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Application of short peptide in preparation of product with morphine tolerance eliminating effect

A morphine tolerance and tolerance technology, applied in the field of biomedicine, can solve the problems of disappearance, reduced analgesic effect, weakened analgesic effect, etc., and achieve the effect of eliminating tolerance

Active Publication Date: 2021-03-19
XUZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main clinical manifestation is the reduction of analgesic effect, which is manifested as the analgesic effect gradually weakens or even disappears after continuous administration of opioids, and it is necessary to increase the dose of opioids to obtain the same analgesic effect

Method used

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  • Application of short peptide in preparation of product with morphine tolerance eliminating effect
  • Application of short peptide in preparation of product with morphine tolerance eliminating effect
  • Application of short peptide in preparation of product with morphine tolerance eliminating effect

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Embodiment Construction

[0016] In order to make the above objects, features and advantages of the present invention more comprehensible, the specific implementation of the present invention will be described in detail below in conjunction with specific examples.

[0017] In the following description, a lot of specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described here, and those skilled in the art can do it without departing from the meaning of the present invention. By analogy, the present invention is therefore not limited to the specific examples disclosed below.

[0018] Second, "one embodiment" or "an embodiment" referred to herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same embodime...

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Abstract

The invention discloses an application of short peptide in the preparation of a product with a morphine tolerance eliminating effect. Researches find that short peptide P10581 can basically and completely turn over an inflammatory pain threshold value induced by carrageenan, and the analgesic effect lasts for more than 12 hours, which indicates that short peptide P10581 has no tolerance to the analgesic effect of mechanical pain, and the tolerance of the analgesic effect of morphine can also be eliminated by the low-dose synthetic short peptide P10581.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of a short peptide in the preparation of a product capable of eliminating morphine tolerance. Background technique [0002] Morphine is an opioid receptor agonist, and its content in opium is 4%-21%, with an average of about 10%. The IUPAC name is 7,8-Didehydro-4,5-epoxy-17-methyl-mor phinan-3,6-diol. The molecular formula is C17H19NO3, and the molecular weight is 285.3. In 1806, the German chemist Zeltina first isolated it from opium and named it morphine after the Greek god of dreams Morpheus. Its derivative, morphine hydrochloride, is a commonly used anesthetic in clinical practice. It has a strong analgesic effect, and its analgesic effect has good selectivity. It is mostly used for severe pain caused by trauma, surgery, burns, etc., and it is also used for myocardial Angina pectoris caused by infarction can also be used as an analgesic, antit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61P25/04
CPCA61K38/10A61P25/04
Inventor 唐琼瑶张赭陈晨唐明希滕月周楠柯少溪董平
Owner XUZHOU MEDICAL UNIV
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