Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Endogenous long-chain non-coding RNA MRAK049966 and application thereof

A RNAMRAK049966, long-chain non-coding technology, applied in DNA/RNA fragments, recombinant DNA technology, organic active ingredients, etc.

Active Publication Date: 2020-07-10
XIANGYA HOSPITAL CENT SOUTH UNIV
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, it has been reported that lncRNA at the spinal cord level is involved in the regulation of chronic pain, but there is no related research on the specific mechanism of lncRNA involved in the formation of morphine tolerance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Endogenous long-chain non-coding RNA MRAK049966 and application thereof
  • Endogenous long-chain non-coding RNA MRAK049966 and application thereof
  • Endogenous long-chain non-coding RNA MRAK049966 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] Experimental animal grouping and intrathecal administration

[0036] (1) Study and verify the dynamic changes of MRAK049966 in the dorsal horn of the spinal cord during the formation of morphine tolerance

[0037] Select 20 clean male SD rats with successful intrathecal catheterization, and randomly divide them into normal saline group (NS group) and morphine tolerance group (MT group), with 10 rats in each group. Intrathecal injection of 10 μg / 10 μl of morphine was given to rats twice a day (8:00 am, 18:00 pm) for 7 consecutive days, and 10 μl normal saline was injected intrathecally at the same time point in the control group. For the administration procedure, see figure 2 .

[0038] (2) The effect of intervening the expression of MRAK049966 at the spinal cord level on the behavior of chronic morphine-tolerant rats

[0039] ①Effects of overexpression of MRAK049966 at spinal cord level on the behavior of morphine-tolerant rats

[0040]Select 30 clean male SD rats w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses endogenous long-chain non-coding RNA MRAK049966 and application thereof, and specifically relates to application of the long-chain non-coding RNA MRAK049966 to preparation of amedicine for treating or relieving chronic pain. The medicine for treating or relieving chronic pain refers to a medicine for inhibiting morphine tolerance. The long-chain non-coding RNA MRAK049966 is brand-new long-chain non-coding RNA reported for the first time and is proved to be related to morphine tolerance. A new way is provided for treating or relieving chronic pain and relieving or reversing formation of morphine tolerance, and important medical significance is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. The present invention relates to an endogenous long-chain non-coding RNA and its application, in particular to the endogenous long-chain non-coding RNA MRAK049966 and its application in preparing medicine for treating morphine tolerance. Background technique [0002] Morphine, as a classic opioid analgesic drug, is widely used in clinical treatment of acute, chronic, and moderate to severe pain. Tolerance, addiction, hyperalgesia, constipation, respiratory depression and other adverse reactions caused by long-term use of morphine significantly limit the clinical application of morphine. Among them, morphine tolerance (Morphine tolerance, MT) is an important factor limiting the application of morphine. So far, the mechanism of morphine tolerance is not completely clear, and clinically effective prevention and treatment measures are still lacking. Therefore, ascertaining the pathogenesis of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12N15/113A61K31/713A61P25/04
CPCA61K31/713A61P25/04C12N15/113C12N2310/10C12N2310/14C12N2320/30
Inventor 邹望远邓美玲张增利刘畅邢曼玉
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com