20 results about "Liquiritoside" patented technology

The invention provides liquiritin gel as well as a preparation method and application thereof. The liquiritin gel is prepared from the following components in concentration: 0.1 weight percent to 2 weight percent of liquiritin, 0.1 weight percent to 4 weight percent of carbomer, 0.1 weight percent to 4 weight percent of water-soluble cellulose ether compounds and 1 to 10 mL / Kg of triethanolamine. Wherein liquiritin and the water-soluble cellulose ether compound are respectively used as a main thickening agent and an auxiliary thickening agent, a synergistic thickening system is more stable and more suitable for liquiritin compared with a single thickening system or other neutralization systems, and the liquiritin and the water-soluble cellulose ether compound can synergistically adjust viscosity; triethanolamine is used as a neutralizer to neutralize carboxyl of carbomer to form gel; carbomer and a water-soluble cellulose ether compound are cooperated according to a specific ratio and can be different from a single thickening system or different neutralization systems, so that the liquiritin gel with excellent film-forming property, proper flowability and high transdermal absorption efficiency is prepared.

The invention provides an application of liquiritin in preparation of a PPAR gamma receptor partial agonist. Through a structure-based high-throughput virtual screening technology, it is found that liquiritin can be used as a partial agonist of a PPAR gamma receptor, and the relative activation efficiency of liquiritin is 35.9% of that of rosiglitazone; in-vitro experiments prove that liquiritin can remarkably promote glucose uptake and consumption of HepG2 cells and does not induce adipocyte differentiation; in-vivo experiments prove that liquiritin can effectively improve the blood glucose level of an insulin resistance mouse model induced by high fat diet and reduce the level of serum proinflammatory factors. Compared with thiazolidinedione compounds, liquiritin not only can relieve and treat insulin resistance or related metabolic diseases, but also does not cause adverse reactions such as weight gain, fat accumulation and myocardial hypertrophy, provides a new candidate compound for developing safe and effective anti-diabetic drugs, and has a wide application prospect.

The preparation method comprises the following steps: directionally enriching glycyrrhizic acid and liquiritin through a four-step process of temperature-controlled countercurrent extraction, acid precipitation and enrichment, membrane filtration and resin separation, and synchronously removing polysaccharides, pectin and bitter substance glycyrrhetinic acid residues. Compared with a traditional method, the method has the triple advantages that (1) the sweetness enhancing function is achieved, and glycyrrhizic acid and liquiritin cooperate to achieve 2-10 times of wine sweetness adjustment; 2) the stability is prominent, and the turbidity is only increased by 2NTU (25NTU in the traditional process) through 30-day acceleration test; 3) the sensory quality is optimized, and the sensory score of the blended wine body reaches 92 (the medicinal aroma and the wine aroma are harmonious and precipitate-free).

The invention relates to a traditional Chinese medicine composition which comprises more than 1.09 permillage of ephedrine hydrochloride, more than 0.86 permillage of pseudoephedrine hydrochloride, more than 0.17 permillage of peiminine, more than 0.03 permillage of peimine, more than 0.17 permillage of chrysin-7-O-glucuronide, more than 0.002 permillage of glycyrrhetinic acid, more than 11.87 permillage of amygdalin and more than 0.01 permillage of neotuberostemonine. The oral liquid is prepared from more than 2.16 per mill of glycyrrhizic acid, more than 1.97 per mill of oroxylin A, more than 1.97 per mill of oroxylin B, more than 1.23 per mill of liquiritin, more than 0.59 per mill of apiose liquiritin, more than 0.55 per mill of baicalin, more than 0.23 per mill of chlorogenic acid, more than 0.18 per mill of praeruptorin A, more than 0.15 per mill of wild melanosin, more than 0.14 per mill of methyephedrine hydrochloride, more than 0.13 per mill of isoliquiritin, more than 0.13 per mill of neochlorogenic acid and more than 0.13 per mill of cryptochlorogenic acid. The composition is prepared from more than 0.10% of peimine, more than 0.08% of baicalein, more than 0.05% of praeruptorin B, more than 0.04% of praeruptorin C, more than 0.011% of xanthoxylin and more than 0.0006% of formononetin.

The invention provides a cough-relieving and phlegm-eliminating composition and a preparation method thereof. The cough-relieving and phlegm-eliminating composition is prepared from the following raw materials: anhydrous morphine, anhydrous codeine phosphate, apigenin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, trans-anethole, camphor and sodium benzoate. The composition further comprises a luffa stem extract, an atractylodes lancea rhizome extract and a radix ranunculi ternati bark extract. The cough-relieving and phlegm-eliminating composition provided by the invention has the advantages of few impurities, clear and remarkable drug effect and small side effect. Under the action of the core antitussive drug, three plant extracts of luffa stem, Atractylodes lancea and Ranunculus ternatus Thunb. Are creatively added, so that the phlegm eliminating capacity and the overall antitussive effect of the whole formula are remarkably enhanced. The cough-relieving and phlegm-eliminating composition disclosed by the invention realizes the synergistic interaction of '1 + 1 + 1gt, 3' on the core indexes of inhibiting the cough frequency, prolonging the cough latency period, promoting sputum excretion and the like, and realizes the cough-relieving and phlegm-eliminating effects of treating both symptoms and root causes through the multi-target-point and multi-mechanism synergistic effect.

The invention belongs to the field of analysis of traditional Chinese medicine preparations, and particularly discloses a method for determining the content of 15 components in a Xiaoyao preparation through quantitative analysis of multi-components by single marker and application of the method. According to the invention, pentagalloylglucose is used as an internal reference substance for quantitative analysis of multi-components by single marker; relative correction factors between the pentagalloylglucose and gallic acid, chlorogenic acid, albiflorin, paeoniflorin, schaftoside, ferulic acid, apiose liquiritin, liquiritin, senkyunolide I, paeoniflorin, senkyunolide H, formononin, liquiritigenin and glycyrrhizic acid in the Xiaoyao preparation are established, and the contents of the 15 components in the Xiaoyao preparation are calculated through the correction factors. The method disclosed by the invention is high in practicability, simple to operate, cost-saving and accurate and reliable in detection result, overcomes the defects of the quality detection method of the Xiaoyao preparation, especially the Xiaoyao mixture, and provides a new way for quality control of the Xiaoyao preparation and internal quality evaluation of medicines.

The invention provides a method for detecting the contents of multiple index components of a coughing oral liquid, which comprises the following steps of: determining the contents of nine key pharmacodynamic index components, namely ephedrine hydrochloride, pseudoephedrine hydrochloride, apiose liquiritin, isoliquiritin, baicalin, huperzin A glycoside, wogonin, baicalein and wogonin; the detection method has the advantages of simplicity and convenience in operation, high stability, high pertinence and high practicability, can be used as a detection and evaluation method for production and internal quality components of the coughing oral liquid, and has a good market application prospect.

The present application relates to the technical field of traditional Chinese medicine extraction and separation, and particularly relates to a method for extracting glycyrrhizin from glycyrrhizin crude product and an extract containing glycyrrhizin prepared by the method. The method comprises the following steps: mixing solvents, adjusting pH value, controlling difference in solvent polarity of an extraction system, controlling extraction temperature, layering, vacuum concentration and spray drying to obtain glycyrrhizin finished product. The present application realizes efficient extraction and enrichment of glycyrrhizin by using purified water, ethyl acetate and n-heptane to form a composite extraction system based on the difference in solvent polarity.

The invention discloses application of a composition of liquiritigenin (liquiritin) and glycyrrhizic acid and salts thereof in personal care products, and relates to the technical field of daily chemicals. Liquiritigenin or liquiritin and glycyrrhizic acid and salts thereof are compounded according to a preset proportion, and the components are taken from licorice natural plants; active ingredients of the composition have multiple functions of resisting bacteria, diminishing inflammation, balancing sebum secretion, removing redness and resisting allergy and the like, then the prepared composition is added into personal care products such as masks, essence, skin care cream, face cream and sunscreens according to the proportion of 0.005%-10% (w / w), synergistic interaction is achieved, the obtained composition is remarkable in relieving and anti-allergy effect, the preparation method is simple and convenient, safety is high, and the composition is suitable for industrial production. Wide market application prospects are realized.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition with a qi-blood tonifying effect and a pharmaceutical preparation and application thereof. The composition is prepared from the following raw materials in parts by weight: 0.2 to 1 part of tangeretin, 0.2 to 5 parts of nobiletin, 0.05 to 0.2 part of lobetyolin, 0.1 to 1 part of allantoin, 0.1 to 1 part of liquiritigenin, 0.1 to 1 part of alnus ketone, 0.02 to 0.2 part of rutin, 0.2 to 2 parts of apiose liquiritin and 0.1 to 1 part of ammonium glycyrrhizinate. The traditional Chinese medicine composition has the remarkable effects of replenishing blood and qi, treating anemia and resisting fatigue.

The present invention relates to a composition of paeoniflorin and isoliquiritigenin and application thereof. The composition according to the present invention is rich in raw materials, and has the effects of anti-inflammation, antioxidant, inhibiting collagen deposition, etc., and can be effectively used to treat diffuse interstitial pulmonary fibrosis with high economic and social benefits.

The invention discloses a method for simultaneously determining nine index components in a Zhibeng bacteriostatic liquid and constructing a characteristic chromatogram and application, and belongs to the technical field of detection and analysis. Octadecylsilane chemically bonded silica is used as a filling agent; 0.1% phosphoric acid water is used as a mobile phase A, and acetonitrile is used as a mobile phase B; the detection wavelength 316 nm is used for establishing a characteristic spectrum and determining the content of cimicifugin and liquiritin, the detection wavelength 402 nm is used for determining the content of hydroxysafflor pigment A and dehydrated safflower yellow B, the detection wavelength 254 nm is used for determining the content of ganoderic acid A and schizandrin, and the detection wavelength 275 nm is used for determining the content of lozastilbin, salidroside and 5-hydroxymethylfurfural. According to the method, separation and accurate detection are realized by adopting a gradient elution procedure. So far, no report about simultaneous determination of the nine components is found, and the method makes up the blank of quality control and fingerprint spectrum research in prescriptions containing the medicinal materials.

The application discloses a kind of HPLC fingerprint detection methods of traditional Chinese medicine, the traditional Chinese medicine is made of ten traditional Chinese medicinal materials such as radix codonopsis, atractylodes, poria, licorice, angelica, chuanxiong, white peony root, prepared rehmannia, astragalus, cassia, with the effect of tonifying qi and blood, the fingerprint established in the application includes 11 common characteristic peaks, respectively belong to ten medicinal materials, so it can identify all ten medicinal materials in traditional Chinese medicine, and also identifies 5 components therein, which are glycyrrhizin, ammonium glycyrrhizinate, verbascoside, calycosin-7-glucoside and astragaloside A respectively, so the application can more comprehensively control drug quality, solve the phenomenon of fake and inferior drugs, and ensure the safety and effectiveness of clinical use.

To develop materials that effectively produce anti-inflammatory effects. [Solution] A composition containing glycyrrhizic acid, liquiritin, and isoliquiritin, The mass ratio of glycyrrhizic acid to liquiritin (glycyrrhizic acid:liquiritin) is 1:0.3 to 2. The mass ratio of glycyrrhizic acid to isoliquiritin (glycyrrhizic acid:isoliquiritin) is 1:0.5 to 3. composition.

The invention discloses a processing method of fried licorice root decoction pieces, which comprises the following steps: taking a licorice root medicinal material, removing impurities, cleaning, thoroughly moistening, cutting into thick pieces, frying, controlling the material temperature at 80-120 DEG C and the frying time at 10-25 minutes in the frying process, frying until the sections of the decoction pieces are yellowish, taking out, spreading for cooling, and sieving to remove medicine scraps, thereby obtaining the fried licorice root decoction pieces. The drying step is omitted, the energy consumption and the production cost are reduced, and the working efficiency of decoction piece preparation is improved; by controlling the material temperature and the stir-frying time and combining the color judgment at the stir-frying end point, the quantity value transmission result of the key quality attribute'content '(liquiritin) (glycyrrhizic acid) of the obtained stir-fried licorice root decoction pieces is good, and the method disclosed by the invention is suitable for industrial mass production.

Provided is a licorice extract which can be used as a multifunctional raw material. The licorice extract includes: (A) one or more selected from the group consisting of glycyrrhizic acid, a glycyrrhizic acid derivative, glycyrrhetinic acid, and a glycyrrhetinic acid derivative; (B) licorice saponins other than the (A); and (C) licorice flavonoids, and the (B) includes at least 1.7% by mass or more of a licorice saponin H2, 0.2% by mass or more of a licorice saponin G2, and 0.2% by mass or more of macedonoside A, and the (C) includes at least 0.1% by mass or more of liquiritin apioside, 0.1% by mass or more of isoliquiritin apioside, and 0.1% by mass or more of isoliquiritin.

The invention discloses application of nano-zinc oxide in improving biomass and active ingredient content of liquorice, relates to the technical field of plant cultivation, and aims to improve biomass and active ingredient content of liquorice. By applying nano zinc oxide externally, the plant height, root length and dry matter accumulation amount of the liquorice can be remarkably increased, and the biomass of the liquorice is increased; meanwhile, synthesis and accumulation of main active ingredients such as glycyrrhizic acid and liquiritin are effectively promoted; meanwhile, the physiological status of liquorice under stress conditions such as salt stress can be improved, the stress resistance is enhanced, and the in-vivo ion balance and the redox steady state are regulated, so that the growth and quality of liquorice are synergistically improved.

This provides a novel technology related to licorice-derived extracts. [Solution] The food additive composition contains an extract from a plant of the genus Licorice, and the liquiritin content of the composition is 0.3 times or more compared to the glycyrrhizic acid content, and the glycyrrhizic acid content of the composition is 5 mg / g or more.

Extract with a calming and sleep-promoting effect, characterized in that the raw materials for the production of the extract comprise licorice root, wheat and jujube; the glycyrrhizic acid content in the licorice root is ≥ 2.5%, the liquiritin content is ≥ 0.8%, the uridine content in the wheat is ≥ 0.03%, the adenosine content is ≥ 0.02%, the tryptophan content is ≥ 0.1%, the cAMP content in the jujube is ≥ 0.03% and the GABA content is ≥ 0.08%.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition for clearing away heat and toxic materials and protecting liver and improving eyesight and a pharmaceutical preparation and application thereof. The composition is prepared from, by weight, 10-30 parts of ursodesoxycholic acid, 1-5 parts of chenodeoxycholic acid, 5-15 parts of lycium barbarum polysaccharide, 5-18 parts of betaine, 1-5 parts of glycyrrhizic acid, 0.2-5 parts of glycyrrhetinic acid and 1-5 parts of liquiritin, all the components are combined, the composition has the effects of clearing away heat and toxic materials, protecting the liver and improving eyesight, and pharmacological experiments prove that the composition is free of toxic and side effects and free of toxic and side effects. The traditional Chinese medicine composition has obvious effects of clearing heat, preventing and treating asthenopia and improving acute liver injury.