Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Applications of gelsemine in preparing medicament for treating chronic ache

A technology of kelezin A and chronic pain, which is applied in the field of application of kelezin A in the preparation of medicines for treating chronic pain, to achieve the effect of improving the therapeutic index, less addictive, and less side effects

Inactive Publication Date: 2008-12-17
FUJIAN MEDICAL UNIV
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature and patent reports on the anti-chronic pain effect of kelezin A and its possible use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of gelsemine in preparing medicament for treating chronic ache
  • Applications of gelsemine in preparing medicament for treating chronic ache
  • Applications of gelsemine in preparing medicament for treating chronic ache

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Analgesic effect of kelezin A administered subcutaneously on the back of the neck on formalin-induced chronic pain in mice.

[0032]1.1 Drugs and reagents:

[0033] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4<pH<7), diluted with physiological saline to the required solution of each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Lysine-pirin freeze-dried powder for injection (9g / bottle, the active ingredient is aspirin), Shanghai Xinya Pharmaceutical Co., Ltd., batch number H31020058. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0034] 1.2 Animals:

[0035] Kunming mice, male, 18-22g, provided by the Experim...

Embodiment 2

[0051] Analgesic effect of kelezin A administered subcutaneously on the plantar side of formalin injection on chronic pain in mice.

[0052] 2.1 Drugs and reagents:

[0053] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4<pH<7), diluted with physiological saline to the required solution of each dosage group.). Morphine hydrochloride injection (10mg / ml), product of Shenyang No. 1 Pharmaceutical Factory, batch number 102090936065021. Indomethacin freeze-dried powder injection, SIGMA company, batch number 115K0689. Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0054] 2.2 Animals:

[0055] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at roo...

Embodiment 3

[0070] Analgesic effect of kelezin A administered subcutaneously on the contralateral plantar plantar of formalin on chronic pain in mice.

[0071] 3.1 Drugs and reagents:

[0072] Kelsin A is obtained by the applicant of the present invention from the natural plant Gelkins extract, separation and purification, with a purity > 98.5% (accurately weighed Kelsin A, dissolved with 1mol / l HCl, diluted with normal saline, adjusted pH with 1mol / l NaOH (4<pH<7), diluted with physiological saline to the required solution of each dosage group.) Formaldehyde solution, Tianjin Beichen Fangzheng Reagent Factory, batch number 20070828.

[0073] 3.2 Animals:

[0074] Kunming mice, male, 18-22g, provided by the Experimental Animal Center of Fujian Medical University. They were raised at room temperature at 25°C under a light-dark cycle of 12 / 12h, free to eat and drink, and used for formal experiments after 3 days of adaptation to the laboratory.

[0075] 3.3 Method:

[0076] 20 mice were ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the application of gelsemine to the preparation of medicine for treating chronic pains and belongs to the application of gelsemium alkaloid monomer, The analgesic experiments of the gelsemine on chronic pains of animals prove that the gelsemine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsemine is much higher than that of the total alkaloids of gelsemium, the gelsemine possibly has no tolerance, no addiction and little side effect, which indicates that the gelsemine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsemine is possibly different from those of the clinically common opium analgesics or aspirin analgesics, the gelsemine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsemine has bright industrialization prospect.

Description

technical field [0001] The invention relates to the application of gelsemine alkaloid monomer, in particular to the application of gelsemine in the preparation of medicine for treating chronic pain. Background technique [0002] Severe acute and chronic pain plagues tens of millions of patients, among which chronic pain is the most common and the most serious. There are two main types of chronic pain: inflammatory pain and neuropathic (neuropathic) pain. In my country, 20% to 30% of patients have a history of chronic pain, 35% in the United States, and 29% in Canada. The average course of the disease is about 10.7 years. Chronic pain is not only frequent and persistent, but also seriously affects the work and life of patients. Drug analgesia is currently one of the main means of clinically treating pain in patients, among which opioid analgesics such as morphine and antipyretic, analgesic and anti-inflammatory drugs such as aspirin are the most commonly used. At present, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P29/00A61P25/04
Inventor 俞昌喜许盈刘浩
Owner FUJIAN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com