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A kind of pharmaceutical composition for preventing and treating vascular embolism disease

A technology of embolization and composition, applied in the field of research and development of traditional Chinese medicine

Active Publication Date: 2020-12-04
亳州市隆泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the use of ferulic acid, protocatechuic acid, p-coumaric acid, and isoferulic acid for compatibility to prevent and treat vascular embolism has not yet been reported.

Method used

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  • A kind of pharmaceutical composition for preventing and treating vascular embolism disease
  • A kind of pharmaceutical composition for preventing and treating vascular embolism disease
  • A kind of pharmaceutical composition for preventing and treating vascular embolism disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Preparation of Antithrombotic Dropping Pills:

[0058] Take 40g of ferulic acid, 25g of protocatechuic acid, 120g of p-coumaric acid, 80g of isoferulic acid, and 500g of polyethylene glycol, heat to melt, mix well, move to the liquid container of the dropping pill machine, and keep warm for 90 ℃, drop into the cooled simethicone, and make 1000g drop pills. Example 2

Embodiment 2

[0059] Preparation of Antithrombotic Injection:

[0060] Take 160g of ferulic acid, 100g of protocatechuic acid, 30g of p-coumaric acid and 20g of isoferulic acid, add 1800ml of water for injection, stir to dissolve, adjust the pH value to 7.0-7.5 with saturated sodium hydroxide solution, add 10g of needle Use activated carbon, add water for injection to 2000ml, mix well, boil for 30 minutes, refrigerate, filter, add water for injection to 5000ml, filter with 0.45μm and 0.22μm microporous membranes respectively, pack separately, each 5ml, fill Nitrogen, seal, and circulate steam for 30 minutes to get 1000 concentrated solution for injection.

Embodiment 3

[0062] Preparation of Antithrombotic Capsules:

[0063] Take 160g of ferulic acid, 25g of protocatechuic acid, 60g of p-coumaric acid, and 80g of isoferulic acid, add appropriate amount of starch, mix well, pack in capsules, and make 1000 capsules.

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Abstract

The invention provides a medicinal composition for preventing vascular thrombosis diseases. The medicinal composition consists of 4 to 16 parts of ferulic acid, 2.5 to 10 parts of protocatechuic acid,3 to 12 parts of p-coumaric acid, and 2 to 8 parts of isoferulic acid. The antithrombotic titer of the medicinal composition prepared in the invention can reach 96.66 percent. The medicinal composition of the invention comprises no toxic ingredient 5-hydroxymethyl furfural, the potential toxic harm of rhizoma sparganii crude drugs on the inheritance and reproduction of human bodies can be avoided, the medicinal composition is safe to use, and the curative effect is improved; finally, a foundation is set for further developing novel active ingredient composition preparations.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for preventing and treating vascular thrombosis diseases. Background technique [0002] The prevention and treatment of vascular embolism disease (thrombus) has been a research hotspot in recent years. Thrombosis is the main cause of arterial diseases such as myocardial infarction and stroke, as well as venous thromboembolic diseases and the death of patients, and traditional Chinese medicine for promoting blood circulation and removing blood stasis plays an important role in the prevention and treatment of thrombosis. [0003] The basis of the efficacy of traditional Chinese medicine comes from the chemical components contained in it. Through the extraction, separation and identification of the existing chemical components of traditional Chinese medicine, many chemical substances with curative effec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P9/00A61P9/10A61P7/02
CPCA61K31/192A61P7/02A61P9/00A61P9/10
Inventor 时海燕徐男
Owner 亳州市隆泰药业有限公司
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