Oligopeptide capable of relieving analgesic tolerance of morphine in neuropathic pain and application of oligopeptide

A technology for neuropathy and tolerance, applied in the direction of neurological diseases, medical preparations containing active ingredients, peptides, etc., can solve problems such as limiting the clinical application of morphine, increasing pain, and contradictions
CN112851785APending Publication Date: 2021-05-28XUZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XUZHOU MEDICAL UNIV
Publication Date
2021-05-28

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Abstract

The invention discloses an oligopeptide capable of relieving analgesic tolerance of morphine in neuropathic pain and application of the oligopeptide. The oligopeptide is polypeptide with an amino acid sequence as shown in SEQ ID NO: 1, and is named as polypeptide P10581. The synthetic peptide P10581 is a polypeptide with an amino acid sequence as shown in SEQ ID NO: 1, not only has certain analgesic effect, but also does not generate tolerance after being used for multiple times, and a low dosage of P10581 can also improve / eliminate morphine tolerance, so that a new thought is provided for clinical treatment of morphine tolerance and development of new drugs in future.
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Description

technical field

[0001] The invention belongs to the technical field of analgesic drugs, and in particular relates to a short peptide capable of alleviating the analgesic tolerance of morphine in neuropathic pain and its application. Background technique

[0002] Opioids such as morphine are an important choice in clinical pain treatment, but repeated use can lead to physiological tolerance and dependence. Its clinical manifestation is mainly analgesic tolerance, which is manifested in that the analgesic effect gradually weakens or even disappears after continuous administration of opioids, and it is necessary to increase the dose of opioids to obtain the same analgesic effect.

[0003] At present, morphine is one of the most effective clinical drugs for quickly relieving various types of pain, but due to the severe drug tolerance caused by its long-term use, it is often necessary to increase the dose, but at the same time it will lead to increased morphine dose and increased...

Claims

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