Novel hydrophilic-lipophilic gel membrane and preparation method thereof

A gel film and amphiphilic technology, applied in the field of amphiphilic gel materials, can solve problems such as reducing the ability of the skin and the outside world, destroying hair follicles, and affecting the activity of skin cells.

Inactive Publication Date: 2017-06-13
北京乳凝创智生物技术研发中心(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2) The phospholipid layer of the stratum corneum is destroyed, and the water retention capacity is reduced;
[0011] 7) Destroy hair follicles, long-term use will make hair dry, brittle, and easy to lose hair;
[0017] 2. The amount of drug ingredients added cannot satisfy a certain "dose-effect ratio" relationship
[0018] 3. Poor air permeability: The traditional gel film has the problem of poor air permeability, especially oil gel. This poor air permeability is easy to cause skin discomfort, and at the same time makes the skin surface temperature rise sharply, giving people a "stuffy" feeling. At the same time, it can cause severe dehydration in the deep layer of the skin,

Method used

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  • Novel hydrophilic-lipophilic gel membrane and preparation method thereof
  • Novel hydrophilic-lipophilic gel membrane and preparation method thereof
  • Novel hydrophilic-lipophilic gel membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] In this experiment, the amphiphilic gel material was prepared by using styrene-isoprene-styrene block copolymer with a styrene content of 15% as the skeleton material, liquid paraffin as the softener, and hydrogenated rosin glyceride as the tackifier. details as follows:

[0062] Amphiphilic Gel Matrix Formulation:

[0063] component name Styrene and Isoprene Block Copolymer Hydrogenated Rosin Glycerides liquid paraffin hyaluronic acid Sodium polyacrylate Other functional additives ContentWt / % 24.3 21.2 41.5 2 5.4 5.6

[0064] Other functional additives include: inorganic fillers such as calcium carbonate, talcum powder, zinc oxide, etc. to adjust the shape of the amphiphilic gel material.

[0065] The amphiphilic gel matrix preparation method is as follows:

[0066] 1) Add "styrene-isoprene-styrene block copolymer" and liquid paraffin into a reaction kettle with a stirring paddle, heat and stir at a certain temperature until "styre...

Embodiment 2

[0072] In this experiment, a combination of styrene-isoprene-styrene block copolymer and styrene-isoprene diblock copolymer with a styrene content of 15% was used as the skeleton material, and low molecular weight polyisobutylene with a molecular weight of 400 Amphiphilic gel materials were prepared as softeners, hydrogenated rosin glycerides and polyisobutylenes of different molecular weights as tackifiers, as follows:

[0073] Amphiphilic gel matrix material formulation:

[0074] component name Styrene-isoprene-styrene block copolymers and styrene-isoprene diblock copolymers Hydrogenated Rosin Glycerides Medium Molecular Weight Polyisobutylene Polyisobutylene Mn=400 Sodium hyaluronate Sodium carboxymethyl cellulose Sodium polyacrylate Other functional additives ContentWt / % 18.3 12.3 5.9 46.7 2.5 2.7 6.7 4.9

[0075] Other functional additives include: inorganic fillers such as calcium carbonate, talcum powder, zinc oxide, etc. to adj...

Embodiment 3

[0083] In this experiment, the amphiphilic gel material "application aid" was prepared, as follows:

[0084]

[0085] The requirement for the preparation of the "application aid" of the amphiphilic gel material is that the viscosity of the liquid should not be too large or too small, otherwise it will affect the infiltration effect with the skin and the loosening effect on the stratum corneum, making the nutritional ingredients of the drug The skin penetration effect is greatly affected, and at the same time, too sticky will make the skin's comfort worse.

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Abstract

The present invention relates to a novel hydrophilic-lipophilic gel membrane and a preparation method thereof; the dual hydrophilic gel is prepared from a styrene-isoprene-styrene segmented copolymer as a framework material, and also comprises oil and an organic fibrinolytic agent which have the good compatibility with the copolymer, as well as an anti-oxygen, and a hydrophilic/water-absorbing assistant. The membrane has the big characteristic of being capable of being used as a drug carrier under a condition that a surface active agent is not added, a water-soluble drug can be added, a lipophilic drug also can be added, the universality as the drug carrier is expanded, a defect that only the water-soluble drug can be added into a conventional hydrophilic gel, and only the lipophilic drug can be added into a conventional lipophilic gel is solved, each functional component can be kept in a dissolved state and can not be prone to absorb, and a dose-effect ratio relationship (have to meet) of drug components can be met; the novel hydrophilic-lipophilic gel membrane can enhance the transdermal action of the drug components to enable the drug components to fast penetrate through the skins within a short time to be absorbed.

Description

technical field [0001] The invention relates to an amphiphilic gel material prepared with styrene-isoprene-styrene as the skeleton material, which mainly consists of two parts: one part is made of styrene-isoprene-styrene as the skeleton material and The amphiphilic gel contains a certain amount of water-soluble polymer, and the other component is "application aid". It is especially suitable for the preparation of cosmetic facial patches, eye patches, medical and sanitary patches, and health product patches containing or without drugs, or rich in other nutrients, and can also be used to prepare certain medicinal patches. Background technique [0002] At present, in the field of cosmetic face, eye film, health product film and drug film, the matrix materials used are mainly divided into two types: oil gel and hydrogel, but they have the following disadvantages: [0003] 1. The drug carrying capacity and the balance of the nutritional components of the drug are poor. Oil gel...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/81A61K8/67A61K9/70A61K47/32A61K31/355A61K31/375A61L31/06A61L31/14
CPCA61K8/0208A61K8/0212A61K8/676A61K8/678A61K8/8117A61K9/7023A61K31/355A61K31/375A61K47/32A61L31/06A61L31/145A61K2300/00
Inventor 侯玉庆刘彦宏陶几中马丹徐建梅侯天歌
Owner 北京乳凝创智生物技术研发中心(有限合伙)
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