Quality control method based on dose-effect color card for anti-inflammatory and analgesia action of qi-stagnation and stomachache granules

Abstract

The invention discloses a quality control method based on a dose-effect color card for anti-inflammatory and analgesia action of qi-stagnation and stomachache granules. According to the quality control method, correlation between the quality and the medicine effect of the qi-stagnation and stomachache granules is evaluated through construction of a fingerprint of the qi-stagnation and stomachache granules and evaluation of the anti-inflammatory and analgesia action of the qi-stagnation and stomachache granules; a dose-effect relationship equation is constructed; the dose-effect color card for the anti-inflammatory and analgesia action of the qi-stagnation and stomachache granules is successfully constructed; and the anti-inflammatory and analgesia action can be intuitively reflected in a form of the 'color card' by detecting the relative peak area of specific components in the qi-stagnation and stomachache granules. The quality control method can be used for evaluating the anti-ulcer action degree and the quality of the qi-stagnation and stomachache granules.

Description

technical field [0001] The invention relates to a drug quality control method, in particular to a quality control method for anti-inflammatory and analgesic granules of Qizhiweitong which uses "color card" software to intuitively reflect the dose-effect relationship. Background technique [0002] The quality control of traditional Chinese medicine compound preparations has always been a difficult and hot issue that plagues the quality monitoring of traditional Chinese medicine preparations and their entry into the international market, and is also an important foundation and key to the modernization of traditional Chinese medicine. my country's quality standards for compound preparations of traditional Chinese medicine have gone through a process from scratch, from simplicity to gradual improvement, and are still being explored. In the 2005 edition of "The Pharmacopoeia of the People's Republic of China", thin-layer chromatography is widely used in the identification of comp...

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Problems solved by technology

At present, a lot of research has been done on the quality control of Qizhi Weitong Granules, and the applicant has carried out patent protection for the quality control method of Qizhi Weitong Granules (full-time multi-wavelength fusion fingerprint quality control method for Qizhi Weitong Granules , Patent No. 201210223306.4), however, the simple quality control method only regulates its chemical composition, and it is unknown whether these chemical compositions are related to their medicinal effects. Based on the efficacy of anti-inflammatory and analgesic drugs, a quality control method for anti-inflammatory and analgesic effects of Qizhi Weitong Granules based on the "dose-effect color card" was established. Quality of Zhiweitong Granules

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