A traditional Chinese medicine composition for treating women's climacteric syndrome and its preparation method
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A combination and syndrome technology, applied in the field of traditional Chinese medicine, can solve the problems of expensive Livmin tablets
Inactive Publication Date: 2021-06-04
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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And imported Livmin tablets are expensive, and the price of 30 tablets / box is nearly 400 yuan
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Embodiment 1
[0017] Example 1 Accurately weigh 1000g Cimicifuga, 1500g Pueraria Radix, 1000g Radix Paeoniae Rubra, and 1000g Radix Glycyrrhizae Radix Glycyrrhizae, wash and add 4.5L of 70% ethanol to soak for 4 hours, reflux extraction for 2 hours, and filter; the filter residue is reused with 4.5L of 70% Extract with ethanol under reflux for 2 hours, filter, combine the filtrates twice, let stand, filter, recover the ethanol from the filtrate to a clear paste with a relative density of 1.10 (80°C), dry under reduced pressure and vacuum, and pulverize to obtain extract A (dry powder). Store in vacuum airtight. Measured by HPLC method (dual wavelength, gradient elution): every gram of extract (dry powder) contains isoferulic acid 3.05mg (RSD 1.9%), puerarin 109.37mg (RSD 2.8%), paeoniflorin 38.61mg (RSD2 .6%).
Embodiment 2
[0018] Example 2 Accurately weigh 500g Cimicifuga, 750g Pueraria Radix, 500g Radix Paeoniae Rubra, and 500g Radix Glycyrrhiza Radix, wash and soak in 2.5L of water for 4 hours, boil for extraction for 2 hours, and filter; the filter residue is reused with 2.5L of water for extraction by boiling For 2 hours, filter, combine the filtrate twice, centrifuge, concentrate to a clear paste with a relative density of 1.16 (80°C), let cool to room temperature, add ethanol to make the alcohol content reach 80%, stir well, let stand, filter, and filtrate The ethanol is recovered and concentrated to a clear paste with a relative density of 1.16 (80° C.), dried and granulated to obtain Extract B (dry powder), which is stored in a vacuum seal. Measured by HPLC method (dual wavelength, gradient elution): every gram of extract (dry powder) contains isoferulic acid 2.09mg (RSD 1.8%), puerarin 89.91mg (RSD 2.9%), paeoniflorin 29.43mg (RSD 2.7%).
Embodiment 3
[0019] Example 3 Accurately weigh 2g of Cimicifuga, 2g of Pueraria Radix, 2g of Radix Paeoniae Rubra, and 2g of Radix Glycyrrhizae, after washing, add 100mL of 70% ethanol to soak for 4 hours, reflux extraction for 2 hours, and filter; the filter residue is reused with 4.5L of 70% ethanol Reflux extraction for 2 hours, filter, combine the two filtrates, recover ethanol to a clear paste with a relative density of 1.12 (80°C), place it to cool to room temperature, seal, and refrigerate at -20°C to obtain Extract C.
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Abstract
The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating women's climacteric syndrome, its preparation method and its application in treating climacteric syndrome. The raw material medicine composition of the composition is Cimicifuga: puerariae: red peony: roasted licorice at a ratio of 1:1 to 1.5:1:1. The preparation method of the extract of the composition is a conventional water decoction and alcohol precipitation process, or ethanol immersion, reflux, filtration to remove residue, filtrate to stand still, further filtration to remove residue, recovery of ethanol, drying and crushing to obtain the product. The extract of the composition contains effective active ingredients such as acteoside, isoferulic acid, puerarin, paeoniflorin, glycyrrhizic acid, glycyrrhetinic acid, liquiritin and the like. The extract obtained from the traditional Chinese medicine composition of the present invention has a significant therapeutic effect on the climacteric syndrome model caused by castrated female rats, can significantly increase the uterine wet weight and uterine coefficient of the model rats, and inhibit the abnormal increase in the body temperature of the model rats. High, and have obvious recovery and regulation effects on estrogen levels such as E2, FSH, LH.
Description
technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating women's climacteric syndrome, its preparation method and its application in treating climacteric syndrome. Background technique [0002] Menopausal syndrome, also known as perimenopausal syndrome, refers to a period of time before and after menopause in women, due to a sharp drop in estrogen levels, resulting in imbalance of the hypothalamus-pituitary-gonadal axis, and the occurrence of autonomic dysfunction or disorder. The main symptoms, about 25% of menopausal women have serious symptoms, because the estrogen level drops suddenly, causing a series of symptoms such as vaginal and / or uterine atrophy and dryness, osteoporosis, dizziness, headache, heat and sweating. This disease belongs to the categories of TCM "diseases before and after menopause", "dryness of the viscera" and "stagnation syndrome". Before and a...
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/65A61P15/12
Inventor 沈明勤石磊王颖钰丁永芳彭蕴如
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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