Combination medicine based on active components in Fructus Aurantii, and use thereof

Abstract

The invention relates to a combination medicine based on active components in Fructus Aurantii. The combination medicine comprises, by mass, 9-72% of naringin, 9-72% of neohesperidin, 1-15% of naringenin, 1-15% of hesperetin, and the balance of a medicinal filling auxiliary material. Dose-effect experiments of the main medicine effect components comprising naringin, neohesperidin, naringenin and hesperetin in the traditional Chinese medicine Fructus Aurantii are carried out to carry out composition optimization, and the combination medicine can condition the rising and falling motion of the spleen and the stomach to promote gastrointestinal motility in order to treat gastrointestinal motility disorder, so the combination medicine can be used to treat the gastrointestinal motility disorder disease, and has god exploitation prospect. Compared with present gastric motility promotion medicines, the combination medicine has the advantages of convenient sources of the raw materials, substantial curative effect and no toxic or side effects.

Description

technical field [0001] The invention relates to a combination medicine based on active ingredients in Fructus Fructus Fructus Fructus and its application. Background technique [0002] The accelerated pace of life in modern society, changes in diet structure and many other factors have led to an increasing number of patients with low gastric motility in my country. Decreased gastrointestinal motility often leads to functional dyspepsia, gastroesophageal reflux, and irritable bowel syndrome, which greatly affects people's quality of life, and many people even face the threat of cancer. Gastrointestinal motility is a complex and highly coordinated neuromuscular activity, and it is one of the important physiological functions of the digestive system. Studies have confirmed that the occurrence of gastrointestinal motility disorders is related to each level of the central nervous system (CNS), autonomic nervous system (ANS), enteric myenteric plexus (ENS), gastrointestinal smoot...

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the market that the combined drug based on the active ingredients naringin, neohesperidin, naringenin, and hesperetin in the traditional Chinese medicine Aurantium Fructus is used for the treatment or prevention of gastric motility disorders such as bloating, anorexia, and dyspepsia. Example, therefore, the present invention is the complement and improvement to existing gastrointestinal motility medicine