126 results about "Dose effect" patented technology

A medical accelerator system is provided for simultaneous radiation therapy to all treatment fields. It provides the single dose effect of radiation on cell survival. It eliminates the inter-field interrupted, subfractionated fractionated radiation therapy. Single or four beams S-band, C-band or X-band accelerators are connected to treatment heads through connecting beam lines. It is placed in a radiation shielding vault which minimizes the leakage and scattered radiation and the size and weight of the treatment head. In one version, treatment heads are arranged circularly and connected with the beam line. In another version, a pair of treatment heads is mounted to each ends of narrow gantries and multiple such treatment heads mounted gantries are assembled together. Electron beam is steered to all the treatment heads simultaneously to treat all the fields simultaneously. Radiating beam's intensity in a treatment field is modulated with combined divergent and pencil beam, selective beam's energy, dose rate and weight and not with MLC and similar devices. Since all the treatment fields are treated simultaneously the dose rate at the tumor site is the sum of each of the converging beam's dose rate at depth. It represents the biological dose rate. The dose rate at d-max for a given field is the individual machine dose rate. Its treatment options includes divergent or pencil beam modes. It enables to treat a tumor with lesser radiation toxicities to normal tissue and higher tumor cure and control.

The invention discloses a method for determining the biotoxicity of atrazine by utilizing microcystis aeruginosa. The method comprises the following steps: A, cultivating the microcystis aeruginosa; B, preparing microcystis aeruginosa liquid; C, determining the response time of the chlorophyll fluorescence of the microcystis aeruginosa on the biotoxicity of the atrazine; and D, drawing the standard curve for determining the biotoxicity of the atrazine by utilizing the chlorophyll fluorescence of the microcystis aeruginosa, namely adding atrazine standard liquid with series concentration into the preparation liquid of the microcystis aeruginosa, completely mixing until the 'optimum response time' determined by the step C and determining the chlorophyll fluorescence intensity of the microcystis aeruginosa; and setting three parallel samples for each concentration, setting a blank sample by substituting aseptic distilled water for the sample, calculating the photosynthetic inhibition ratio, and finally drawing the 'dose-effect relation curve of atrazine concentration and photosynthesis inhibition ratio' to serve as the standard curve for quantitatively determining the biotoxicity of the atrazine by the chlorophyll fluorescence method of the microcystis aeruginosa. The method can determine the biotoxicity of the atrazine simply, conveniently and quickly, and is low in cost and environment-friendly.

The invention provides a bisbenzylisoquinoline compound in lindera aggregate and the preparation method thereof. The lindera aggregate dried root is used as the raw material and is extracted by using an alcoholic solvent, the extractant is produced into extracturm through decompressing concentration, after the extracturm is dissolved and suspended by water and acidified by dilute acid, the neutral component of the extracturm is removed by extraction with an organic solvent, the water phase is adjusted to the pH value of 10 by weak base, extraction is performed by the organic solvent after solvent recovery, the total alkaloid crude product is obtained, fine alkaloid crude is prepared after the crude product is resolved in alcohol and sedimentation process is performed by adding an amount of water, eluting parts are colleted after the chloroform-carbinol system elution and the water-carbinol gradient elution, and the compound can be prepared after removing the solvent by condensation. The compound is used for performing activity inhibition experiments to L1210 and K562 tumor cell strains, results show that both L1210 and K562 tumor cell strains have strong cell-toxicant activity and present dose-effect relationships. The compound can be applied to the preparation of anticancer drugs, and has the above structural formula.

The invention relates to an automatic quantitative dosing device under an oil well. In the device, the upper part of a charging pipe is connected with a communicating joint, and the lower part of the charging pipe is connected with a pump body joint of a dosing pump; a piston rod of the dosing pump is connected with a cam, a connecting rod and a motor in sequence; the motor is connected with a control circuit and a battery; a singlechip IC2 of the control circuit is connected with a dial switch S1; a triode Q2 is connected with a triode Q1; the Q1 is connected with the motor; and a power supply is connected with the triode Q1 through a voltage regulating chip IC1. The motor starting time interval and every dosing amount can be set according to the total dosing amount of the oil well, the piston rod of the dosing pump reciprocates to spray a liquid medicine into the annular space of an oil sleeve during dosing, and the dosing pump stops working and waits for the next dosing time when a designed medicine amount is reached so that automatic timing and quantitative continuous dosing are realized. The automatic quantitative dosing device has a high automatic degree, a good dosing effect, low construction cost and high long-term working reliability, and is easy to operate; and underground dosing can be realized without detaching an instrument or performing pipe column operation.

The invention relates to a composition for interfering or treating diabetes and a preparation method of the composition. The composition comprises raw materials such as a DFEM culture medium (namely a medical and edible mushroom fermentation culture medium) and an edible mushroom fermentation seed liquid. The composition provided by the invention is definite in dose-effect for regulating the blood sugar level, and experiments in vitro show that the composition is higher in stability compared with the prior art.

The invention belongs to a biological dosemeter of ionizing radiation, in particular to application of high mobility group box 1 (HMGB1) as a biological dosemeter of ionizing radiation. After isolated cells especial blood is radiated, the increase of HMGB1 content is proportional to received ionizing radiation dose to form certain dose-effect relation, and the ELISA (Enzyme-Linked Immuno Sorbent Assay) method and other simple, convenient and feasible methods can be adopted for rapid detection after 24 h of irradiation. Thus, the HMGB1 can be used as the biological dosemeter of ionizing radiation; moreover, the HMGB1 can be used for measuring the biological radiation dose of human bodies and animals exposed to ionizing radiation.

The invention discloses a quality control method based on a dose-effect color card for anti-inflammatory and analgesia action of qi-stagnation and stomachache granules. According to the quality control method, correlation between the quality and the medicine effect of the qi-stagnation and stomachache granules is evaluated through construction of a fingerprint of the qi-stagnation and stomachache granules and evaluation of the anti-inflammatory and analgesia action of the qi-stagnation and stomachache granules; a dose-effect relationship equation is constructed; the dose-effect color card for the anti-inflammatory and analgesia action of the qi-stagnation and stomachache granules is successfully constructed; and the anti-inflammatory and analgesia action can be intuitively reflected in a form of the 'color card' by detecting the relative peak area of specific components in the qi-stagnation and stomachache granules. The quality control method can be used for evaluating the anti-ulcer action degree and the quality of the qi-stagnation and stomachache granules.

The invention belongs to an ionizing radiation biodosimeter, and concretely relates to an application of a cyclin G1 (CCNG1) gene as the ionizing radiation biodosimeter. After low-dose ionizing radiation of a human lymphoblast and the radiation of mammals, the increase of the expression level of the mRNA of the CCNG1 gene in a peripheral blood lymphocyte is directly proportional to the applied ionizing radiation dose, there is a certain dose-effect relation, and a real-time fluorescent quantitative PCR method is adopted 24h and 48h after the radiation to realize the fast and simple quantitative detection, so the CCNG1 can be used as a biodosimeter of a low-dose ionizing radiation range, and the dose of the low-dose ionizing radiation to the human bodies and the mammals can be evaluated through a CCNG1 gene expression quantitative-analysis method.

The invention discloses a transistor structure with reinforced total dose radiation resistance. An active area is divided by a grid area into a drain area, a source area and a flotation area, the grid area surrounds the drain area completely, a closed parasitic circuit from a source area to a drain area is eliminated, and a total dose radiation resistance reinforcement function is realized. The structure disclosed by the invention solves the problem of parasitic current leakage, which is caused by a total ionizing dose effect, between the source and drain areas, realizes small-size transistorand effectively reduces grid capacitance, thereby better meeting requirements of the high-speed, low-power consumption and reinforced-radiation resistance integrated circuits.

The invention discloses a detection method of anti-tumor activity of dendrobium huoshanense refined polysaccharide. The detection method comprises an in-vitro anti-tumor detection method and an in-vivo anti-tumor activity detection method; the inhibition rate of the dendrobium huoshanense refined polysaccharide on tumor cells is calculated through the in-vitro anti-tumor detection method; a dose-effect curve is drawn according to different concentration inhibition rates, and the half inhibitory concentration IC50 of the tumor cells is calculated; the in-vivo growth inhibition effect of the dendrobium huoshanense refined polysaccharide on a C57BL / 6J mouse in-vivo transplantable mouse lung cancer LLC tumor is detected through the in-vivo anti-tumor activity detection method; an in-vitro experiment shows that the dendrobium huoshanense refined polysaccharide has an obvious dose effect on an in-vitro anti-tumor effect; an in-vivo activity experiment shows that the dendrobium huoshanense refined polysaccharide has good anti-tumor activity and a relatively good dose-effect relation; the growth of a mouse lung cancer transplantable tumor can be remarkably inhibited and the dendrobium huoshanense refined polysaccharide has an obvious in-vivo anti-tumor effect; two experiment methods are combined so that the detection of the anti-tumor activity of the dendrobium huoshanense refined polysaccharide is more accurate.

The embodiment of the invention discloses a method and device for determining a total dose effect defect model. The method for determining the total dose effect defect model comprises the following steps: constructing a transistor three-dimensional structure model; obtaining an initial hole trapped charge parameter to the transistor three-dimensional structure model to form an initial radiation defect damage model; calculating an initial normalized excess base current of the initial radiation defect damage model based on a physical model and a numerical solution method set in the transistor three-dimensional structure model; determining that the initial normalized excess base current is a preset initial normalized excess base current; and determining hole trap charge parameters corresponding to different radiation dose points according to the initial hole trap charge parameters and a preset proportional relation between normalized excess base currents of every two adjacent radiation dose points, and forming a total dose effect defect model under the different radiation dose points.

The invention discloses a method for testing toxicity of environmental estrogen on whitebait embryonic development. The method of the invention utilizes the sensitivity of embryo to the simulation of environmental pollutant or chemical matter to perform a test under semi-static state on whitebait embryo which is exposed in standard diluted aqueous solution of subject having a series of concentrations. The test lasts about 30 days, begins as exposing a live embryo at the blastula stage in the aqueous solution of subject, and ends with hatching all embryos in a control group and an exposed group. The toxicity endpoint contains death, monstrosity and delayed hatching. The method comprises the steps of confirming the toxicity of the subject on the whitebait embryonic development by observing the toxicity endpoint of the exposed group and comparing with the control group; researching on the influence of two natural estrogens E2 and EE2 on the whitebait embryo-yolk sac stage so as to confirm the toxic dose-effect relationship of the natural estrogens to the whitebait embryonic development, and evaluating the potential risk of this type of fish exposed under the estrogen with environmental concentration.

The invention provides a quality control method of gastrointestinal motility promoting power of qi-stagnation and stomachache granules based on a dose-effect color card. The quality control method comprises the following steps of: establishing a qi-stagnation and stomachache granule fingerprint spectrum and evaluating the acting drug effect of the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules; and evaluating the relevance of the mass of the qi-stagnation and stomachache granules and the drug effect and establishing a dose-effect relational equation, so as to successfully construct an acting dose-effect color card of the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules. Therefore, a gastrointestinal motility promoting power drug effect can be directly reflected in a color card manner through detecting a specific component relative peak area in the qi-stagnation and stomachache granule; the quality control method can be used for evaluating the acting degree and quality of expressing the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules.

The invention belongs to the technical field of biological detection, in particular to a biochemical method for detecting the ionizing radiation dose. According to the principle that a cell cycle can be interfered by ionizing radiation and cytochalasin B can retard cell division but cannot retard cell nucleus division, after different doses of gamma rays are used for irradiating lymphocyte, a certain quantity of cytochalasin B is added for processing so as to detect the four-core rate and the double-core rate of the lymphocyte irradiated with different doses of gamma rays. An experiment result shows that the four-core rate of the irradiated lymphocyte and the irradiated dose are in a linear dose-effect relationship within a low-dose range of 0-6.4cGY, a relevant coefficient is 0.957, and the radiation excitability effect is presented; and within a high-dose range of 0.4-20Gy, the double-core rate of the irradiated lymphocyte and the irradiated dose are in an exponential equation dose-effect relationship, the relevant coefficient is 0.978, and the radiation damage effect can be favorably reflected. The biochemical method for detecting the ionizing radiation dose is visual in detection indexes, is simple to operate, is quick and economic and is accurate in detection result.

The invention relates to a one-dose one-bath low-temperature type pre-treatment compound preparation which comprises the following components in mass percentage: 35.3-52.1% of hydrogen peroxide additive, 11.1-23.1% of peroxysulphate, 2.7-8.0% of sodium hydroxide, 5.5-15.4% of multifunctional additives, 11.8-28.6% of metasilicic acid alkali metal and 2.7-8.0% of surface active agent. According to the compound preparation, multiple functions, such as a refining function, a bleaching function, a permeating function and the like, are integrated into a whole; one-dose effect of a pre-treatment agent is realized; inconvenient operation caused by a plurality of dosage forms and troubles, such as time consumption, labour consumption, material consumption and the like, in the production process are avoided; the use amount of auxiliary additives, such as sodium hydroxide and the like, is reduced; annealing, boiling and bleaching processes in pre-treatment are combined into the one-bath method; the process flow is simplified; simultaneously, the pre-treatment temperature is reduced; the comprehensive production cost is also reduced; and the one-dose one-bath low-temperature type pre-treatment compound preparation disclosed by the invention has good application prospect.

The invention relates to a qi stagnation stomachache particle anti-ulcer quality control method based on a dose-effect color card. According to the quality control method, by means of establishment of a qi stagnation stomachache particle fingerprint spectrum and efficacy evaluation of the qi stagnation stomachache particle anti-ulcer effect, the quality and efficacy relevance of qi stagnation stomachache particles is evaluated, a dose-effect relation equation is established, the qi stagnation stomachache particle anti-ulcer action dose-effect color card is successfully established, and thus it is achieved that by detecting the relative peak area of specific ingredients in the qi stagnation stomachache particles, the anti-ulcer efficacy of the qi stagnation stomachache particles can be visually reflected in the color card mode, and the quality control method can be used for evaluating the degree of the anti-ulcer effect performed by the qi stagnation stomachache particles and the quality of the qi stagnation stomachache particle.

The present invention relates to a novel hydrophilic-lipophilic gel membrane and a preparation method thereof; the dual hydrophilic gel is prepared from a styrene-isoprene-styrene segmented copolymer as a framework material, and also comprises oil and an organic fibrinolytic agent which have the good compatibility with the copolymer, as well as an anti-oxygen, and a hydrophilic / water-absorbing assistant. The membrane has the big characteristic of being capable of being used as a drug carrier under a condition that a surface active agent is not added, a water-soluble drug can be added, a lipophilic drug also can be added, the universality as the drug carrier is expanded, a defect that only the water-soluble drug can be added into a conventional hydrophilic gel, and only the lipophilic drug can be added into a conventional lipophilic gel is solved, each functional component can be kept in a dissolved state and can not be prone to absorb, and a dose-effect ratio relationship (have to meet) of drug components can be met; the novel hydrophilic-lipophilic gel membrane can enhance the transdermal action of the drug components to enable the drug components to fast penetrate through the skins within a short time to be absorbed.

The invention belongs to the field of environment pollution detection technology and relates to a method of establishing a Hormesis dose-effect fitting model, namely a Bilogistic model. The method comprises the following steps: (1) analyzing the stability of a compound; (2) recovering and culturing strains; (3) conducting toxicity test including acute toxicity test and chronic toxicity test; (4) calculating the inhibition ratio of the compound analyzed in the step (1) to the strains recovered and cultured in the step (2) by applying the experiment result obtained in the step (3), and conducting toxicity representation by taking inhibition ratio as an index; and (5) fitting the toxicity data to obtain the Bilogistic model. The data fitting is more convenient through the model; parameters in the model are initialized simply; the model is established based on a receptor mechanism hypothesis, thereby having great biological significance; good fitting can be conducted under the condition of high stimulatory effect; the Hormesis effect can be effectively guided to the application in the drug design.

The invention discloses an IBIS-based integrated circuit total dose effect modeling method. The IBIS-based integrated circuit total dose effect modeling method comprises the steps of performing irradiation on an original electronic device by adopting different target accumulated doses; performing data measurement and model extraction on the irradiated original electronic device, and establishing an IBIS model database of the electronic device under all the target accumulated doses; under the condition of giving a total irradiation dose D, performing interpolation operation on the established model database of the device according to the total irradiation dose D to obtain VI and VT interpolation data under the irradiation dose, and building an IBIS model according to the interpolation data, namely, an IBIS irradiation total dose effect model of the device under the irradiation dose. According to the method, the influence of irradiation conditions on PCB signal integrity is considered based on original PCB signal integrity analysis, and model support is provided for performing simulation analysis of PCB signal integrity problem under the irradiation condition.

The invention relates to a compound combination with an effect of synergistically scavenging radicals. Active trace detection is carried out by adopting a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay; the synergistic effects (combination coefficient, CI) of two groups of antioxidant ingredients are evaluated by adopting a dose-effect analysis method on the basis of a median effect principle; a group of compounds for synergistically scavenging the radicals, namely calycosin and isoferulic acid are screened from astragalus membranaceus and cimicifugae foetidae; methanol solutions of the calycosin and the isoferulic acid are combined according to different dose ratios (3:1, 2:1, 1:1, 1:2, or 1:3), so as to determine the DPPH radical scavenging capacity. Thus, the calycosin and the isoferulic acid display the best synergistic effect under the condition that the dose ratio is 1:1.

The invention provides a processing method and a processing device for efficacy of combined medicine. The processing method comprises: obtaining a dose-effect curved band of expected additive effect of combined medicine; obtaining an actual dose-effect relationship curve formed by variation of actual effect value of the combined medicine with variation of dosage of a certain target component medicine in the combined medicine; comparing position relationships of the actual dose-effect relationship curve and the dose-effect curved band, and when the actual dose-effect relationship curve is above the dose-effect curved band, efficacy output of the combined medicine being synergy; when the actual dose-effect relationship curve is below the dose-effect curved band, efficacy output of the combined medicine being antagonism; and when the actual dose-effect relationship curve is in the dose-effect curved band range, the efficacy output of the combined medicine being addition. The processing method solves a problem in the prior art that efficacy cannot be accurately detected when multiple medicines are used in a combined manner. The method can be widely applied in research and development of compound medicines, toxicologic study, efficacy and safety evaluation of the combined medicine, and environmental evaluation.

The invention discloses a method for analysis of proanthocyanidins induced liver cancer cell autophagic death and application, and the human liver cancer cell HepG2 cell is used for experiment for determination of effects on HepG2 cell proliferation, dose effect and time effect of induction of HepG2 cell autophagic death of proanthocyanidins, content of intracellular ROS (reactive oxygen species and high active oxygen radicals), cell cycle distribution and mitochondrial membrane potential. Results confirm that the proanthocyanidins can induce human liver cancer cell HepG2 cell autophagic death by stimulating of the ROS pathway, and the results are applied to the prevention and treatment of liver cancer.

The invention discloses an application of oxymatrine in medicines for treating neonatal hypoxic ischemic brain damages. An experiment result shows that oxymatrine has a certain dose-effect correlation when used in a safe dose range; when the dose is 120mg / kg of body weight, the volume of ischemia area cerebral infarction and neuron apoptosis rate can be reduced; pathological damages to brain tissues can be relieved; the activity of antioxidase in the brain tissues can be improved; and the content of malondialdehyde is lowered. The oxymatrine has the effects of preventing injuries and deaths caused by neonatal hypoxic ischemic brain damages and promoting neural functional recovery.

The invention relates to the technical filed of medical apparatuses, in particular to an exclusive dosing device for a gynecology department. The device comprises a main tube body, a piston componentand expanding components; the invention provides an exclusive dosing device for the gynecology department, a means that the expanding components are arranged outside the main tube body is adopted, expanding plates are connected with support rods, the expanding rods are subject to a torsional spring effect to act on two sides of the vagina, and the vagina is expanded and opened; a sleeve ring slides along the main tube body and is subject to a limit effect of a clamping block to effectively avoid slipping backward, so that after the vagina is expanded, a doctor can push medicine confidently, and the dosing effect is ensured.

A topical opioid paradigm was developed to determine analgesic peripheral effects of morphine. Topical morphine as well as peptides such as [D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAMGO) produced a potent, dose-dependent analgesia using the radiant heat tailflick assay. The topical drugs potentiated systemic agents, similar to the previously established synergy between peripheral and central sites of action. Local tolerance was rapidly produced by repeated daily topical exposure to morphine. Topical morphine tolerance was effectively blocked by the N-Methyl-D-Aspartate (NMDA) receptors antagonist MK801 and ketamine given either systemically or topically. NMDA receptor antagonists reversed pre-existing morphine tolerance. The activity of topical NMDA antagonists to block local morphine tolerance suggests that peripheral NMDA receptors mediate topical morphine tolerance. Morphine was cross tolerant to [D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAMGO), but not to morphine-6 beta -glucuronide, implying different mechanisms of action. These observations have great importance in the design and use of opioids clinically. Topical pharmaceutical compositions comprising an analgesic that functions through an opiate receptor and an NMDA receptor antagonist for producing analgesia without inducing tolerance are described.

The invention relates to the technicalfield of pneumology department dosing devices, and discloses a portable pneumology department dosing device. By adjusting the spiral-in depth and position of thelower end of the micro channel mechanism of a charging container, adjustment ofthe length of a capillary supply pipe extending into the lower channel isachieved,thusthe flow resistance of medicine liquid in the capillary supply pipe isadjusted, the adjustment of the atomization rate of different viscosity medicine liquid can be well achieved, better atomization effect is achieved, it is guaranteedthat the concentration of the medicine liquid in atomized airflow is in a better range, and the treatment effect is improved; the principle of venturi tube is adopted to achieve the atomization effect on the medicine liquid, stability and reliability are achieved, the service life is long, when an air pump sprays air flow to the contraction section at the lower end of a venturi tube assembly, thenegative pressure effect at anegative pressure cavity of the venturi tube assembly makes the medicine liquid enter the venturi tube assembly through the capillary supply pipe and the lower channel ofthe micro channel mechanism and form a mist shape, the effect of atomization treatment can be ensured, and the dosing effect and energy of breathing are improved.

The invention relates to the usage of a 2',5',6',7'-tetrahydroxyflavanonol and the derivative in treating pyohemia, belonging to flavanonol compound THF, which is extracted and separated from baikal skullcap root of Chinese herbal medicine. Through experiment showing, the THF has the advantages that: the THF has direct neutralization effect and reveals better dose effect relationship; the THF also reveals better dose effect relationship upon inhibition of RAW 264.7 cells activation LPS stimulation; the THF can lower LPS level in blood of LPS blood symptom model animal in vivo; the THF also has obvious protection effect upon bacterial sepsis model mouse caused by heat-inactivation escherichia coli with lethal dose; the THF has good application prospect under the condition of lacking effective means treating pyohemia in prior study.

The invention discloses a method for observing a microtubule structure of a cytoskeleton in a liver tissue of animals. The method comprises the following steps: (1) cleaning the liver tissue of animals with PBS, fixing for 8-12h with 4v / v% of paraformaldehyde water solution, and carrying out paraffin embedding and serial sectioning; (2) dewaxing the obtained paraffin sections, and carrying out antigen retrieval, closing and fluorescently labeled antibody incubation; (3) for specimens sealed by glycerol, observing through a laser scanning confocal microscope within 24h, respectively exciting 488 and 4' 6-diamidino-2-phenylindole under 488nm and 405nm, and observing and shooting at once at room temperature in a dark room environment. The method is fast, simple, intuitive and accurate, is strong in practicality and extensibility, and can research the dose-effect changing relationship of the cytoskeleton under stress of pollutants.

The invention relates to a combination medicine based on active components in Fructus Aurantii. The combination medicine comprises, by mass, 9-72% of naringin, 9-72% of neohesperidin, 1-15% of naringenin, 1-15% of hesperetin, and the balance of a medicinal filling auxiliary material. Dose-effect experiments of the main medicine effect components comprising naringin, neohesperidin, naringenin and hesperetin in the traditional Chinese medicine Fructus Aurantii are carried out to carry out composition optimization, and the combination medicine can condition the rising and falling motion of the spleen and the stomach to promote gastrointestinal motility in order to treat gastrointestinal motility disorder, so the combination medicine can be used to treat the gastrointestinal motility disorder disease, and has god exploitation prospect. Compared with present gastric motility promotion medicines, the combination medicine has the advantages of convenient sources of the raw materials, substantial curative effect and no toxic or side effects.