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A skin wound dressing with antibacterial properties and preparation method thereof

A skin wound and performance technology, applied in the field of biomedical engineering, can solve the problems of lack of inducing tissue regeneration, single function, low compatibility, etc., and achieve the effects of being conducive to re-epithelialization, simple process, and long antibacterial time.

Active Publication Date: 2019-12-10
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a skin wound dressing with antibacterial properties and a preparation method thereof for the existing antibacterial dressings, which have low biocompatibility, long-term use will produce drug resistance, single function, and do not have the function of inducing tissue regeneration.

Method used

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  • A skin wound dressing with antibacterial properties and preparation method thereof
  • A skin wound dressing with antibacterial properties and preparation method thereof

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Effect test

Embodiment 1

[0032] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.1, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

Embodiment 2

[0034] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.25, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

Embodiment 3

[0036] A skin wound dressing with antibacterial properties, the skin wound dressing is a spongy porous membrane structure, using sodium alginate as a matrix, preparing a sodium alginate fiber membrane by a freeze-drying method, and then surface-modifying the Biological antimicrobial peptide Cys-KR12 is prepared by immobilizing on the fiber membrane. Wherein, the weight ratio of the sodium alginate and the antimicrobial peptide Cys-KR12 is 10:0.5, and the molecular weight of the sodium alginate is 2~3×10 5 g / mol.

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Abstract

The invention discloses a skin wound dressing with antibacterial performance and a preparation method thereof, belonging to the technical field of biomedical engineering. The skin wound dressing provided by the present invention has a spongy porous membrane structure. A sodium alginate fiber membrane is prepared by using sodium alginate as a matrix by a freeze-drying method, and then the biological antimicrobial peptide Cys-KR12 is fixed on the fiber membrane by surface modification. Prepared above. The preparation method of the skin wound dressing prepared by the present invention is simple, the source of material is abundant, overcomes the shortcomings such as drug resistance and single function of the existing antibacterial dressing after long-term use, has low immunogenicity, and has good biocompatibility, antibacterial It can promote the healing of wounds and the growth of epithelial cells, which is beneficial to the re-epithelialization of wounds.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a skin wound dressing with antibacterial properties and a preparation method thereof. Background technique [0002] The skin is the barrier between the human body and the external environment, protecting various tissues and organs in the body from external physical, mechanical, chemical and pathogenic microorganisms. When the skin is damaged, if it cannot heal in time, the surface of the wound should be covered with dressing in time. Infection is one of the most common complications in the field of burn wound care, which will lead to a large amount of exudate in the wound, decompose extracellular matrix proteins and various growth factors, hinder epidermal regeneration and wound closure, thereby significantly affecting the recovery process, and even May cause death in burn victims. The therapy of systemic application of antibiotics often does not reach the effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44A61L15/40
CPCA61L15/28A61L15/32A61L15/40A61L15/44A61L2300/232A61L2300/252A61L2300/404C08L5/04C08L89/00
Inventor 卢亢陈锦涛陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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