36 results about "Liquiritoside" patented technology

The invention provides liquiritin gel as well as a preparation method and application thereof. The liquiritin gel is prepared from the following components in concentration: 0.1 weight percent to 2 weight percent of liquiritin, 0.1 weight percent to 4 weight percent of carbomer, 0.1 weight percent to 4 weight percent of water-soluble cellulose ether compounds and 1 to 10 mL / Kg of triethanolamine. Wherein liquiritin and the water-soluble cellulose ether compound are respectively used as a main thickening agent and an auxiliary thickening agent, a synergistic thickening system is more stable and more suitable for liquiritin compared with a single thickening system or other neutralization systems, and the liquiritin and the water-soluble cellulose ether compound can synergistically adjust viscosity; triethanolamine is used as a neutralizer to neutralize carboxyl of carbomer to form gel; carbomer and a water-soluble cellulose ether compound are cooperated according to a specific ratio and can be different from a single thickening system or different neutralization systems, so that the liquiritin gel with excellent film-forming property, proper flowability and high transdermal absorption efficiency is prepared.

The invention provides an application of liquiritin in preparation of a PPAR gamma receptor partial agonist. Through a structure-based high-throughput virtual screening technology, it is found that liquiritin can be used as a partial agonist of a PPAR gamma receptor, and the relative activation efficiency of liquiritin is 35.9% of that of rosiglitazone; in-vitro experiments prove that liquiritin can remarkably promote glucose uptake and consumption of HepG2 cells and does not induce adipocyte differentiation; in-vivo experiments prove that liquiritin can effectively improve the blood glucose level of an insulin resistance mouse model induced by high fat diet and reduce the level of serum proinflammatory factors. Compared with thiazolidinedione compounds, liquiritin not only can relieve and treat insulin resistance or related metabolic diseases, but also does not cause adverse reactions such as weight gain, fat accumulation and myocardial hypertrophy, provides a new candidate compound for developing safe and effective anti-diabetic drugs, and has a wide application prospect.

A use of liquiritin in the preparation of a drug for treating atopic dermatitis. Animal experiments show that liquiritin can remarkably lessen the skin lesion severity of an atopic dermatitis mouse model, reduce the ear thickness and the epidermal thickness, and reduce the infiltration degree of dermal lymphocytes, thereby demonstrating that liquiritin has a significant therapeutic effect on atopic dermatitis, has no toxic and side effects on the liver, the spleen and the kidney, and has good clinical application prospects and enormous social benefits, and expanding a new application field for a conventional leguminous plant liquorice extract, i.e., liquiritin.

The preparation method comprises the following steps: directionally enriching glycyrrhizic acid and liquiritin through a four-step process of temperature-controlled countercurrent extraction, acid precipitation and enrichment, membrane filtration and resin separation, and synchronously removing polysaccharides, pectin and bitter substance glycyrrhetinic acid residues. Compared with a traditional method, the method has the triple advantages that (1) the sweetness enhancing function is achieved, and glycyrrhizic acid and liquiritin cooperate to achieve 2-10 times of wine sweetness adjustment; 2) the stability is prominent, and the turbidity is only increased by 2NTU (25NTU in the traditional process) through 30-day acceleration test; 3) the sensory quality is optimized, and the sensory score of the blended wine body reaches 92 (the medicinal aroma and the wine aroma are harmonious and precipitate-free).

The invention relates to a traditional Chinese medicine composition which comprises more than 1.09 permillage of ephedrine hydrochloride, more than 0.86 permillage of pseudoephedrine hydrochloride, more than 0.17 permillage of peiminine, more than 0.03 permillage of peimine, more than 0.17 permillage of chrysin-7-O-glucuronide, more than 0.002 permillage of glycyrrhetinic acid, more than 11.87 permillage of amygdalin and more than 0.01 permillage of neotuberostemonine. The oral liquid is prepared from more than 2.16 per mill of glycyrrhizic acid, more than 1.97 per mill of oroxylin A, more than 1.97 per mill of oroxylin B, more than 1.23 per mill of liquiritin, more than 0.59 per mill of apiose liquiritin, more than 0.55 per mill of baicalin, more than 0.23 per mill of chlorogenic acid, more than 0.18 per mill of praeruptorin A, more than 0.15 per mill of wild melanosin, more than 0.14 per mill of methyephedrine hydrochloride, more than 0.13 per mill of isoliquiritin, more than 0.13 per mill of neochlorogenic acid and more than 0.13 per mill of cryptochlorogenic acid. The composition is prepared from more than 0.10% of peimine, more than 0.08% of baicalein, more than 0.05% of praeruptorin B, more than 0.04% of praeruptorin C, more than 0.011% of xanthoxylin and more than 0.0006% of formononetin.

The present invention discloses a method for constructing a fingerprint of Gualou Niu Bang decoction, relating to the technical field of analytical chemistry. The method is simple and has high precision, stability, and repeatability. Determination revealed that seven components, including geniposide, liquiritin, hesperidin, arctiin, baicalin, melaleucalyptol A-7-O-β-D-glucuronide, and wogonin, can be used as common characteristic peaks in the fingerprint of Gualou Niu Bang decoction for identification research.

The invention discloses an application of a composition of isoliquiritigenin (glycoside), licochalcone and ethnic groups thereof in personal care products, and relates to the technical field of daily chemicals, and the composition is an anti-allergy soothing composition prepared based on a natural plant licorice extract isoliquiritigenin or a glycoside compound isoliquiritigenin thereof, licochalcone A and ethnic groups of licochalcone B, C, D, E and G. The traditional Chinese medicine composition has multiple functions of resisting allergy, relieving, resisting bacteria, diminishing inflammation, improving skin itch and stabbing pain and the like, does not contain hormones and antibiotics, has no toxic or side effect, is mild in effect and non-irritant to skin, can be used for treating skin allergy, red and swollen skin, itch and stabbing pain caused by various reasons, is applied to cosmetics and skin care products, such as gel, cream, masks and facial cleansers, and can be used for treating skin allergy, red and swollen skin, pruritus and stabbing pain caused by various reasons. The skin care product is mild to human bodies, safe and non-irritant, is suitable for sensitive skin, is suitable for people of all ages to use, has strong market competitiveness, and has relatively high economic and social benefits and the like.

The invention provides a planting method for increasing the content of effective components of liquorice, and belongs to the technical field of Chinese herbal medicine planting. The planting method comprises the steps that 1.6-2.4 kg of mineral source humic acid fertilizer is applied per mu from June to August, and 1.6-2.4 kg of microelement water-soluble fertilizer is applied per mu after 7-10 days; the trace element water-soluble fertilizer contains more than or equal to 5% of zinc, manganese, calcium, magnesium, iron and molybdenum. The soil microenvironment is improved through humic acid, root development and secondary metabolism precursor accumulation are promoted, photosynthesis and secondary metabolism pathways are accurately activated in combination with microelements, the content of glycyrrhizic acid and liquiritin is synergistically increased, effective components of the licorice medicinal material meet the requirements of Chinese Pharmacopoeia, and ecological management and medicinal material efficient production value are achieved.

The invention provides a cough-relieving and phlegm-eliminating composition and a preparation method thereof. The cough-relieving and phlegm-eliminating composition is prepared from the following raw materials: anhydrous morphine, anhydrous codeine phosphate, apigenin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, trans-anethole, camphor and sodium benzoate. The composition further comprises a luffa stem extract, an atractylodes lancea rhizome extract and a radix ranunculi ternati bark extract. The cough-relieving and phlegm-eliminating composition provided by the invention has the advantages of few impurities, clear and remarkable drug effect and small side effect. Under the action of the core antitussive drug, three plant extracts of luffa stem, Atractylodes lancea and Ranunculus ternatus Thunb. Are creatively added, so that the phlegm eliminating capacity and the overall antitussive effect of the whole formula are remarkably enhanced. The cough-relieving and phlegm-eliminating composition disclosed by the invention realizes the synergistic interaction of '1 + 1 + 1gt, 3' on the core indexes of inhibiting the cough frequency, prolonging the cough latency period, promoting sputum excretion and the like, and realizes the cough-relieving and phlegm-eliminating effects of treating both symptoms and root causes through the multi-target-point and multi-mechanism synergistic effect.

The invention belongs to the field of analysis of traditional Chinese medicine preparations, and particularly discloses a method for determining the content of 15 components in a Xiaoyao preparation through quantitative analysis of multi-components by single marker and application of the method. According to the invention, pentagalloylglucose is used as an internal reference substance for quantitative analysis of multi-components by single marker; relative correction factors between the pentagalloylglucose and gallic acid, chlorogenic acid, albiflorin, paeoniflorin, schaftoside, ferulic acid, apiose liquiritin, liquiritin, senkyunolide I, paeoniflorin, senkyunolide H, formononin, liquiritigenin and glycyrrhizic acid in the Xiaoyao preparation are established, and the contents of the 15 components in the Xiaoyao preparation are calculated through the correction factors. The method disclosed by the invention is high in practicability, simple to operate, cost-saving and accurate and reliable in detection result, overcomes the defects of the quality detection method of the Xiaoyao preparation, especially the Xiaoyao mixture, and provides a new way for quality control of the Xiaoyao preparation and internal quality evaluation of medicines.

An object of the present invention is to mask an unpleasant taste or odor of an oral composition, particularly an unpleasant taste or odor derived from beans, and further to provide a method for masking an oral composition having an unpleasant taste or odor, an oral composition in which an unpleasant taste or odor is masked, and a method for producing the same. [Solution] Isoliquiritigenin glycosides, more specifically, isoliquiritin, neoisoliquiritin, isoliquiritin apioside, and liclaside, can mask unpleasant tastes or odors, so the above problem can be solved by preparing a composition containing one or more of these isoliquiritigenin glycosides as active ingredients and using this as a masking composition.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The invention relates to construction of a Qingbai Tongbi capsule fingerprint spectrum and application of the Qingbai Tongbi capsule fingerprint spectrum in drug quality control. The HPLC fingerprint spectrum of the Qingbai Tongbi capsule has 24 characteristic fingerprint chromatographic peaks, wherein the peak 4 is catechin, the peak 10 is sinomenine, the peak 12 is gallic acid, the peak 13 is magnoflorine, the peak 14 is paeoniflorin, the peak 17 is liquiritin, the peak 18 is 1, 2, 3, 4, 6-O-pentagalloylglucose, and the peak 24 is ammonium glycyrrhizinate.

The present application relates to the technical field of traditional Chinese medicine extraction and separation, and particularly relates to a method for extracting glycyrrhizin from glycyrrhizin crude product and an extract containing glycyrrhizin prepared by the method. The method comprises the following steps: mixing solvents, adjusting pH value, controlling difference in solvent polarity of an extraction system, controlling extraction temperature, layering, vacuum concentration and spray drying to obtain glycyrrhizin finished product. The present application realizes efficient extraction and enrichment of glycyrrhizin by using purified water, ethyl acetate and n-heptane to form a composite extraction system based on the difference in solvent polarity.

The invention discloses application of a composition of liquiritigenin (liquiritin) and glycyrrhizic acid and salts thereof in personal care products, and relates to the technical field of daily chemicals. Liquiritigenin or liquiritin and glycyrrhizic acid and salts thereof are compounded according to a preset proportion, and the components are taken from licorice natural plants; active ingredients of the composition have multiple functions of resisting bacteria, diminishing inflammation, balancing sebum secretion, removing redness and resisting allergy and the like, then the prepared composition is added into personal care products such as masks, essence, skin care cream, face cream and sunscreens according to the proportion of 0.005%-10% (w / w), synergistic interaction is achieved, the obtained composition is remarkable in relieving and anti-allergy effect, the preparation method is simple and convenient, safety is high, and the composition is suitable for industrial production. Wide market application prospects are realized.

The present invention proposes a traditional Chinese medicine composition, comprising an active ingredient prepared from goat horn or antelope horn, scutellaria baicalensis, fritillaria cirrhosa, liquorice, rhubarb, gypsum, bezoar and green stone, wherein the active ingredients include, by mass, more than 1600 parts of amino acids, more than 120 parts of gallic acid, more than 130 parts of liquiritin, more than 20 parts of liquiritigenin, more than 400 parts of baicalin, more than 40 parts of melaleucoside, more than 120 parts of wogonin, more than 280 parts of glycyrrhizic acid, more than 12 parts of chrysin-7-O-β-D-glucuronic acid, more than 50 parts of aloe-emodin-8-O-β-D-glucoside, more than 30 parts of chrysophanol-1-O-β-D-glucoside, more than 45 parts of chrysophanol-8-O-β-D-glucoside, more than 260 parts of hyodeoxycholic acid and more than 150 parts of cholic acid. The composition of the present invention has antipyretic, anti-inflammatory and antitussive effects.

The invention relates to the technical field of liquorice secondary metabolite accumulation and medicinal material quality improvement, in particular to a method for promoting efficient accumulation of triterpenoids (including glycyrrhizic acid) and flavonoids (including liquiritin) in a liquorice inflate root system through UV-B radiation. According to the invention, key genes (PAL1, CHS, CYP88D6 and CYP72A154) in phenylpropane metabolism and terpenoid synthesis pathways are activated through UV-B radiation treatment with specific intensity (107 [mu] W / cm < 2 >) and different durations (7d and 15d), so that the content of glycyrrhizic acid, liquiritin and other substances is remarkably increased. The content difference of glycyrrhizic acid, liquiritin and other substances in the glycyrrhiza inflate cultivated species (G) and the glycyrrhiza inflate wild species (W) is obvious. The invention provides an efficient and environment-friendly technical scheme for quality improvement and sustainable production of liquorice.

The invention discloses a composition for increasing the selenium content in liquiritin, glycyrrhiza polysaccharide and liquorice and application of the composition. The technical problem to be solved by the invention is how to increase the content of selenium and active substances in liquorice. To this end, the present invention provides a composition containing a rhizobium and a selenite, the rhizobium being a mesorhizium temperulum 01578 (i.e., a mesorhizium temperulum CCBAU 01578), and a method for producing the same, and the present invention provides a composition containing the rhizobium, i.e., a mesorhizium temperulum CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU CCBAU. Experiments prove that when the rhizobium and exogenous selenium are jointly applied, the content of liquiritin, glycyrrhiza polysaccharide, selenium, fat, protein, flavone, saponin and / or glycyrrhizic acid in liquorice can be effectively increased, and a reference basis is provided for increasing the medicinal value of liquorice and the like.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition with a qi-blood tonifying effect and a pharmaceutical preparation and application thereof. The composition is prepared from the following raw materials in parts by weight: 0.2 to 1 part of tangeretin, 0.2 to 5 parts of nobiletin, 0.05 to 0.2 part of lobetyolin, 0.1 to 1 part of allantoin, 0.1 to 1 part of liquiritigenin, 0.1 to 1 part of alnus ketone, 0.02 to 0.2 part of rutin, 0.2 to 2 parts of apiose liquiritin and 0.1 to 1 part of ammonium glycyrrhizinate. The traditional Chinese medicine composition has the remarkable effects of replenishing blood and qi, treating anemia and resisting fatigue.

The present invention discloses a method for determining the contents of six components in Qingwei Bao'an Pills by the method of multi-component quantification by single marker, belonging to the technical field of traditional Chinese medicine detection. The method for determining the contents of six components in Qingwei Bao'an Pills by the method of multi-component quantification by single marker provided by the present invention uses neohesperidin as an internal reference substance. According to the relative correction factors obtained between neohesperidin and liquiritin, narirutin, naringin, hesperidin, and ammonium glycyrrhizinate, the contents of six main pharmacologically active components in Qingwei Bao'an Pills can be quickly detected, the detection efficiency can be improved, a basis is provided for the quality control standard of Qingwei Bao'an Pills products, and it is convenient for the production and detection of Qingwei Bao'an Pills.

The present application relates to the technical field of traditional Chinese medicine quality detection, and specifically discloses a detection method for Angelica drink composition, which comprises the following steps: (1) preparing a test sample solution; (2) preparing a mixed reference sample solution and / or a paeonol reference sample solution; (3) determining the test sample solution and the paeonol reference sample solution and / or the mixed reference sample solution to obtain the content of paeonol; (4) taking paeonol as an internal standard substance, and calculating the contents of caffeic acid, ferulic acid, glycyrrhizin, calycosin-7-glucoside, epimedoside, senkyunol I, rosmarinic acid, 5-O-methylvisamminol glycoside and glycyrrhizic acid by using an internal standard method; the chromatographic column of a liquid chromatograph is made of octadecylsilane bonded silica gel as a stationary phase, methanol as a mobile phase A, and a 0.06-0.2 vol% phosphoric acid aqueous solution as a mobile phase B for gradient elution. The detection method is practical, simple to operate, fast in testing, accurate and low in cost.

The disclosure relates to a traditional Chinese medicine composition, comprising active ingredients derived from Cornu caprae or Cornu saigae tataricae, Radix scutellariae, Bulbus fritillariae ussuriensis, Radix glycyrrhizae, Radix et rhizoma rhei, Gypsum fibrosum, Calculus bovis artifactus and Lapis Chloriti, the said active ingredients comprise in parts by weight: at least 1600 parts of amino acids; at least 120 parts of gallic acid; at least 130 parts of liquiritin; at least 20 parts of liquiritigenin; at least 400 parts of baicalin; at least 40 parts of oroxyloside; at least 120 parts of wogonoside; at least 280 parts of glycyrrhizic acid; at least 12 parts of chrysin-7-O-β-D-glucoronic acid; at least 50 parts of aloe-emodin-8-O-β-D-glucopyranoside; at least 30 parts of chrysophanol-1-O-β-D-glucopyranoside; at least 45 parts of chrysophanol-8-O-β-D-glucopyranoside; at least 260 parts of hyodeoxycholic acid; at least 150 parts of cholic acid. The traditional Chinese medicine composition in the present invention possess antipyretic, anti-inflammatory and antitussive effects.

The invention discloses an application of neoliquiritin in preparation of a medicine for treating myocardial hypertrophy. The invention discovers that the neoliquiritin has a remarkable myocardial hypertrophy resisting effect and has a prospect of being developed into the myocardial hypertrophy resisting medicine. Technicians in the field know that isoliquiritin is an isomeride of neoliquiritin, mother nucleus structures are flavanone skeletons, but the myocardial hypertrophy resistance effect of isoliquiritin is very weak and is far better than that of neoliquiritin, and the technical effect is unexpected by the technicians in the field.

The invention discloses Qinggongning granules and a quality detection method thereof, and relates to the technical field of medicine detection. The Qinggongning granules are prepared from 11 medicines such as angelica sinensis, ligusticum wallichii and scalded peach kernels, and a quality detection method of the Qinggongning granules comprises the following steps: performing quantitative analysis of multi-components by single marker by taking aesculetin as an internal standard substance, establishing relative correction factors of liquiritin, calycosin-7-glucoside, amygdalin and leonurine hydrochloride, and calculating the content of each component in the Qinggongning granules through the relative correction factors. The Qinggongning granule quality detection method provided by the invention has the advantages of high practicability, simplicity in operation, low detection cost and accurate and reliable detection result, overcomes the singleness of Qinggongning granule quality control, provides a new way for Qinggongning granule quality evaluation, and has wide application prospects. The method has important significance in enhancing the overall quality control of Qinggongning granules and ensuring the clinical curative effect of the Qinggongning granules.

The present invention relates to a composition of paeoniflorin and isoliquiritigenin and application thereof. The composition according to the present invention is rich in raw materials, and has the effects of anti-inflammation, antioxidant, inhibiting collagen deposition, etc., and can be effectively used to treat diffuse interstitial pulmonary fibrosis with high economic and social benefits.

The invention relates to the technical field of medicines, in particular to an anti-ulcerative colitis pharmaceutical composition containing liquiritin and atractylenolide I. The pharmaceutical composition comprises active components or pharmaceutically acceptable salts, tautomers, stereoisomers and pharmaceutic adjuvants of the active components, and the active components comprise liquiritin and atractylenolide I. The invention further provides a preparation method of the anti-ulcerative colitis pharmaceutical composition containing liquiritin and atractylenolide I. Compared with the prior art, the invention firstly discloses that the combination of liquiritin and atractylenolide I has obvious curative effects on improving intestinal tissue lesion of ulcerative colitis disease, reducing sexual cell infiltration of colitis and improving colon and cecum states of UC mice, has no toxic or side effect, is not easy to generate tolerance, and has no toxic or side effect. The discovery has great influence on the research and treatment of ulcerative colitis diseases, and has clinical practical value.

The invention discloses a method for simultaneously determining nine index components in a Zhibeng bacteriostatic liquid and constructing a characteristic chromatogram and application, and belongs to the technical field of detection and analysis. Octadecylsilane chemically bonded silica is used as a filling agent; 0.1% phosphoric acid water is used as a mobile phase A, and acetonitrile is used as a mobile phase B; the detection wavelength 316 nm is used for establishing a characteristic spectrum and determining the content of cimicifugin and liquiritin, the detection wavelength 402 nm is used for determining the content of hydroxysafflor pigment A and dehydrated safflower yellow B, the detection wavelength 254 nm is used for determining the content of ganoderic acid A and schizandrin, and the detection wavelength 275 nm is used for determining the content of lozastilbin, salidroside and 5-hydroxymethylfurfural. According to the method, separation and accurate detection are realized by adopting a gradient elution procedure. So far, no report about simultaneous determination of the nine components is found, and the method makes up the blank of quality control and fingerprint spectrum research in prescriptions containing the medicinal materials.

The application discloses a kind of HPLC fingerprint detection methods of traditional Chinese medicine, the traditional Chinese medicine is made of ten traditional Chinese medicinal materials such as radix codonopsis, atractylodes, poria, licorice, angelica, chuanxiong, white peony root, prepared rehmannia, astragalus, cassia, with the effect of tonifying qi and blood, the fingerprint established in the application includes 11 common characteristic peaks, respectively belong to ten medicinal materials, so it can identify all ten medicinal materials in traditional Chinese medicine, and also identifies 5 components therein, which are glycyrrhizin, ammonium glycyrrhizinate, verbascoside, calycosin-7-glucoside and astragaloside A respectively, so the application can more comprehensively control drug quality, solve the phenomenon of fake and inferior drugs, and ensure the safety and effectiveness of clinical use.

To develop materials that effectively produce anti-inflammatory effects. [Solution] A composition containing glycyrrhizic acid, liquiritin, and isoliquiritin, The mass ratio of glycyrrhizic acid to liquiritin (glycyrrhizic acid:liquiritin) is 1:0.3 to 2. The mass ratio of glycyrrhizic acid to isoliquiritin (glycyrrhizic acid:isoliquiritin) is 1:0.5 to 3. composition.

The invention discloses a processing method of fried licorice root decoction pieces, which comprises the following steps: taking a licorice root medicinal material, removing impurities, cleaning, thoroughly moistening, cutting into thick pieces, frying, controlling the material temperature at 80-120 DEG C and the frying time at 10-25 minutes in the frying process, frying until the sections of the decoction pieces are yellowish, taking out, spreading for cooling, and sieving to remove medicine scraps, thereby obtaining the fried licorice root decoction pieces. The drying step is omitted, the energy consumption and the production cost are reduced, and the working efficiency of decoction piece preparation is improved; by controlling the material temperature and the stir-frying time and combining the color judgment at the stir-frying end point, the quantity value transmission result of the key quality attribute'content '(liquiritin) (glycyrrhizic acid) of the obtained stir-fried licorice root decoction pieces is good, and the method disclosed by the invention is suitable for industrial mass production.