41 results about "Dose effect" patented technology

The invention discloses a patient historical state-based anesthetic dose simulation evaluation system, which is characterized by comprising a multi-source data integration and preoperative physiological feature quantification layer, a dose effect relationship simulation layer and a risk evaluation and recommendation output layer. The method has the following advantages and effects that the personalized pharmacokinetics-pharmacodynamics model is constructed by integrating multi-source historical data of a patient, vital sign change tracks under different anesthetic doses are simulated, the recommended dose interval is generated based on multi-objective optimization, the change from experience dependence to accurate quantification is realized, and the accuracy of the recommended dose interval is improved. The problem of inaccurate anesthetic dosage prediction caused by individual differences is effectively solved, and the safety and effectiveness of an anesthesia scheme are remarkably improved.

The present application relates to the technical field of machine learning, and particularly relates to a preclinical drug experiment quality evaluation method based on machine learning, comprising: obtaining a plurality of experiment samples, each experiment sample comprising a dose level and an observation value of at least one biological index; determining a trend residual of each biological index of each experiment sample; determining a biological index evaluation weight sequence composed of quality evaluation weights of all biological indexes; determining a composite distance between any two experiment samples; determining a quality evaluation index of each experiment sample; and evaluating the quality of preclinical drug experiments based on the quality evaluation index of each experiment sample. By constructing a dose effect trend function, combining the trend residual and the weight, establishing a composite distance model fusing pharmacological trends, realizing adaptive selection of neighborhood parameters, improving the accuracy and stability of anomaly detection, overcoming the limitations of traditional machine learning LOF algorithm, and enhancing the evaluation reliability.

The invention discloses a method for evaluating damage of ionizing radiation to male sperm quality, which belongs to the technical field of reproductive biology, and comprises the following steps: establishing a dose-effect database model between ionizing radiation dose and male sperm quality based on a logistic regression model, determining a mapping relation between sperm quality rating and fertility recovery average time; collecting a to-be-detected semen sample exposed by ionizing radiation, comparing the to-be-detected semen sample with the dose-effect database model, evaluating the male sperm quality rating, and predicting the fertility recovery time based on the male sperm quality rating and the mapping relation.

The present application relates to the technical field of emergency material scheduling, and particularly relates to a multi-level inventory collaborative allocation method for medical materials under a sudden health event. The multi-level inventory collaborative allocation method for medical materials under a sudden health event comprises the following steps: S1: real-time acquisition of organophosphorus exposure data of a sudden health event area, construction of exposure concentration spatiotemporal distribution and spatiotemporal disability surface according to the organophosphorus exposure data; S2: acquisition of total drug demand of the sudden health event area and self-protection demand threshold of each inventory node according to the exposure concentration spatiotemporal distribution and the spatiotemporal disability surface, and acquisition of initial allocation data based on the self-protection demand threshold of each inventory node. The present application embeds the toxicology time-dose effect into the multi-level inventory collaborative decision, so that the allocation scheme can match the minute-level rescue window after organophosphorus poisoning, and the risk of irreversible injury and death caused by drug delay is significantly reduced.

The present application relates to a kind of culture medium preparation method for studying the influence of algal liquid secretion on arabidopsis growth, belong to the field of biotechnology.The method includes the preparation of solid medium, extraction of algal liquid secretion, preheating, four major steps of medium mixing.The liquid blue algae extracellular secretion is mixed into solid medium in specific method, the interference of microcystis aeruginosa liquid medium on experimental results is excluded by designing negative control, the "dose-effect" study of secretion to plant is carried out by adjusting the ratio of extracellular secretion and medium, the chemical stability of active component in extracellular secretion is inferred by designing stability experiment.The culture method designed in the application can be widely applied in other similar researches exploring the influence of microbial secretion on arabidopsis growth.

The invention discloses a pharmacodynamic test method for a cough relieving mixture, which comprises the following steps: constructing four core pharmacodynamic test sub-models containing ammonia water to cause young mouse cough, citric acid to cause young guinea pig cough, rabbit in-vitro trachea cilia mucus movement and young mouse trachea phenol red excretion and a body model of a test result analysis sub-model; each pharmacodynamic test sub-model is provided with a plurality of groups of test arrays and test individuals; pathogen data is imported to generate a simulated disease scene, and a corresponding drug sequence is called to intervene and collect physiological index change data; and multi-dimensional pharmacodynamic parameters are evaluated through the analysis sub-model, and a dose-effect relation curve and an evaluation report are generated. According to the invention, a parallel verification system for antitussive and expectorant tests is formed, the antitussive effective dose, the expectorant effective dose and the effective dose range under the dual action of the medicine are determined through multi-model cross validation, the accuracy degree of judging the effectiveness of the medicine is greatly improved, and a reliable method support is provided for evaluating the efficacy of the cough-stopping mixture.

The invention belongs to the technical field of disease prevention and control in aquaculture, and discloses application of arecoline derivatives in killing Bowden worms. A coarse screening experiment, a soaking toxicity test and a dose effect experiment prove that in coarse screening, 0.5 mg / L of the arecoline derivative is soaked for 90 min, so that the killing rate of the arecoline derivative on the bodworm reaches 75%, and the arecoline derivative is obviously superior to the other five kinds of arecoline and derivatives thereof such as triclabendazole and arecoline; a soaking toxicity test shows that after the arecoline derivative with the concentration of 0.7 mg / L is soaked for 90 min, the survival rate of the trachinotus ovatus is 100%, and no remarkable toxicity exists; a dose effect experiment further proves that the killing rate of 0.7 mg / L of the arecoline derivative on the boxworm is increased to 95.35%. The arecoline derivative has a remarkable effect of killing the boxworm, is high in safety to host fishes, has no obvious residual risk, can be further researched and developed to be special for preventing and controlling the boxworm in aquaculture, provides an effective scheme for solving culture diseases caused by the boxworm, and has a wide application prospect.

The application belongs to the technical field of three-dimensional integrated circuits, and discloses a through-silicon via link total dose effect evaluation method, equipment and medium based on an equivalent circuit model, wherein the method comprises the following steps: establishing a total dose equivalent circuit topology structure according to a through-silicon via structure; determining a parasitic electric parameter calculation equation in the total dose effect equivalent circuit; calculating the value of the electric parameter under normal conditions, and comparing the S parameter obtained through simulation calculation with the actually measured S parameter to verify the total dose effect equivalent circuit model; optimizing the design, extracting the electric parameter in the equivalent circuit under different radiation dose conditions; extracting the electric parameter change curve with the radiation dose; fitting the equation of the material attribute change with the radiation dose; and predicting the S parameter of the through-silicon via link at any radiation dose point. The equipment and medium are used for realizing the through-silicon via link total dose effect evaluation method based on the equivalent circuit model. The evaluation factors are comprehensive, the actual irradiation conditions can be better matched, and the performance of the through-silicon via link under the actual radiation conditions can be more accurately simulated.

A method for testing the total dose effect of a SiC MOSFET device, realizing verification of the complex total dose effect of the SiC MOSFET. The test steps sequentially comprise: testing a tested device before irradiation; performing annealing treatment on the tested device before irradiation; performing an irradiation test on the tested device; performing annealing treatment on the tested device after irradiation; performing test data analysis and processing on the tested device after irradiation. In the test process, threshold voltage shift caused by total dose radiation-induced defects and threshold voltage shift caused by near interface trap charges inherent near a SiC MOSFET interface are measured respectively, comprehensive analysis and calculation are carried out on the test result, the total dose effect resistance capability of the SiC MOSFET device can be given, and a certain guiding effect on device reinforcement is achieved.

The invention belongs to the technical field of computer systems based on specific calculation models, and particularly relates to a protamine dose-effect relationship modeling method, a protamine dose-effect relationship prediction system and a storage medium. The modeling method comprises the following steps: inputting clinical data from a single patient, wherein the clinical data comprises the administration dosage of protamine and a corresponding ACT measurement value; fitting different models suitable for a protamine dose-effect relationship based on the clinical data, and selecting an optimal model through cross validation; and re-training the optimal model by adopting all clinical data of a single patient to obtain the optimal model actually used for deployment. The invention also provides a system for predicting the protamine dose-effect relationship by using the model. Compared with a single model for predicting the protamine dosage-effect relationship, the method has higher accuracy, is beneficial to accurately controlling the protamine dosage of a patient, and has a very good application prospect in anticoagulation management in the perioperative period.

The invention relates to a board-level ionization total dose effect irradiation test method, and belongs to the technical field of space environment engineering. The method comprises the steps of plate-level electrical parameter testing before irradiation, ionization total dose effect irradiation under a device-level bias condition, room-temperature annealing, high-temperature annealing and plate-level electrical parameter testing after ionization total dose effect irradiation. According to the invention, the technical effect of carrying out the ionization total dose effect irradiation test with high efficiency, accuracy and low cost can be realized.

The invention discloses a double-antibody sandwich ELISA method for detecting the concentration of an HSC70 / STUB1 compound in serum, and belongs to the technical field of biomedical detection. The method specifically comprises the following steps: (1) coating; (2) washing; (3) sealing; (4) adding a sample; (5) adding a detection antibody; (6) developing; (7) terminating and detecting; and (8) quantitative analysis. The method disclosed by the invention can be used for carrying out high-sensitivity, high-specificity, accurate quantitative and high-throughput detection on the HSC70 / STUB1 compound in serum, and meanwhile, a reliable and convenient detection means is provided for researching a dose-effect relationship between the BP-3 environmental exposure level and the formation of the STUB1-HSC70 compound in vivo; an effective tool is provided for early diagnosis, risk prediction and mechanism research of related diseases, and the blank of the field in clinical transformation application is filled.

The invention discloses a method for evaluating the toxicity of dust affecting bacterial colony growth, which comprises the following steps: S1, preparing dust, crushing and grinding the dust, screening out dust with different particle sizes, and culturing escherichia coli in an LB culture medium; s2, preparing a liquid culture system; step S2.1, performing a dust exposure experiment; step S2.2, a dust leachate experiment is carried out; s3, preparing a solid culture system; s3.1, performing a dust exposure experiment; s3.2, a dust leaching solution experiment is carried out; s4, analyzing the physicochemical characteristics of the dust, and establishing a dose-effect relation model among the physicochemical components, the morphological characteristics, the particle size, the concentration and the bacterial colony growth toxicity effect of the dust by adopting a regression analysis method according to the data; the method has the advantages of rapidness, high efficiency, accurate data, low cost, wide application prospect and the like.

The invention discloses biomedical application of sodium caproate. The invention proposes and verifies that sodium caproate triggers zebra fish epilepsy in a low concentration range of 10-100 [mu] M and inhibits epilepsy in a high concentration range of 10-100 mM for the first time, that is, sodium caproate has a two-way dose effect in a zebra fish nervous system, so that the sodium caproate can be used for constructing a zebra fish epilepsy model and researching an anti-epilepsy mechanism based on the two-way dose effect.

The invention discloses an FPGA system reliability guarantee method for a nuclear power station based on a radiation effect, and belongs to the technical field of reliability design of a nuclear power station control system. According to the invention, radiation particle environment data are respectively obtained for different working condition stages in a non-accident state of the nuclear power station, and a foundation is laid for the accuracy of subsequent evaluation; secondly, based on the radiation environment data of each working condition, determining the most harsh working condition of the single event effect and the total dose effect so as to narrow the range of subsequent simulation and reduce the data processing overhead; next, the radiation effect under the most severe working condition is simulated through Monte Carlo simulation, the most sensitive device circuit corresponding to the two kinds of effects is directly positioned, and a clear target is provided for reinforcement measures; and finally, based on the reliability judgment result of the most sensitive device, a stage processing strategy is adopted for the most sensitive device circuit, so that the cost waste caused by excessive reinforcement is avoided, and the reliability guarantee of the high-efficiency cost ratio of the FPGA system is finally realized.

The application discloses a kind of based on radiation effect's FPGA system reliability guarantee method for nuclear power plant, belong to nuclear power plant control system reliability design technical field.The present application is aimed at different working condition stages under the non-accident state of nuclear power plant, respectively obtains radiation particle environment data, and lays foundation for the accuracy of subsequent evaluation;Second, based on the radiation environment data of each working condition, the most severe working condition of single particle effect and total dose effect is determined first, so as to reduce the scope of subsequent simulation and reduce data processing overhead;Then, the radiation effect under the most severe working condition is simulated by Monte Carlo simulation, and the most sensitive device circuit corresponding to the two effects is directly located, to provide a clear target for reinforcement measures;Finally, based on the reliability determination result of the most sensitive device, a hierarchical processing strategy is used for the most sensitive device circuit to avoid cost waste caused by excessive reinforcement, and finally realize the efficient reliability guarantee of FPGA system cost ratio.

The invention discloses application of 3-hydroxyglutaric acid in preparation of a medicine for preventing and / or treating hyperuricemia related diseases and the prevention and treatment medicine. The activity of 3-hydroxyglutaric acid capable of reducing the uric acid level in the body is found and confirmed for the first time, and the 3-hydroxyglutaric acid is pioneering discovery of new application of known substances; through rigorous dose effect relationship research, a'treatment window 'which is lower than a toxicity threshold value and can effectively reduce uric acid is determined. As an endogenous metabolic intermediate of a human body, the biocompatibility under low dosage is expected to be superior to that of a chemically synthesized medicine, and the potential side effect risk after long-term use is lower.

The invention relates to the technical field of pollutant treatment and environmental microorganisms, and provides a pollutant early warning method for preventing and controlling transmission of antibiotic resistance genes in a water environment. The conjugational transfer frequency of the antibiotic resistance gene is used as a quantitative core index, and after the quantitative core index and the environmental factor concentration of the pollutant are subjected to dose-effect relationship construction and analysis, a concentration range for promoting the propagation of the antibiotic resistance gene is obtained and is used as an early warning threshold value to early warn the propagation risk of the antibiotic resistance gene. According to the method, objectiveness and accuracy of threshold determination are achieved by combining the quantitative index of the transfer frequency or the conversion rate with the dose-effect relation, and subjective judgment is avoided.

The application relates to a method for system-level total dose effect test, which is used for solving the problem that the system radiation resistance performance is difficult to be accurately evaluated in the existing system-level total dose effect test process. The specific steps of the application are as follows: step 1, placing a test system on a rotating unit in an irradiation room; step 2, calibrating and recording the front end, rear end and rear end dose rate of 180 degrees of the test system by using a dose rate calibration device; step 3, irradiating according to the dose rate calibration result of step 2; step 4, segmenting the total dose, and obtaining the total dose D' total ; step 5, calculating the first irradiation time point t'1, the second irradiation time t'2 and the total irradiation time t' of each dose segment; and step 6, combining the calculation results of steps 4 and 5, and irradiating to n segments to complete the irradiation or irradiating the test system to the target total dose value. The test steps of the application are simple and easy to operate.​​

The application discloses a kind of SRAM total dose effect modeling simulation methods based on FDSOI device, it is related to integrated circuit technical field, the SRAM total dose effect modeling simulation methods based on FDSOI device of the embodiment of the application, the FDSOI device state after total dose irradiation simulation is saved to be used for the total dose effect simulation of SRAM circuit, the influence of total dose effect on the threshold voltage, mutual coupling capacitance, parasitic resistance etc. Electrical parameters of device in circuit can be considered comprehensively, so that the noise margin etc. Parameter of SRAM under irradiation condition is more accurate result analysis, this method can overcome the limitation of existing circuit level simulation.In TCAD directly carried out simulation can avoid the error caused by the device model of existing circuit level simulation, so that simulation result is more accurate.

According to the novel method for evaluating the toxic effect of the micro-plastic based on the shape characteristic dose, the morphological characteristic dose (mainly the surface area dose) is adopted, and compared with a traditional method with mass concentration as the dose, the real dose-effect relation of micro-plastic exposure can be better reflected; for some special biological effect indexes (such as growth inhibition and the like), volume doses can also be used. The invention reveals that the toxic effect of the micro-plastic not only depends on the mass concentration, but also directly related factors are the surface area and volume of the micro-plastic, which determine the contact area and encounter probability of the micro-plastic and an organism, so that the actual toxic effect caused by the micro-plastic can be reflected more truly.

This invention provides a concentration gradient cell culture system that solves the problem of large errors in manual drug addition and the difficulty in constructing a stable, continuous concentration gradient in studies on the control of osteoclast progenitor cell differentiation using propionic acid-GPR43. [Solution] The system comprises a housing assembly with an inner container, a first liquid storage cylinder 2, a second liquid storage cylinder 3, a tuned crossbeam 4, an adjustable screw rod 5, a flow-dividing branch pipe array frame, a spiral mixing unit, a porous diffusion plate, and a culture tray 9. The tuned crossbeam is driven by the adjustable screw rod to synchronously supply liquid from both liquid storage cylinders. After gradient distribution by the flow-dividing branch pipe array frame and mixing by the spiral mixing unit, the porous diffusion plate forms a continuous and stable propionic acid concentration gradient field on the culture tray. This avoids manual errors, provides accurate concentration gradients to RAW264.7 and BMMs cells in a single experiment, and supports the calculation of dose-effect curves and IC50, as well as the elucidation of the mechanism of osteoclast differentiation control by propionic acid-GPR43 signaling.

The invention relates to the field of focused ultrasound, in particular to a parameter positioning method and kit for inhibiting PCOS concurrent epilepsy based on focused ultrasound. The method comprises the following steps: acquiring different power and duty ratio combinations corresponding to a plurality of preset gears; according to the prior experiment data and the biological thermal model, predicting safety intervals of stimulation duration under different gears, and setting a plurality of experiment parameter combinations of different preset doses according to the safety intervals; performing ultrasonic stimulation on the experimental model based on the experimental parameter combination to obtain a biological response result; based on a preset dose effect relationship, according to the biological response result, respectively fitting a dose effect curve under each gear; and determining an optimal dose range of each gear based on the dose effect curve, and performing feasibility evaluation on the optimal dose range to determine an optimal parameter combination of focused ultrasound. On the premise of simple experimental operation, short period and low cost, a relatively accurate and effective ultrasonic parameter range is efficiently determined, and support is provided for personalized medical treatment.

This application relates to the field of focused ultrasound, and more particularly to a parameter localization method and kit for inhibiting PCOS-related epilepsy using focused ultrasound. The method includes: acquiring multiple preset power levels, each corresponding to different combinations of power and duty cycle; predicting the safe range of stimulation duration at different power levels based on prior experimental data and a biothermal model; setting several experimental parameter combinations with different preset doses based on the safe ranges; performing ultrasound stimulation on an experimental model based on the experimental parameter combinations and obtaining biological response results; fitting dose-response curves for each power level based on a preset dose-response relationship and the biological response results; determining the optimal dose range for each power level based on the dose-response curves, and evaluating the feasibility of the optimal dose range to determine the optimal parameter combination for focused ultrasound. This method efficiently determines a relatively accurate and effective range of ultrasound parameters while maintaining simple experimental operation, short cycle time, and low cost, providing support for personalized medicine.

The invention discloses an exosome miRNAs biomarker for evaluating the radiation exposure dose of a human body and application of the exosome miRNAs biomarker, the radiation exposure dose is calculated according to the dose effect relationship between the expression quantity of the exosome miRNAs and the radiation exposure dose, and the exosome miRNAs comprise miR-664b-3p, miR-551b-3p, miR-181b-5p, miR-125b-5p, miR-27a-3p, miR-18a-5p, miR-29a-3p and let-7i-5p. The method has the advantages of being convenient and minimally invasive in sampling, easy and convenient to operate and high in flux, the problems that in the prior art, the process is tedious, and consumed time is long can be solved, and the requirement for dose evaluation on large-scale crowds in nuclear and radiation emergencies is met.

The invention provides an analog-to-digital converter total dose effect evaluation method, system and device and a medium, and relates to the technical field of space environment effects, and the method comprises the steps: obtaining a total dose effect parameter; generating a behavior level evaluation model of the analog-to-digital converter according to the total dose effect parameter in combination with an initial evaluation model of the analog-to-digital converter; carrying out analogue simulation on the behavior level evaluation model to obtain simulation data under the action of the total dose effect; and generating a total dose effect evaluation report of the analog-to-digital converter according to the simulation data. According to the invention, the evaluation efficiency and precision of the total dose effect of the analog-to-digital converter are improved.

The application provides an application of an immune response biomarker in prognosis evaluation of a liver cirrhosis patient treated by mesenchymal stromal cells, relates to the field of biological medical technology, and the immune response biomarker comprises MX1 positive mononuclear cells or / and LGALS2 positive mononuclear cells, potential biomarkers LGALS2 positive mononuclear cells and MX1 positive mononuclear cells for predicting the dose-effect relationship of MSC treatment are screened, the proportion of MX1 positive mononuclear cells at a baseline of the liver cirrhosis patient is significantly increased (P<0.01) compared with a healthy control, and the proportion of LGALS2 positive mononuclear cells is significantly reduced (P<0.05); the change trend of the biomarker under the MSC dose and the regulation effect on other immune cell subgroups are identified through sequencing analysis, the dose-effect relationship of the immune regulation mediated by MSC can be accurately reflected, and patients with a low recurrence risk in MSC treatment prognosis are identified.

The invention belongs to the technical field of network pharmacology, and provides a traditional Chinese medicine compound dose-effect relationship network atlas construction method which comprises the following steps: collecting traditional Chinese medicine compound component-dose data and pharmacodynamic index data, and constructing a single-component dose-effect model and a compound multi-component collaborative model after preprocessing; predicting drug effect changes under different doses; establishing an initial network diagram of chemical, biological and dose nodes based on a prediction result, analyzing degree centrality and betweenness centrality of the initial network diagram, dividing communities through a Louvain algorithm, and dynamically adjusting edge weights to optimize the network; in combination with dose gradient and component knock-down experimental data, fitting experimental efficacy with a prediction result, calculating an error, then correcting a network edge weight and node relationship, and finally forming a dose-effect relationship network map; according to the method, the quantitative model and the dynamic network atlas are constructed by integrating multi-source data, and the systematic analysis of the dose-effect relationship of the traditional Chinese medicine compound is realized by combining experimental verification.

The invention provides a biological determination method for determining resistance of VIP3A gene-modified corn grassland spodoptera frugiperda based on a feed blending method, and relates to the technical field of determination of insect resistance of transgenic insect-resistant corn, and the biological determination method comprises the following three steps: preparing a sample, preparing a toxic feed, setting a control group, and performing biological determination and data acquisition. According to the method, highly uniform distribution of test substances in the feed is realized in a powder mixing manner, so that accurate dose effect analysis can be carried out, meanwhile, the steps of protein extraction, purification and substantial equivalence analysis are omitted, the process is simplified, and the cost is reduced. The method has the advantages that the method is particularly suitable for early-stage and rapid high-throughput screening of a large number of transgenic breeding materials, the real situation that pests eat transgenic plants in the field is simulated to the greatest extent under controllable experimental conditions, and the evaluation result has higher predictive value. The actual resistance performance of the pests in the field is more truly reflected.

The application discloses application of Ms4a1 in peripheral blood leukocytes in calculation of high-energy neutron radiation dose, and relates to the technical field of biological detection. The application focuses on the biological effect and damage mechanism of neutron radiation, and potential biomarkers under dose gradient are screened. The LD50 and LD100 of mice under neutron radiation are determined as 8 Gy and 12 Gy respectively. The damage degree of radiation-sensitive organs such as spleen and intestinal tract is aggravated with dose gradient. The number of lymphocytes in the blood system is significantly reduced with dose, and can be used as an evaluation index of radiation damage. Cytokines such as IL-6 and IL-10 are significantly up-regulated, which indicates the inflammation and immune regulation mechanism. Ms4a1 is finally screened as a potential key gene, and the expression amount of Ms4a1 changes significantly before and after irradiation, and has very high sensitivity. The method can realize rapid and objective estimation of the neutron radiation dose by detecting the expression amount of Ms4a1 in peripheral blood leukocytes and substituting the dose-effect function, and has clinical transformation value.