32 results about "Morphine tolerance" patented technology

The invention discloses an anti-opioid peptide, antagonist peptide and application thereof. The anti-opioid peptide is polypeptide formed by the way that one of the following amino acid residue sequences: 1) SEQ ID NO: 1 in the sequence table; 2) SEQ ID NO: 3-5; 3) amino acid residue sequences of SEQ ID NO: 1, SEQ ID NO: 3-5 in the sequence table are subject to substitution, deletion or addition of one to ten amino acid residues to have antagonist morphine anti-harm effect. The antagonist peptide thereof is polypeptide formed by the way that one of the following amino acid residue sequences: 1) SEQ ID NO: 9-11 in the sequence table; 2) amino acid residue sequences of SEQ ID NO: 9-11 in the sequence table is subject to substitution, deletion or addition of one to ten amino acid residues to have effects of enhancing morphine analgesia, reversing morphine tolerance and / or reducing or eliminating abstinence symptom. The anti-opioid peptide and active segment thereof and antagonist peptide can play important role in the medicinal and rehabilitation medicine preparation field and has wide application prospect.

The invention discloses an anti-opioid peptide, an antagonist peptide thereof and use thereof. The anti-opioid peptide has an amino acid residue sequence represented by: 1) an amino acid residue sequence SEQ ID No.1 in a sequence table; 2) an amino acid residue sequence SEQ ID No.3-5; and 3) an amino acid residue sequence obtained by substituting, losing or adding 1 to 10 amino acid residues in the amino acid residue sequence SEQ ID No.1 and the amino acid residue sequence SEQ ID No.3-5 in the sequence table. The anti-opioid peptide is a polypeptide having the antinociptive function of antagonist morphine. The antagonist peptide is has amino acid residue sequence represented by: 1) an amino acid residue sequence SEQ ID No.9-11 in a sequence table; and 2) an amino acid residue sequence obtained by substituting, losing or adding 1 to 10 amino acid residues in the amino acid residue sequence SEQ ID No.9-11 in the sequence table. The antagonist peptide is a polypeptide having the functions of strengthening the pain-relieving effect of morphine, reversing morphine tolerance and / or weakening or eliminating abstinence syndrome. The anti-opioid peptide, the active fragment thereof and the antagonist peptide are expected to play significant roles in the field of medicine and the field of the preparation of medicaments for treating drug addition and have wide application range.

The invention discloses an anti-opioid peptide, as well as an antagonistic peptide and application thereof. The anti-opioid peptide is one of the following amino acid residue sequences: (1) SEQ ID NO:1 in a sequence table and (2) a polypeptide which is obtained by substituting, deleting or adding 1-10 amino acid residues on an amino acid residue sequence of SEQ ID NO:1 in the sequence table and has an antinociceptic effect on antagonistic morphine. The antagonistic peptide is one of the following amino acid residue sequences: (1) SEQ ID NO:5-7 in a sequence table and (2) a polypeptide which is obtained by substituting, deleting or adding 1-10 amino acid residues on an amino acid residue sequence of SEQ ID NO:5-7 in the sequence table and has the effects of enhancing morphine analgesia, reversing morphine tolerance and / or weakening or eliminating abstinence syndromes. The anti-opioid peptide as well as an active segment and the antagonistic peptide thereof play an important role in thefield of preparation of medical and medicament abstinence medicaments, and have wide application prospects.

The invention discloses anti-opioid peptide, and antagonistic peptide and application thereof. The anti-opioid peptide has one of the following amino acid residue sequences: 1) SEQ ID NO:1 in a sequence table; and 2) the amino acid residue sequence shown as the SEQ ID NO:1 in the sequence table is replaced and deleted by 1 to 10 amino acid residues or added with polypeptide with the effect of resisting morphine damages. The antagonistic peptide has one of the following amino acid residue sequences: 1) SEQ ID NO:5-7 in a sequence table; and 2) the amino acid residue sequence shown as the SEQ ID NO:5-7 in the sequence table is replaced and deleted by 1 to 10 amino acid residues or added with polypeptide with the effects of enhancing morphine analgesia, reversing morphine tolerance and / or weakening or eliminating abstinence syndromes. The anti-opioid peptide and an active segment and the antagonistic peptide thereof exert an important effect in the field of preparation of medicinal and drug treatment medicaments and have wide application prospects.

The invention provides an application of endogenic non-coding small RNA miR-873, particularly an application of the miR-873 in drugs for treating or alleviating chronic pain and morphine tolerance. In addition, the endogenic non-coding small RNA miR-873 also can be used in the preparation of preparations for regulating the A20 gene and regulating preparations for the proinflammatory factor TNF Alpha released by the spinal cord under the condition of morphine tolerance. The invention proves that since the miR-873 can regulate the TNF alpha-induced protein-3 (A20) to participate in the development of morphine tolerance, an important foundation is laid for the application of the miR-873 in drugs for treating or alleviating chronic pain and morphine tolerance.