Antagonistic peptide of anti-opioid peptide and application thereof

A technology for anti-opioid peptides and antagonistic peptides, which is applied in the field of anti-opioid peptides and the application fields of the antagonistic peptides, and can solve the problems of acupuncture tolerance and the limited effective rate of acupuncture analgesia, etc.
CN102127151BInactive Publication Date: 2012-07-04PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2012-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an anti-opioid peptide, as well as an antagonistic peptide and application thereof. The anti-opioid peptide is one of the following amino acid residue sequences: (1) SEQ ID NO:1 in a sequence table and (2) a polypeptide which is obtained by substituting, deleting or adding 1-10 amino acid residues on an amino acid residue sequence of SEQ ID NO:1 in the sequence table and has an antinociceptic effect on antagonistic morphine. The antagonistic peptide is one of the following amino acid residue sequences: (1) SEQ ID NO:5-7 in a sequence table and (2) a polypeptide which is obtained by substituting, deleting or adding 1-10 amino acid residues on an amino acid residue sequence of SEQ ID NO:5-7 in the sequence table and has the effects of enhancing morphine analgesia, reversing morphine tolerance and / or weakening or eliminating abstinence syndromes. The anti-opioid peptide as well as an active segment and the antagonistic peptide thereof play an important role in thefield of preparation of medical and medicament abstinence medicaments, and have wide application prospects.
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Description

[0001] This application is a divisional application with the application number 200710100384.4, the filing date is June 11, 2007, and the title of the invention is "anti-opioid peptide and its antagonistic peptide and the application of the antagonistic peptide". technical field

[0002] The present invention relates to peptides and their coding genes and applications, in particular to an anti-opioid peptide and its antagonistic peptide which can antagonize the antinociceptive effect of morphine, and the antagonistic peptide can enhance morphine analgesia, reverse morphine tolerance and / or Use in drugs that reduce or eliminate the effects of withdrawal symptoms. Background technique

[0003] As we all know, rampant drug trafficking and drug use around the world has become a cancer that endangers society, seriously interfering with orderly economic construction and social stability. In addition, intravenous drug use has also caused a rise in the infection rate of AIDS populati...

Claims

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