Quality control method of gastrointestinal motility promoting power of qi-stagnation and stomachache granules based on dose-effect color card

Abstract

The invention provides a quality control method of gastrointestinal motility promoting power of qi-stagnation and stomachache granules based on a dose-effect color card. The quality control method comprises the following steps of: establishing a qi-stagnation and stomachache granule fingerprint spectrum and evaluating the acting drug effect of the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules; and evaluating the relevance of the mass of the qi-stagnation and stomachache granules and the drug effect and establishing a dose-effect relational equation, so as to successfully construct an acting dose-effect color card of the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules. Therefore, a gastrointestinal motility promoting power drug effect can be directly reflected in a color card manner through detecting a specific component relative peak area in the qi-stagnation and stomachache granule; the quality control method can be used for evaluating the acting degree and quality of expressing the gastrointestinal motility promoting power of the qi-stagnation and stomachache granules.

Description

technical field [0001] The invention relates to a medicine quality control method, in particular to a quality control method of Qizhiweitong granules for promoting gastrointestinal motility by using "color card" software to intuitively reflect the dose-effect relationship. Background technique [0002] Qi stagnation stomach pain granules are made of 6 traditional Chinese medicines: Bupleurum, Rhizoma Corydalis (roasted), Citrus aurantium, Cyperi cyperi (roasted), Radix Paeoniae Alba, and Radix Glycyrrhizae. Hu can soothe the liver and relieve depression, promote yang and improve qi, Cyperi can promote qi to relieve depression, regulate menstruation and relieve pain. It has a very good therapeutic effect on chest and hypochondrium pain, indigestion, and fullness in the chest and diaphragm. Licorice can relieve flatulence pain and tonify Qi and neutralize. Corydalis is a wonderful product for promoting blood circulation, removing blood stasis, promoting qi and relieving pain...

AI Technical Summary

Problems solved by technology

The emergence of fingerprint technology has brought hope to the quality inspection of traditional Chinese medicine preparations with complex ingredients. However, although the fingerprint detection method is advanced in analysis methods, it is separated from the effective activity and safety activity of the ingredients and cannot express drug efficacy information. Most researchers only use it as a simple quality identification method

[0004] At present, a lot of research has been done on the quality control of Qizhi Weitong Granules, and the applicant has carried out patent protection for the quality control method of Qizhi Weitong Granules (full-time multi-wavelength fusion fingerprint quality control method for Qizhi Weitong Granules , Patent No. 201210223306.4), however, the simple quality control method only regulates its chemical composition, and it is unknown whether these chemical compositions are related to their medicinal effects. Gastrointestinal motility drug effect, established a quality control method based on "dose-effect color card" for Qizhi Weitong Granules to promote gastrointestinal motility, so as to truly control the quality of active ingredients

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