Novel hydrophilic-lipophilic gel membrane and preparation method thereof

Abstract

The present invention relates to a novel hydrophilic-lipophilic gel membrane and a preparation method thereof; the dual hydrophilic gel is prepared from a styrene-isoprene-styrene segmented copolymer as a framework material, and also comprises oil and an organic fibrinolytic agent which have the good compatibility with the copolymer, as well as an anti-oxygen, and a hydrophilic / water-absorbing assistant. The membrane has the big characteristic of being capable of being used as a drug carrier under a condition that a surface active agent is not added, a water-soluble drug can be added, a lipophilic drug also can be added, the universality as the drug carrier is expanded, a defect that only the water-soluble drug can be added into a conventional hydrophilic gel, and only the lipophilic drug can be added into a conventional lipophilic gel is solved, each functional component can be kept in a dissolved state and can not be prone to absorb, and a dose-effect ratio relationship (have to meet) of drug components can be met; the novel hydrophilic-lipophilic gel membrane can enhance the transdermal action of the drug components to enable the drug components to fast penetrate through the skins within a short time to be absorbed.

Description

technical field [0001] The invention relates to an amphiphilic gel material prepared with styrene-isoprene-styrene as the skeleton material, which mainly consists of two parts: one part is made of styrene-isoprene-styrene as the skeleton material and The amphiphilic gel contains a certain amount of water-soluble polymer, and the other component is "application aid". It is especially suitable for the preparation of cosmetic facial patches, eye patches, medical and sanitary patches, and health product patches containing or without drugs, or rich in other nutrients, and can also be used to prepare certain medicinal patches. Background technique [0002] At present, in the field of cosmetic face, eye film, health product film and drug film, the matrix materials used are mainly divided into two types: oil gel and hydrogel, but they have the following disadvantages: [0003] 1. The drug carrying capacity and the balance of the nutritional components of the drug are poor. Oil gel...

AI Technical Summary

Problems solved by technology

[0006] 2) The phospholipid layer of the stratum corneum is destroyed, and the water retention capacity is reduced;

[0011] 7) Destroy hair follicles, long-term use will make hair dry, brittle, and easy to lose hair;

[0017] 2. The amount of drug ingredients added cannot satisfy a certain "dose-effect ratio" relationship

[0018] 3. Poor air permeability: The traditional gel film has the problem of poor air permeability, especially oil gel. This poor air permeability is easy to cause skin discomfort, and at the same time makes the skin surface temperature rise sharply, giving people a "stuffy" feeling. At the same time, it can cause severe dehydration in the deep layer of the skin, and form "sweat retention" on the surface of the skin, causing serious damage to the surface layer of the skin. Although the hydrogel reduces the temperature of the skin surface, shrinks the pores, reduces heat dissipation, and finally reduces skin surface sensitivity. To a certain extent, this solves the discomfort caused by poor air permeability and makes the skin feel comfortable, but to a certain extent, it affects the activity of skin cells, enhances the barrier function of the epidermal stratum corneum, and reduces the material exchange between the skin and the outside world. The ability to affect the transdermal absorption of pharmaceutical ingredients and nutrients

Images