioxidant polypeptide, inflammatory factor release inhibiting polypeptide, collagen supplementing polypeptide and skin brightening polypeptide; the functional active substance comprises but is not limited to one or more of isoferulic acid and isoferulic acid amide derivatives; the isoferulic acid amide derivative at least comprises adenosine and an epoxy alkyl group. The composition provided by the invention has multiple skin repairing effects, and the skin improving effect is better; wherein the whitening effect is obviously enhanced, and the anti-wrinkle capability is obviously improved; and meanwhile, the antioxidant and anti-allergic repair capabilities are better.

The invention discloses a method for extracting isoferulic acid from radix clematidis. The extraction method comprises the following steps: crushing the radix clematidis, performing sieving by a 40-80-mesh sieve, weighing radix clematidis powder, adding the weighed radix clematidis powder into an organic solvent, wherein a mass-to-volume ratio of the radix clematidis powder to the organic solventis 1 g:(10-20) mL, performing heating reflux extraction, wherein the extraction temperature is 60-100 DEG C, the extraction time is 30-120 min and the extraction times are 1-3 times, merging the extraction liquids, performing filtration, and performing concentration on the filtered extraction liquid to dryness to obtain crude isoferulic acid extract. The method provided by the invention has the advantages of simple operation, good repeatability and good stability; and only ethyl acetate, ethanol, glycerin, lactic acid, citric acid, glacial acetic acid, formic acid, methanol and acetonitrile are used in the processes of extraction, separation and purification, organic solvents such as chloroform and benzene which are harmful to the environment and human bodies are not used, so that the method is safe, green and environmentally friendly in the whole process, and opens up a novel way to obtain the isoferulic acid.

The invention provides a traditional Chinese medicine active ingredient composition for improving migraine through nasal administration. The traditional Chinese medicine active ingredient composition comprises the following traditional Chinese medicine active ingredients: tetrahydrojateorhizine, scopoletin, ferulic acid, isoferulic acid, piperlongumine and piperine. The invention also provides application of the traditional Chinese medicine active ingredient composition, and the traditional Chinese medicine active ingredient composition is used for preparing medicines for improving migraine through nasal administration. The traditional Chinese medicine active component composition can significantly inhibit LPS-induced BV2 nerve cell inflammation, and can be used for preparing drugs for improving migraine through nasal administration.

The invention discloses the application of phenylacrylic compounds to the preparation of Shp2-specific inhibitors and pharmaceutical application thereof. The invention finds that two phenylacrylic compounds, namely isoferulic acid and cinnamic acid, have a specific inhibitory effect on Shp2 and the isoferulic acid and the cinnamic acid can be prepared into the Shp2-specific inhibitors. The invention further verifies that both the isoferulic acid and the cinnamic acid can inhibit EGF-induced phosphorylation of Erk by inhibiting the activity of the Shp2 in the cellular level, the cinnamic acid can also inhibit EGF-induced migration of MDA-MB-468 cells, and the isoferulic acid and the cinnamic acid are expected to be developed into medicines for preventing or treating of Shp2-related diseasesand are of a great significance on the development of the medicines targeting the Shp2.

The invention provides a method for extracting isochlorogenic acid from plant processing by-products, and particularly belongs to the technical field of plant by-product utilization. The method comprises the following steps: dissolving the plant processing by-product by adopting a first short-chain alcohol solvent to obtain a first mixed solution; mixing the first mixed solution with a non-polar organic extraction solvent, and extracting to obtain an alcohol-water phase; precipitating the alcohol-water phase by adopting a precipitation reagent to obtain an isochlorogenic acid precipitate; dissolving the isochlorogenic acid precipitate in a second short-chain alcohol solvent, mixing with acid, carrying out double decomposition reaction, and carrying out solid-liquid separation to obtain a first filtrate; adjusting the pH value to 2-4, removing short-chain alcohol in the first filtrate, and carrying out solid-liquid separation to obtain an isochlorogenic acid precipitate crude product; and dissolving the isochlorogenic acid precipitate crude product in a third short-chain alcohol solvent, and recrystallizing to obtain the isochlorogenic acid. The method provided by the invention can realize comprehensive utilization of plant processing byproducts, and is simple in process, easy to operate and suitable for large-scale industrial production.

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating women's climacteric syndrome, its preparation method and its application in treating climacteric syndrome. The raw material medicine composition of the composition is Cimicifuga: puerariae: red peony: roasted licorice at a ratio of 1:1 to 1.5:1:1. The preparation method of the extract of the composition is a conventional water decoction and alcohol precipitation process, or ethanol immersion, reflux, filtration to remove residue, filtrate to stand still, further filtration to remove residue, recovery of ethanol, drying and crushing to obtain the product. The extract of the composition contains effective active ingredients such as acteoside, isoferulic acid, puerarin, paeoniflorin, glycyrrhizic acid, glycyrrhetinic acid, liquiritin and the like. The extract obtained from the traditional Chinese medicine composition of the present invention has a significant therapeutic effect on the climacteric syndrome model caused by castrated female rats, can significantly increase the uterine wet weight and uterine coefficient of the model rats, and inhibit the abnormal increase in the body temperature of the model rats. High, and have obvious recovery and regulation effects on estrogen levels such as E2, FSH, LH.

The invention provides a medicinal composition for preventing vascular thrombosis diseases. The medicinal composition consists of 4 to 16 parts of ferulic acid, 2.5 to 10 parts of protocatechuic acid,3 to 12 parts of p-coumaric acid, and 2 to 8 parts of isoferulic acid. The antithrombotic titer of the medicinal composition prepared in the invention can reach 96.66 percent. The medicinal composition of the invention comprises no toxic ingredient 5-hydroxymethyl furfural, the potential toxic harm of rhizoma sparganii crude drugs on the inheritance and reproduction of human bodies can be avoided, the medicinal composition is safe to use, and the curative effect is improved; finally, a foundation is set for further developing novel active ingredient composition preparations.

The invention discloses a quality detection method of asiatic toddalia root gargle, comprising the following steps of: (1) identifying the asiatic toddalia root gargle; and (2) measuring the content according to a high-efficiency liquid chromatography: A, performing of a chromatograph condition and system adaptability test; B, comparison product solution preparation: precisely weighting a proper amount of isoferulic acid comparison product and preparing into the solution containing 20 mug per 1ml by using 10% ethanol; C, preparation of a test sample solution; and D, application of a measuringmethod: precisely absorbing 10 mul of the comparison production solution and 10 mul of the test sample solution, injecting in a liquid chromatograph for measuring, wherein every 100ml of the product contains at least 4.0mg of rhizoma cimicifugae metered by isoferulic acid. The invention has high test accuracy, can better control the quality of the medicine and ensure the medication safety, and the medicinal materials can be easily obtained.

The invention discloses a processing method of Chinese Cimicifuga decoction pieces. The invention first adopts an optimized cleaning process to clean the Cimicifuga, then uses river sand under acidic conditions to moisten it, and then steams it under high pressure to promote the coffee content of Cimicifuga raw products. Ferulic acid, ferulic acid, isoferulic acid and other components are produced; then after refining honey and mixing, high temperature and high pressure processing, and then microwave radiation treatment, the active ingredients of phenolic acids can be stabilized and will not be fried due to high temperature and open fire The resulting uneven heating, paste sugar and so on. Moreover, the microwave heating efficiency is high, which can evenly distribute the refined honey on the surface of the decoction pieces and penetrate into the inside of the medicinal materials, which can greatly improve the processing effect. The invention provides a strong scientific basis for establishing a new processing method of Cimicifuga cimicifuga Chinese medicine decoction pieces, and has important application prospects.

The invention relates to a compound combination with an effect of synergistically scavenging radicals. Active trace detection is carried out by adopting a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay; the synergistic effects (combination coefficient, CI) of two groups of antioxidant ingredients are evaluated by adopting a dose-effect analysis method on the basis of a median effect principle; a group of compounds for synergistically scavenging the radicals, namely calycosin and isoferulic acid are screened from astragalus membranaceus and cimicifugae foetidae; methanol solutions of the calycosin and the isoferulic acid are combined according to different dose ratios (3:1, 2:1, 1:1, 1:2, or 1:3), so as to determine the DPPH radical scavenging capacity. Thus, the calycosin and the isoferulic acid display the best synergistic effect under the condition that the dose ratio is 1:1.

The invention belongs to the technical field of cosmetics, and particularly relates to an antiseptic composition for cosmetics and a preparation method for the antiseptic composition. The antiseptic composition comprises the following components in parts by weight: 1-10 parts of fructus pistaciae verae extract, 1-10 parts of phellinus linteus extract, 1-8 parts isoferulic acid, 3-20 parts of polyol and 40-60 parts of deionized water. the antiseptic composition provided by the invention consists of the fructus pistaciae verae extract, the phellinus linteus extract and the isoferulic acid; the antiseptic composition has a significant inhibitory effect on various common contaminating bacteria in the cosmetics, and can broaden the antibacterial spectrum of a single component; the active ingredients are all natural ingredients, so that the antiseptic composition has low skin sensitization, and has a broad range of pH tolerance value (3-9); and the antiseptic composition can be applied to various skin care products, color cosmetics or cosmeceuticals.