Application of composition of liquiritigenin (glycoside), glycyrrhizic acid and salts thereof in personal care products

Abstract

The invention discloses application of a composition of liquiritigenin (liquiritin) and glycyrrhizic acid and salts thereof in personal care products, and relates to the technical field of daily chemicals. Liquiritigenin or liquiritin and glycyrrhizic acid and salts thereof are compounded according to a preset proportion, and the components are taken from licorice natural plants; active ingredients of the composition have multiple functions of resisting bacteria, diminishing inflammation, balancing sebum secretion, removing redness and resisting allergy and the like, then the prepared composition is added into personal care products such as masks, essence, skin care cream, face cream and sunscreens according to the proportion of 0.005%-10% (w / w), synergistic interaction is achieved, the obtained composition is remarkable in relieving and anti-allergy effect, the preparation method is simple and convenient, safety is high, and the composition is suitable for industrial production. Wide market application prospects are realized.

Description

Technical Field

[0001] This invention relates to the field of daily chemical technology, and more particularly to the application of a cosmetic raw material, specifically to the application of a composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products. Background Technology

[0002] With the accelerated pace of life and increased work and life pressures, the incidence of atopic dermatitis is on the rise year by year. The formation of atopic dermatitis (also known as atopic eczema) is closely related to factors such as allergy-related immune abnormalities and impaired skin barrier function. Its mechanism can be simply understood as follows: 1. Immune imbalance is the core: Patients with atopic dermatitis have immune system disorders, especially overactivation of the Th2 immune response. When exposed to allergens (such as dust mites, pollen, certain foods, etc.), the immune system mistakenly identifies them as "harmful substances," triggering a series of immune responses: immune cells (such as mast cells and basophils) release inflammatory mediators such as histamine; specific IgE antibodies are produced, continuously triggering allergic reactions, leading to skin inflammation and itching; 2. Impaired skin barrier function: The stratum corneum structure of the patient's skin is incomplete, the moisturizing ability is reduced, and the barrier function is weak. This not only makes it easier for external allergens and irritants to penetrate the skin and trigger an immune response, but also leads to increased skin moisture loss, exacerbating symptoms such as dryness, peeling, and itching, forming a vicious cycle of "itching - scratching - worsening skin barrier - more severe allergies." 3. The combined effect of genetics and environment; genetic factors (such as carrying susceptibility genes related to immunity and skin barrier) increase the risk of disease, while environmental factors (such as dry climate, pollution, infection, etc.) may induce or aggravate symptoms.

[0003] In simple terms, allergic reactions triggering immune dysregulation are the "internal cause," while a weakened skin barrier is the "external contributing factor." Together, these two factors lead to the recurrence of atopic dermatitis.

[0004] Currently, most products on the market work by adding chemical bactericides, hormones, and anti-inflammatory drugs. Although they can reduce inflammation and allergies in a short time, they are highly irritating to the skin, and long-term use will increase the burden on the skin.

[0005] Therefore, plant-based ingredients are used to control skin allergies and improve skin health.

[0006] In the existing technology, licorice extract has been widely used in anti-allergy products, but the following problems exist:

[0007] 1. A single ingredient has limited effect at low concentrations, and may cause irritation at high concentrations;

[0008] 2. Insufficient speed of relief for transient sensitivity symptoms (such as burning sensation);

[0009] 3. It has a weak inhibitory effect on neurosensitive receptors (such as TRPV1 receptor activation). Summary of the Invention

[0010] To overcome the shortcomings of the prior art, the present invention provides an application of a composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products. The present invention is stable in nature, and when added to various products, it has long-lasting anti-allergic, anti-inflammatory, and anti-neuroinflammatory effects.

[0011] To achieve the aforementioned inventive objectives, the present invention employs the following technical solution:

[0012] The use of a composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products, wherein the composition is added at 0.005% to 10% (w / w) to a facial mask, serum, skin cream, lotion, or sunscreen personal care product, and the composition comprises the following components by weight:

[0013] Glycyrrhizin or glycyrrhizin 1-99%;

[0014] Glycyrrhizic acid and its salts: 1-99%.

[0015] The application of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products, wherein the weight ratio of glycyrrhizin or glycyrrhizin to glycyrrhizic acid and its salts is 1:99 to 99:1.

[0016] The application of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products, wherein the purity of the raw material of glycyrrhizin or glycyrrhizin is 5-99.99%.

[0017] The application of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products, wherein the purity of the raw materials of glycyrrhizic acid and its salts is 5-99.99%.

[0018] By employing the technical solution described above, the present invention has the following advantages:

[0019] This invention involves compounding glycyrrhizin or glycyrrhizin with glycyrrhizic acid and its salts in a predetermined ratio. The components are derived from the natural plant licorice, whose active ingredients have multiple functions such as antibacterial, anti-inflammatory, sebum-balancing, redness-reducing, and anti-allergic effects. The prepared composition is then added to personal care products such as masks, serums, skin creams, face creams, and sunscreens at a ratio of 0.005% to 10% (w / w). This invention achieves synergistic effects, and the resulting composition has significant effects in soothing and reducing allergies. Furthermore, the preparation method is simple, safe, and has broad market application prospects. Detailed Implementation

[0020] The present invention can be explained in more detail through the following embodiments, but the present invention is not limited to the following embodiments;

[0021] The present invention relates to the application of a composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products. The composition is added at 0.005% to 10% (w / w) to a facial mask, serum, skin cream, lotion, or sunscreen. The composition comprises the following components by weight:

[0022] Glycyrrhizin or glycyrrhizin 1-99%;

[0023] Glycyrrhizic acid and its salts: 1-99%.

[0024] In practice, the weight ratio of glycyrrhizin or glycyrrhizin to glycyrrhizic acid and its salts is 1:99 to 99:1.

[0025] Furthermore, the purity of the raw material for the glycyrrhizin or glycyrrhizin is 5-99.99%.

[0026] Furthermore, the purity of the raw materials for the glycyrrhizic acid and its salts is 5-99.99%.

[0027] In specific implementation of this invention, when glycyrrhizin or glycyrrhizin glycoside is combined with glycyrrhizic acid and its salts (glycyrrhizic acid or dipotassium glycyrrhizate or ammonium glycyrrhizate) in the above mass ratio, it can achieve rapid and long-lasting anti-allergic, anti-inflammatory, and anti-neuroinflammatory effects.

[0028] It should be noted that the glycyrrhizin, glycyrrhizin, glycyrrhizic acid, dipotassium glycyrrhizate, and ammonium glycyrrhizate involved in this invention are all provided by Luoyang Lansli Technology Co., Ltd.

[0029] The preparation method of the composition in this invention is as follows:

[0030] (1) Determine the composition components and proportions;

[0031] (2) Weigh and mix: Weigh out glycyrrhizin or glycyrrhizin, glycyrrhizic acid or its salts according to the proportion, put them into a three-dimensional swing mixer, and mix for 2 to 4 hours to ensure that they are mixed evenly.

[0032] (3) Crushing and sieving: Put the mixed product into a crusher and crush for 15 to 30 minutes until it is completely crushed. Then pass it through a 60 to 120 mesh sieve to obtain the powder form of the composition.

[0033] (4) The composition can be dissolved in water, ethanol or polyol to form a product with a solid content of 10% to 50%, stirred evenly and then homogenized; the inlet pressure is 0.2 MPa to 0.5 MPa, the homogenization pressure is 20 MPa to 30 MPa, and the feed flow rate is set to 5 L to 15 L per hour; the number of homogenizations is set to 1 to 4 times, each homogenization lasts 5 to 10 minutes, and the interval between each homogenization is 5 minutes to avoid continuous operation of the equipment; after homogenization, the anti-allergy and soothing composition of the present invention is obtained in liquid form; personal care products (based on the weight of the composition powder) can be added in the range of 0.005% to 10% (w / w).

[0034] Specific embodiments of the present invention are as follows:

[0035] Example 1

[0036] The composition is prepared as follows:

[0037] (1) Determine the weight ratio of effective substances: glycyrrhizin 20%, dipotassium glycyrrhizate 80%.

[0038] (2) Weigh 200g of glycyrrhizin (purity ≥90%) and 800g of dipotassium glycyrrhizate (purity ≥65%); place the two components in a three-dimensional rocking mixer and mix for 2-4 hours.

[0039] (3) Place the mixed product into a pulverizer and pulverize for 15 to 30 minutes until it is completely pulverized. Then pass it through a 60 to 120 mesh sieve to obtain the powder form of the composition.

[0040] (4) Dissolve the powder of this composition in hexanediol to form a product with a solid content of 10% to 50%; after stirring evenly, homogenize; the inlet pressure is 0.2 MPa to 0.5 MPa, the homogenization pressure is 20 MPa to 30 MPa, and the feed flow rate is set to 5 L to 15 L per hour; set the number of homogenizations to 1 to 4 times, each homogenization lasts 5 to 10 minutes, and the interval between each homogenization is 5 minutes to avoid continuous operation of the equipment; after homogenization, the anti-allergy and soothing composition of the present invention is obtained in liquid form; personal care products (based on the weight of the powder composition) can be added in the range of 0.005% to 10% (w / w).

[0041] Example 2

[0042] The composition is prepared as follows:

[0043] (1) Determine the weight ratio of effective substances: glycyrrhizin 45%, glycyrrhizic acid ammonium salt 65%.

[0044] (2) Weigh 450g of glycyrrhizin (purity ≥90%) and 650g of glycyrrhizic acid ammonium salt (purity ≥60%); place the two components in a three-dimensional swing mixer and mix for 2 to 4 hours. Put the mixed product into a pulverizer and pulverize for 15 to 30 minutes until it is completely pulverized. Then pass it through a 60 to 120 mesh sieve to obtain the powder form of the composition.

[0045] (3) Place the mixed product into a pulverizer and pulverize for 15-30 minutes until it is completely pulverized. Then pass it through a 60-120 mesh sieve to obtain the powder form of the composition.

[0046] (4) Dissolve the powder of this composition in hexanediol to form a product with a solid content of 10% to 50%; after stirring evenly, homogenize; the inlet pressure is 0.2 MPa to 0.5 MPa, the homogenization pressure is 20 MPa to 30 MPa, and the feed flow rate is set to 5 L to 15 L per hour; set the number of homogenizations to 1 to 4 times, each homogenization lasts 5 to 10 minutes, and the interval between each homogenization is 5 minutes to avoid continuous operation of the equipment; after homogenization, the anti-allergy and soothing composition of the present invention is obtained in liquid form; personal care products (based on the weight of the powder composition) can be added in the range of 0.005% to 10% (w / w).

[0047] Example 3

[0048] The composition is prepared as follows:

[0049] (1) Determine the weight ratio of effective substances: glycyrrhizin 80%, glycyrrhizic acid 20%.

[0050] (2) Weigh 800g of glycyrrhizin (purity ≥90%) and 200g of glycyrrhizic acid (purity ≥60%); place the two components in a three-dimensional swing mixer and mix for 2 to 4 hours. Put the mixed product into a pulverizer and pulverize for 15 to 30 minutes until it is completely pulverized. Then pass it through a 60 to 120 mesh sieve to obtain the powder form of the composition.

[0051] (3) Place the mixed product into a pulverizer and pulverize for 15 to 30 minutes until it is completely pulverized. Then pass it through a 60 to 120 mesh sieve to obtain the powder form of the composition.

[0052] (4) Dissolve the powder of this composition in hexanediol to form a product with a solid content of 10% to 50%; after stirring evenly, homogenize; the inlet pressure is 0.2 MPa to 0.5 MPa, the homogenization pressure is 20 MPa to 30 MPa, and the feed flow rate is set to 5 L to 15 L per hour; set the number of homogenizations to 1 to 4 times, each homogenization lasts 5 to 10 minutes, and the interval between each homogenization is 5 minutes to avoid continuous operation of the equipment; after homogenization, the anti-allergy and soothing composition of the present invention is obtained in liquid form; personal care products (based on the weight of the powder composition) can be added in the range of 0.005% to 10% (w / w).

[0053] Performance testing

[0054] Test samples: The anti-allergic and soothing compositions prepared in Examples 1 to 3 above were selected, as well as the control group consisting of glycyrrhizin (glycoside), dipotassium glycyrrhizate, and pure water; all the above samples were prepared into 1% solutions with 50% 1,2-hexanediol as the solvent.

[0055] Test method for soothing effect of skin nerve inflammation stimulation: 90 healthy volunteers were selected and divided into 9 groups. 1% capsaicin-hexanediol solution was applied to the inner forearm of each volunteer in 2 areas, A and B, each 2cm×2cm. The skin was observed for irritation reactions such as erythema, itching, and stinging. After a positive reaction, one of the areas was treated with the combination of Examples 1, 2, and 3. The control group was treated with glycyrrhizin (glycoside), dipotassium glycyrrhizate, and pure water. The irritation-releasing effect was recorded.

[0056]

[0057] Test results: In the skin irritation test, none of the samples in the examples caused skin irritation in the volunteers, indicating good safety.

[0058]

[0059] Application Examples

[0060] The anti-allergic and soothing composition of this invention can be applied to various cosmetics, such as serums and face creams. Specific application examples are as follows:

[0061] 1. Anti-allergy and soothing serum

[0062] Formula composition (by weight percentage)

[0063]

[0064] Preparation method:

[0065] Add deionized water to the mixing container and start stirring at a speed of 200-300 rpm. Add glycerin and sodium hyaluronate in sequence, and continue stirring until completely dissolved, which takes about 10 minutes.

[0066] Next, add panthenol and allantoin, stir well, and ensure that all ingredients are fully mixed.

[0067] Raise the temperature to 40-45°C, add the composition from Example 2, and stir for 15 minutes to ensure uniform dispersion of the composition.

[0068] Finally, cool to room temperature, add phenoxyethanol, stir for 5 minutes, and mix well to obtain the anti-allergy and soothing essence.

[0069] II. Anti-allergic and soothing face cream:

[0070] Formula composition (by weight percentage)

[0071]

[0072] Preparation method:

[0073] Prepare the oil phase and aqueous phase separately. The oil phase includes stearic acid, lanolin, and petrolatum. Place them in a container, heat to 75-85°C, and stir until completely melted and mixed evenly.

[0074] The aqueous phase, consisting of glycerol, ethylparaben, and deionized water, is placed in another container and heated to the same temperature as the oil phase, then stirred to ensure the components are dissolved evenly.

[0075] While stirring (300-400 r / min), slowly and uniformly add the oil phase to the aqueous phase while stirring continuously for 15-20 minutes until emulsification is complete and a uniform emulsion is formed.

[0076] Continue stirring to gradually cool the system to about 45°C, add triethanolamine, stir for 5 minutes, and adjust the pH value.

[0077] When the temperature drops to 40°C, add the composition of Example 2 and stir for 10 minutes to ensure uniform mixing.

[0078] Stop stirring and let the cream cool to room temperature naturally to obtain an anti-allergy and soothing face cream.

[0079] in conclusion:

[0080] This invention involves compounding glycyrrhizin or its glycosides with glycyrrhizic acid and its salts in a specific ratio, with glycyrrhizin (glycosides) comprising 1-99% and glycyrrhizic acid and its salts comprising 1-99%. This mixture contains two active ingredients in a weight ratio of 1:99 to 99:1. The purity of the raw materials is required to be 5%-99.99%. This component can be added at 0.005%-10% (w / w) to personal care products such as face masks, serums, skin creams, and sunscreens. The resulting anti-allergic and soothing composition exhibits significant effects in soothing and relieving allergies. Furthermore, the preparation method is simple, the safety is high, and it has broad market application prospects.

[0081] The components selected in this invention are derived from the natural plant licorice, and their active ingredients possess multiple functions such as antibacterial, anti-inflammatory, sebum-balancing, redness-reducing, and anti-allergic effects. The product preparation method of this invention is simple, requiring no complex instruments or equipment, and it exhibits strong market competitiveness in terms of safety, efficacy, overall quality, and cost-effectiveness, making it easy to promote.

[0082] The parts of this invention not described in detail are prior art.

[0083] The embodiments selected herein for the purpose of disclosing the inventive objectives are currently considered suitable; however, it should be understood that the invention is intended to include all variations and modifications of the embodiments that fall within the scope of this concept and invention.

Claims

1. The use of a composition of glycyrrhizin (glycoside) and glycyrrhizic acid and its salts in personal care products, characterized in that: The composition is added to a face mask, serum, skin cream, lotion, or sunscreen personal care product at a rate of 0.005% to 10% (w / w), and the composition comprises the following components by weight: Glycyrrhizin or glycyrrhizin 1-99%; Glycyrrhizic acid and its salts: 1-99%.

2. The application of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and their salts according to claim 1 in personal care products, characterized in that: The weight ratio of glycyrrhizin or glycyrrhizin to glycyrrhizic acid and its salts is 1:99 to 99:

1.

3. The application of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and their salts according to claim 1 in personal care products, characterized in that: The purity of the raw materials containing glycyrrhizin or glycyrrhizin is 5-99.99%.

4. The use of the composition of glycyrrhizin (glycoside) and glycyrrhizic acid and their salts according to claim 1 in personal care products, characterized in that: The purity of the raw materials for the glycyrrhizic acid and its salts is 5-99.99%.

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