Anti-opioid peptide, antagonistic peptide thereof and use thereof

A technology of anti-opioid peptides and antagonistic peptides, applied in the fields of application, medical preparations containing active ingredients, peptide sources, etc., can solve the problems of acupuncture tolerance and limited efficacy of acupuncture analgesia
CN101323641BInactive Publication Date: 2011-06-01PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2011-06-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an anti-opiate peptide, an antagonistic peptide and an application thereof. The anti-opiate peptide is one of amino-acid residue sequences as follows: 1) SEQ ID NO: 1 in the sequence table; 2) substitution and deletion of one to ten amino-acid residues, or addition of polypeptide which has the functions of antagonism for morphine and antinociception is carried out on the amino-acid residue sequence of SEQ ID NO: 1 in the sequence table. The antagonistic peptide is one of the following amino-acid residue sequences: 1) SEQ ID NO: 5-7 in the sequence table; 2) substitution and deletion of one to ten amino-acid residues, or addition of polypeptide which can enhance the analgesic effect of the morphine, reverse the tolerance of the morphine and / or weaken or eliminate the effect of abstinence symptoms is carried out on the amino-acid residue sequence of SEQ ID NO: 5-7 in the sequence table. The anti-opiate peptide, the active fragment thereof and the antagonistic peptide of the invention can play an important role in the preparation fields of medicine and rehabilitation drugs and have wide application prospect.
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Description

technical field

[0001] The present invention relates to peptides and their coding genes and applications, in particular to an anti-opioid peptide and its antagonistic peptide which can antagonize the antinociceptive effect of morphine, and the antagonistic peptide can enhance morphine analgesia, reverse morphine tolerance and / or Use in drugs that reduce or eliminate the effects of withdrawal symptoms. Background technique

[0002] As we all know, rampant drug trafficking and drug use around the world has become a cancer that endangers society, seriously interfering with orderly economic construction and social stability. In addition, intravenous drug use has also caused a rise in the infection rate of AIDS populations. At present, although the governments of various countries have stepped up efforts to jointly crack down on drug smuggling, drug abuse and drug trafficking activities are still repeatedly banned. One of the important reasons is that the principles of morphine t...

Claims

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