Combination medicine based on active components in Fructus Aurantii, and use thereof

A technology of active ingredients and drugs, applied in the field of combined drugs based on the active ingredients in Fructus Aurantii, to achieve the effect of promoting gastrointestinal motility, no toxic and side effects, and regulating the ascending and descending movement of the spleen and stomach

Inactive Publication Date: 2016-08-31
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the market that the combined drug based on the active ingredients naringin, neohesperidin, naringenin, and hesperetin in the traditional Chinese medicine Aurantium Fructus is used for the treatment or prevention of gastric motility disorders such as bloating, anorexia, and dyspepsia. Example, therefore, the present invention is the complement and improvement to existing gastrointestinal motility medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A combined drug based on active ingredients in Fructus Fructus Fructus Aurantii, including the following raw materials in mass percentage: naringin 15, neohesperidin 15, naringenin 3, hesperetin 3, and the balance is medicinal filling excipients, medicinal Filling auxiliary materials include: diluents, suspending agents, disintegrants, antioxidants, binders, preservatives, etc.

[0017] Combination medicine based on active ingredients in Fructus Fructus Fructus of the present invention, the dosage form of described combination medicine is tablet, granule, pill, capsule, effervescent tablet, syrup, ointment, soft capsule, emulsion, powder, slow release agent, controlled release agent, targeted preparation or injection, etc.

[0018] The use of the combined medicine based on the active ingredients in Fructus Fructus Fructus of the present invention in the preparation of medicines for treating gastrointestinal motility disorders, specifically, the use of medicines for trea...

Embodiment 2

[0020] A combination medicine based on active ingredients in Fructus Fructus Fructus Aurantii, including the following raw materials in mass percentage: naringin 44, neohesperidin 44, naringenin 5.5, hesperetin 5.5, and the balance is medicinal filling excipients, medicinal Filling auxiliary materials include: diluents, suspending agents, disintegrants, antioxidants, binders, preservatives, etc.

[0021] Combination medicine based on active ingredients in Fructus Fructus Fructus of the present invention, the dosage form of described combination medicine is tablet, granule, pill, capsule, effervescent tablet, syrup, ointment, soft capsule, emulsion, powder, slow release agent, controlled release agent, targeted preparation or injection, etc.

[0022] The use of the combined medicine based on the active ingredients in Fructus Fructus Fructus of the present invention in the preparation of medicines for treating gastrointestinal motility disorders, specifically, the use of medicin...

Embodiment 3

[0024] A combination medicine based on the active ingredients in Fructus Fructus Fructus Aurantii, including the following raw materials in mass percentage: naringin 70, neohesperidin 3, naringenin 13, hesperetin 13, and the balance is medicinal filling excipients, medicinal Filling auxiliary materials include: diluents, suspending agents, disintegrants, antioxidants, binders, preservatives, etc.

[0025] Combination medicine based on active ingredients in Fructus Fructus Fructus of the present invention, the dosage form of described combination medicine is tablet, granule, pill, capsule, effervescent tablet, syrup, ointment, soft capsule, emulsion, powder, slow release agent, controlled release agent, targeted preparation or injection, etc.

[0026] In the preparation of the combined medicine based on the active ingredients in Fructus Aurantii of the present invention, naringin, neohesperidin, naringenin, and hesperetin in mass percentages are added to medicinal fillers, stir...

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PUM

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Abstract

The invention relates to a combination medicine based on active components in Fructus Aurantii. The combination medicine comprises, by mass, 9-72% of naringin, 9-72% of neohesperidin, 1-15% of naringenin, 1-15% of hesperetin, and the balance of a medicinal filling auxiliary material. Dose-effect experiments of the main medicine effect components comprising naringin, neohesperidin, naringenin and hesperetin in the traditional Chinese medicine Fructus Aurantii are carried out to carry out composition optimization, and the combination medicine can condition the rising and falling motion of the spleen and the stomach to promote gastrointestinal motility in order to treat gastrointestinal motility disorder, so the combination medicine can be used to treat the gastrointestinal motility disorder disease, and has god exploitation prospect. Compared with present gastric motility promotion medicines, the combination medicine has the advantages of convenient sources of the raw materials, substantial curative effect and no toxic or side effects.

Description

technical field [0001] The invention relates to a combination medicine based on active ingredients in Fructus Fructus Fructus Fructus and its application. Background technique [0002] The accelerated pace of life in modern society, changes in diet structure and many other factors have led to an increasing number of patients with low gastric motility in my country. Decreased gastrointestinal motility often leads to functional dyspepsia, gastroesophageal reflux, and irritable bowel syndrome, which greatly affects people's quality of life, and many people even face the threat of cancer. Gastrointestinal motility is a complex and highly coordinated neuromuscular activity, and it is one of the important physiological functions of the digestive system. Studies have confirmed that the occurrence of gastrointestinal motility disorders is related to each level of the central nervous system (CNS), autonomic nervous system (ANS), enteric myenteric plexus (ENS), gastrointestinal smoot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/14A61K31/352A61K36/752
CPCA61K31/7048A61K31/352A61K36/752
Inventor 杨武亮胡源祥谭舒舒宋玉鹏陈海芳罗小泉袁金斌
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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