Applications of gelsemine in preparing medicament for treating chronic ache

Abstract

The invention discloses the application of gelsemine to the preparation of medicine for treating chronic pains and belongs to the application of gelsemium alkaloid monomer, The analgesic experiments of the gelsemine on chronic pains of animals prove that the gelsemine has potent dose-dependent analgesic effect, the analgesic potency is superior to that of the classical antipyretic-analgesic and anti-inflammatory drugs which are aspirin and indomethacin, the therapeutic index of the gelsemine is much higher than that of the total alkaloids of gelsemium, the gelsemine possibly has no tolerance, no addiction and little side effect, which indicates that the gelsemine has potent and low-toxicity analgesic effect, the mechanism of action of the gelsemine is possibly different from those of the clinically common opium analgesics or aspirin analgesics, the gelsemine and the pharmaceutically acceptable salt thereof have the application of preparing of the medicines for treating chronic pains and have no serious disadvantages of the clinically common analgesics and can be developed into a novel analgesic which has potent analgesic effect in treating chronic pains such as inflammatory pain, neuropathic pain, cancer pain and on the like, has no tolerance and addiction and little side effect, thus the gelsemine has bright industrialization prospect.

Description

technical field

[0001] The invention relates to the application of gelsemine alkaloid monomer, in particular to the application of gelsemine in the preparation of medicine for treating chronic pain. Background technique

[0002] Severe acute and chronic pain plagues tens of millions of patients, among which chronic pain is the most common and the most serious. There are two main types of chronic pain: inflammatory pain and neuropathic (neuropathic) pain. In my country, 20% to 30% of patients have a history of chronic pain, 35% in the United States, and 29% in Canada. The average course of the disease is about 10.7 years. Chronic pain is not only frequent and persistent, but also seriously affects the work and life of patients. Drug analgesia is currently one of the main means of clinically treating pain in patients, among which opioid analgesics such as morphine and antipyretic, analgesic and anti-inflammatory drugs such as aspirin are the most commonly used. At present, ...

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