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Natural or synthetic Anti-ulcer Agents relieve and reduce the symptoms of ulcers in the stomach and upper small intestine, systemically and locally, by reducing gastric secretion (proton pump inhibitors), neutralizing hyperacidity (alkalinizing agents), or improving healing and protecting the mucosa (sucralfate). Recurrent gastric and duodenal ulcers caused by Helicobacter pylori infections are treated with antibiotic therapy.
Use of a compound containing a fused heterocyclic ring in the preparation of a medicament for the prevention or treatment of gastric ulcer
The application discloses application of a compound containing a condensed heterocyclic structure in preparation of a medicine for preventing or treating gastric ulcer, and relates to the technical field of medicinal chemistry. It is found through a large amount of screening and verification that the compounds 8018-9590, G642-6944, L861-0480 and E844-1779 can significantly reduce ulcer foci, significantly reduce the degree of hemorrhage, and specifically reduce mucosal edema and other core pathological characteristics of gastric ulcer, and the ulcer inhibition rate reaches 50.00%. The application provides a new compound type for screening of a medicine for treating gastric ulcer, and provides an important candidate for development of a new anti-ulcer medicine.
Owner:GANNAN INST OF INNOVATION & TRANSLATIONAL MEDICINE