Composition, preparation method and medical application of polyisoflavone derivatives
A technology of derivatives and compositions, applied in the directions of drug combinations, compounds of Group 5/15 elements of the periodic table, chemical instruments and methods, etc., can solve the problems of unsatisfactory hypoglycemic effect, etc., and achieve good hypoglycemic effect. Effect
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Embodiment 1
[0028] Preparation of 4′,7-diacetylisoferulic acid genistein:
[0029] a) Preparation of acetyl isoferulic acid:
[0030] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;
[0031] 2. Place in an ice bath to lower the temperature of the system to 0°C, then add 5 drops of anhydrous pyridine dropwise;
[0032] 3. Heat up to 110°C under stirring, and reflux for 3 hours;
[0033] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;
[0034] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.
[0035] b) Preparation of 4′,7-diacetylisoferulic acid genistein:
[0036] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic ...
Embodiment 2
[0069] Preparation of 4′,7-diacetylisoferulic acid genistein:
[0070] a) Preparation of acetyl isoferulic acid:
[0071] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;
[0072] 2. Place in an ice bath to lower the system temperature to 2.5°C, then add 5 drops of anhydrous pyridine dropwise;
[0073] 3. Heat up to 115°C with stirring, and reflux for 3.5 hours;
[0074] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;
[0075] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.
[0076] b) Preparation of 4',7-diacetylisoferulic acid genistein:
[0077] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic acid...
Embodiment 3
[0099] Preparation of 4′,7-diacetylisoferulic acid genistein:
[0100] a) Preparation of acetyl isoferulic acid:
[0101] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;
[0102] 2. Place in an ice bath to lower the temperature of the system to 5°C, then add 5 drops of anhydrous pyridine dropwise;
[0103] 3. Heat up to 120°C under stirring, and reflux for 4 hours;
[0104] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;
[0105] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.
[0106] b) Preparation of 4′,7-diacetylisoferulic acid genistein:
[0107] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic ...
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