Applications of gelsemine in preparing medicament for treating chronic ache
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A technology of kelezin A and chronic pain, which is applied in the field of application of kelezin A in the preparation of medicines for treating chronic pain, to achieve the effect of improving the therapeutic index, less addictive, and less side effects
Inactive Publication Date: 2008-12-17
FUJIAN MEDICAL UNIV
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There are no literature and patent reports on the anti-chronic pain effect of kelezin A and its possible use
Method used
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Embodiment 1
[0031] Analgesic effect of kelezin A administered subcutaneously on the back of the neck on formalin-induced chronic pain in mice.
[0032]1.1 Drugs and reagents:
[0033] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4
[0034] 1.2 Animals:
[0035] Kunming mice, male, 18-22g, provided by the Experim...
Embodiment 2
[0051] Analgesic effect of kelezin A administered subcutaneously on the plantar side of formalin injection on chronic pain in mice.
[0052] 2.1 Drugs and reagents:
[0053] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4
[0054] 2.2 Animals:
[0055] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at roo...
Embodiment 3
[0070] Analgesic effect of kelezin A administered subcutaneously on the contralateral plantar plantar of formalin on chronic pain in mice.
[0071] 3.1 Drugs and reagents:
[0072] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4
[0073] 3.2 Animals:
[0074] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at room temperature at 25°C under a light-dark cycle of 12 / 12h, free to eat and drink, and used for formal experiments after 3 days of adaptation to the laboratory.
[0075] 3.3 Method:
[0076] 20 mice were ...
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Abstract
The invention discloses the application of gelsemine to the preparation of medicine for treating chronic pains and belongs to the application of gelsemium alkaloid monomer, The analgesic experiments of the gelsemine on chronic pains of animals prove that the gelsemine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsemine is much higher than that of the total alkaloids of gelsemium, the gelsemine possibly has no tolerance, no addiction and little side effect, which indicates that the gelsemine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsemine is possibly different from those of the clinically common opium analgesics or aspirin analgesics, the gelsemine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsemine has bright industrialization prospect.
Description
technical field [0001] The invention relates to the application of gelsemine alkaloid monomer, in particular to the application of gelsemine in the preparation of medicine for treating chronic pain. Background technique [0002] Severe acute and chronic pain plagues tens of millions of patients, among which chronic pain is the most common and the most serious. There are two main types of chronic pain: inflammatory pain and neuropathic (neuropathic) pain. In my country, 20% to 30% of patients have a history of chronic pain, 35% in the United States, and 29% in Canada. The average course of the disease is about 10.7 years. Chronic pain is not only frequent and persistent, but also seriously affects the work and life of patients. Drug analgesia is currently one of the main means of clinically treating pain in patients, among which opioid analgesics such as morphine and antipyretic, analgesic and anti-inflammatory drugs such as aspirin are the most commonly used. At present, ...
Claims
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