Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition of multiple isoflavone derivatives, preparing method and medical application

A technology of derivatives and compositions, applied in the directions of drug combinations, compounds of Group 5/15 elements of the periodic table, chemical instruments and methods, etc., can solve the problems of unsatisfactory hypoglycemic effect, etc., and achieve good hypoglycemic effect. Effect

Active Publication Date: 2016-12-07
BEIJING UNIV OF CHINESE MEDICINE
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most isoflavone derivatives are administered alone. Although some effects have been obtained, the hypoglycemic effect is not very satisfactory. At present, the following studies on the combination of isoflavone derivatives and their hypoglycemic activity have not been reported after searching

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition of multiple isoflavone derivatives, preparing method and medical application
  • Composition of multiple isoflavone derivatives, preparing method and medical application
  • Composition of multiple isoflavone derivatives, preparing method and medical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of 4′,7-diacetylisoferulic acid genistein:

[0029] a) Preparation of acetyl isoferulic acid:

[0030] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;

[0031] 2. Place in an ice bath to lower the temperature of the system to 0°C, then add 5 drops of anhydrous pyridine dropwise;

[0032] 3. Heat up to 110°C under stirring, and reflux for 3 hours;

[0033] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;

[0034] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.

[0035] b) Preparation of 4′,7-diacetylisoferulic acid genistein:

[0036] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic ...

Embodiment 2

[0069] Preparation of 4′,7-diacetylisoferulic acid genistein:

[0070] a) Preparation of acetyl isoferulic acid:

[0071] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;

[0072] 2. Place in an ice bath to lower the system temperature to 2.5°C, then add 5 drops of anhydrous pyridine dropwise;

[0073] 3. Heat up to 115°C with stirring, and reflux for 3.5 hours;

[0074] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;

[0075] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.

[0076] b) Preparation of 4',7-diacetylisoferulic acid genistein:

[0077] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic acid...

Embodiment 3

[0097] Preparation of 4′,7-diacetylisoferulic acid genistein:

[0098] a) Preparation of acetyl isoferulic acid:

[0099] 1. Add 1g isoferulic acid and 20mL acetyl chloride into a 100mL round bottom flask;

[0100] 2. Place in an ice bath to lower the temperature of the system to 5°C, then add 5 drops of anhydrous pyridine dropwise;

[0101] 3. Heat up to 120°C under stirring, and reflux for 4 hours;

[0102] 4. After cooling at room temperature, a large amount of solids appeared, suction filtered, and the filter residue was washed with water and absolute ethanol in sequence, and dried to obtain the crude product of acetylisoferulic acid;

[0103] 5. The crude product is eluted with 300-400 mesh silica gel, and the elution condition is petroleum ether: ethyl acetate: methanol: acetic acid = 300:100:50:10 to obtain acetyl isoferulic acid monomer.

[0104] b) Preparation of 4′,7-diacetylisoferulic acid genistein:

[0105] 1. Weigh 0.3g of genistein, 0.1g of acetylisoferulic ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a composition of multiple isoflavone derivatives, and further discloses a preparing method of the composition and medical application of the composition in treating diabetes. The composition of the isoflavone derivatives is prepared by carrying out structural modification on 4,7-diacetyl isoferulic acid genistein, 7-2-bromo-ethoxy genistei and a genistein vanadyl complex. Results of administration hypoglycemic activity screening and cell activity experiments show that the composition has a very good hypoglycemic effect which is better that that of single compounds, and can be used for preparing medicine for treating type II diabetes.

Description

technical field [0001] The invention discloses a composition of polyisoflavone derivatives, a preparation method of the composition and its medical application in treating diabetes, and belongs to the technical field of medicine and pharmacy. Background technique [0002] Chickpea is the dried seed of the leguminous plant Chickpea Cicer arietinum L. Chickpea has long been used as Uighur folk medicine and traditional Chinese medicine to treat diabetes, especially in the 2000 National Ministry of Health "Drug Standard "Uyghur medicine sub-volume and "Uyghur medicine annals" have clearly recorded the medicinal efficacy of chickpea in treating diabetes. Modern research has found that chickpea isoflavones have a certain hypoglycemic effect, and genistein, chickpea A, and formononetin are all components of chickpea isoflavones. [0003] At present, most isoflavone derivatives are administered alone. Although some effects have been achieved, the hypoglycemic effect is not very sat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07F9/00A61P3/10A61K31/35
CPCA61K31/35C07D311/36C07F9/00
Inventor 徐暾海李朋收刘铜华解生旭张曼祺
Owner BEIJING UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com