1046 results about "Anti oxidative" patented technology

The invention discloses a melogabalin besylate pharmaceutical composition and a preparation method thereof. The invention provides a pharmaceutical composition. The pharmaceutical composition comprises melogabalin besylate, ascorbyl palmitate, a filling agent and a disintegrating agent. According to the pharmaceutical composition provided by the invention, only one antioxidant is added, the antioxidant effect is better than that of a commercial product TARLIGE, the stability of prepared tablets is better, the process production is simple, and the pharmaceutical composition is more suitable for mixing and tabletting the tablets.

The invention relates to the technical fields of medicines, foods, daily chemicals and the like, in particular to two supramolecular eutectic crystals for better solving the application problem of EGCG (epigallocatechin gallate). The preparation method comprises the following steps: firstly, enabling EGCG and betaine to form a supramolecular EGCG betaine eutectic through a supramolecular technology, and synthesizing the supramolecular EGCG betaine eutectic through a supramolecular modification reaction by taking EGCG and betaine as precursors, so that the stability of EGCG can be improved to a certain extent, and meanwhile, the EGCG and the betaine are combined to play a synergistic effect; the supramolecular raw material is formed by enabling supramolecular EGCG betaine eutectic crystals and cyclodextrin to form a supramolecular raw material through host-guest self-assembly, and hydroxypropyl-beta-cyclodextrin and supramolecular EGCG betaine are subjected to host-guest self-assembly to obtain the supramolecular raw material, the supramolecular raw material prepared by the method can solve the stability problem of EGCG, the bioavailability of EGCG is improved, and the bioavailability of EGCG is improved. And meanwhile, the composition has good effects of resisting oxidation, whitening, resisting inflammation, controlling oil and the like, and has a good application prospect.

The invention discloses a compound composition with a multi-target heart protection function as well as a preparation method and application of the compound composition. The composition is composed of a basic functional oil phase, a core antioxidant / anti-inflammatory phase, a myocardial nutrition and regulation phase and a bioavailability promotion phase in a synergistic manner, and is integrated into a composite cardiac oligopeptide and microencapsulated particle key component substance through a specific enzymolysis and microencapsulation embedding process system. The invention aims to solve the technical problems of single target spot, insufficient synergistic effect of all components, low bioavailability of active components and poor stability of the existing heart protection product, and provides a stable and easily-absorbed composite composition which can realize synergistic effect from multiple channels at the same time. Technical effect verification shows that under the condition of equal-dose sample feeding, the composition can remarkably improve the bioavailability of functional components and shows excellent myocardial cell oxidative damage resistance and myocardial ischemia improvement activity in cell and animal models, the effect is remarkably superior to that of independent use or simple physical mixing of all the components, and the composition is suitable for clinical application. And the substantial progress of synergistic interaction is proved. The composition can be used for developing various medicines, health foods and functional foods beneficial to heart health.

The invention discloses a composition with homology of medicine and food and application thereof in relieving physical fatigue, the composition is selected from at least two of ginseng, maca and green tea, and the obtained composition can synergistically regulate oxidation resistance, calcium ion metabolism and energy metabolism, synergistically improve the ATP content and glycogen level of an organism, accelerate removal of lactic acid and urea nitrogen and improve the physical fatigue. And the synergistic effect of the ginseng, the maca and the green tea is better than that of single use of the ginseng, the maca and the green tea. The composition provided by the invention is verified by a standard method of a health-care food function test and evaluation method (2023 edition), and is proved to have a remarkable effect of relieving physical fatigue.

The invention relates to an anti-oxidation composition based on a reverse micelle synergistic technology and a preparation method and application thereof, the anti-oxidation composition comprises a reverse micelle structure and an aqueous solution containing an anti-oxidation active matter, and the reverse micelle structure wraps the aqueous solution containing the anti-oxidation active matter. The reverse micelle structure is used for wrapping the water-soluble antioxidant active matter, oxidation or degradation discoloration of the water-soluble antioxidant active matter is prevented, after the antioxidant active matter such as hydroxytyrosol, ergothioneine and dipotassium glycyrrhizinate is wrapped by the reverse micelle, the stability and the effect are remarkably improved, and after the reverse micelle wrapping, the effect of the antioxidant active matter is improved by 17% or above compared with an aqueous solution before wrapping.

The invention relates to a multi-effect bionic liposome transdermal repair carrier and a preparation method and application thereof.The multi-effect bionic liposome transdermal repair carrier comprises active ingredients and a nano-carrier, and the active ingredients comprise sialic acid, saccharomycetes / rice fermentation product filtrate, arginine / lysine polypeptide and vitamin E in the mass ratio of (1-10): (2-8): (0.1-1): (0.5-4); the nano-carrier is prepared from the following raw materials: phospholipid, an emulsifier, polyhydric alcohol and water. Compared with the prior art, the anti-aging, whitening and moisturizing composition has the advantages of enhancing skin moisturizing and anti-oxidation effects, promoting collagen synthesis and inhibiting tyrosinase to achieve remarkable anti-aging, whitening and moisturizing effects and the like.

The invention discloses an ovarian protection composition containing ergothioneine and a preparation method of the ovarian protection composition, and relates to the technical field of ovarian protection compositions. The ovary protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.1 to 0.5 part of the ergothioneine, 0.05 to 1 part of S-equol, 1 to 5 parts of reducing coenzyme Q10, 1 to 3 parts of vitamin E, 10 to 20 parts of chitosan oligosaccharide, 30 to 50 parts of microcrystalline cellulose, 3 to 8 parts of hydroxypropyl methyl cellulose, 0.5 to 2 parts of silicon dioxide and 0.5 to 2 parts of a stabilizer. By adopting the stabilizer, photooxidation and hydrolysis of sensitive components are inhibited through molecular action, and the long-term stability of the composition in a humid and hot environment is remarkably improved in combination with the physical barrier action of silicon dioxide. Through the antioxidant synergistic effect of the ergothioneine and the vitamin E, the hormone regulation effect of the S-equol and the energy metabolism improvement effect of the coenzyme Q10, a multi-layer ovarian function protection system is constructed, and the health state of ovaries is improved. Through a special process, the tablet can be rapidly disintegrated and slowly released in an intestinal targeted manner, burst release of active ingredients is avoided, and the absorption efficiency is improved.

The invention provides an antioxidant enzyme-containing composition and a preparation method thereof, and relates to the technical field of enteritis treatment. The preparation method comprises the following steps: S1, collecting various component materials for preparing the antioxidant enzyme-containing composition: collecting various raw materials for preparing glucan, fructo-oligosaccharide, galactooligosaccharide, superoxide dismutase, vitamin C, bunge cherry seed powder, cassia seed powder, turmeric, sorbitol, hydroxypropyl methyl cellulose, silicon dioxide and magnesium stearate; according to the invention, a matched powder bagging machine is adopted to realize full-automatic unattended operation to automatically complete the large bag filling and sealing step in the steps S4-S10, vacuumizing is performed firstly and then sealing is performed, and the storage space is compressed by vacuumizing, so that the condition that the bag is expanded and broken by internal air pressure in the transfer and storage process is not easy to cause; in the bag sealing process, the phenomena of high hot melting efficiency and high sealing speed are achieved by adopting a bag strip guiding and rolling hot melting mode.

The invention relates to the technical field of daily chemicals, in particular to a white tomato whitening and repairing composition as well as a preparation method and application thereof. The composition comprises the following components in percentage by mass: 68-85% of jojoba oil, 10-25% of squalane and the balance of white tomato extract, wherein the total percentage is 100%. The white tomatoes are rich in colorless carotenoids (such as phytoene and tetrahydrolycopene), and have excellent antioxidant and whitening capabilities: melanin formation is inhibited, and the colorless carotenoids can inhibit tyrosinase activity, reduce melanin generation and fundamentally whiten the skin. Pigmentation caused by ultraviolet rays can be relieved through the anti-oxidation effect, and the color spots are prevented and faded. The skin color can be brightened after continuous use, so that the skin presents natural luster.

The invention discloses a whitening nano-emulsion and a preparation method thereof, and relates to the technical field of cosmetics and skin care products. The whitening nano-emulsion is prepared from the following components in percentage by weight: 2.0 to 10.0 percent of an emulsifying agent, 4.0 to 10.0 percent of an emollient, 3.0 to 8.0 percent of glycerol, 3.0 to 8.0 percent of butanediol, 0.5 to 3.0 percent of nicotinamide, 1.0 to 3.0 percent of a Soulixian extract, 0.5 to 3.0 percent of ascorbyl tetraisopalmitate, 0.3 to 3.0 percent of hydrogenated lecithin, 0.1 to 2.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 0.1 to 1.0 percent of SymSitive1609, 0.03 to 0.5 percent of a mulberry root extract, 0.03 to 1.0 percent of cerium oxide and the balance of water. The toothpaste is prepared from the following components in percentage by weight: 0.05 to 0.5 percent of tocopheryl acetate, 0.03 to 0.3 percent of stearyl glycyrrhetinic acid ester, 0.01 to 0.1 percent of poly gamma-sodium glutamate, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.2 to 1.0 percent of preservative, 0.01 to 0.1 percent of aromatic and the balance of water, wherein the total The prepared whitening nano-emulsion can solve the problems of excessive addition, difficult absorption and instability of active ingredients of cosmetics, can inhibit DPPH free radical activity, hydroxyl free radical activity and tyrosinase activity through the synergistic effect of all the components, achieves the effects of resisting oxidation, whitening, removing freckles, brightening skin and the like, and does not cause damage to the skin.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses an antioxidant vitamin A ester microcapsule and a preparation method thereof, vitamin A ester is prepared into compact solid powder, external oxygen is effectively isolated, the solid powder is used as a core material, one or two of hydrogenated oil or monoglyceride is / are mixed with phospholipid as a wall material, and the antioxidant vitamin A ester microcapsule is prepared. The core material and the wall material are mixed and then subjected to high-speed dispersion and spray condensation treatment to obtain the vitamin A ester microcapsule, so that the storage stability of the vitamin A ester is greatly improved; meanwhile, the preparation process is simple, and large-scale production is facilitated. The encapsulation efficiency of the antioxidant vitamin A ester microcapsule prepared by the method is more than 90%. And in 35-day accelerated storage test evaluation at 37 DEG C, the retention rate is 80% or above and is obviously higher than the retention rate of the raw materials.

The invention relates to a natural antioxidant for prefabricated vegetables and a preparation method of the natural antioxidant, and belongs to the technical field of food additives. The antioxidant is prepared from rosmarinic acid, carnosic acid, drug-loaded cellulose and double-phase chelating microspheres; the drug-loaded cellulose is prepared by modifying cellulose with quercetin, loading anthocyanin and then wrapping with a trehalose-gamma-polyglutamic acid composite film; the biphase chelating microspheres are phytic acid-citric acid biphase sustained-release microspheres formed by wrapping phytic acid and citric acid with a chitosan and sodium alginate composite film. Through multi-component functional complementation, multi-stage slow release design and physical-chemical synergistic barrier, comprehensive inhibition of the oxidation problem of the prefabricated vegetable is realized, a'free radical scavenging-metal chelating-phase interface stabilization 'triple protection system is constructed, accurate oxidation resistance in different stages of processing, storage and transportation is realized, and the prepared vegetable has good market prospects. The bottlenecks of short action period and single protection dimension of a natural antioxidant are broken through.

The invention belongs to the field of feeds, and discloses a biological feed containing a microbial microcapsule preparation and a preparation method of the biological feed. The biological feed is prepared from the following components in parts by weight: 90 to 93 parts of wall-broken rhodopseudomonas palustris powder, 2 to 3 parts of lysine hydrochloride, 0.1 to 0.5 part of methionine, 0.1 to 0.5 part of threonine, 0.3 to 1 part of arginine, 2 to 3 parts of calcium hydrophosphate, 1 to 2 parts of calcium carbonate, 0.5 to 1.2 parts of an antioxidant additive, 0.3 to 0.8 part of modified nano montmorillonite and 1 to 5 parts of a microbial microcapsule preparation. According to the biological feed, the wall-broken rhodopseudomonas palustris serves as basic nutrition and a main microorganism source of the feed and is matched with the compound probiotics of the microorganism micro-capsule preparation, the intestinal nutrition utilization rate is effectively increased, meanwhile, the antioxidant additive is added, and the problems that a single additive is narrow in function and prone to oxidation are solved; the modified nano montmorillonite is added to solve the problem of antagonism of toxin adsorption and mineral absorption.

The invention provides a fresh-keeping composite solution sprayed before picking fruits in cold-chain logistics transportation and a preparation method of the fresh-keeping composite solution, and relates to the field of fruit fresh keeping. The fresh-keeping composite solution is prepared from the following raw materials in parts by weight: 2.8 to 3.5 parts of schizochytrium limacinum powder, 2.3 to 2.8 parts of salvia officinalis extract, 1.8 to 2.2 parts of brown algae extract, 1.2 to 1.8 parts of banana peel polysaccharide, 0.8 to 1.2 parts of sodium carboxymethyl cellulose, 0.8 to 1.2 parts of tea polyphenol, 0.8 to 1.2 parts of beta-cyclodextrin, 0.8 to 1.2 parts of sodium alginate, 0.8 to 1.2 parts of calcium chloride, 0.4 to 0.6 part of olive oil, 0.1 to 1 part of malic acid and 80 to 90 parts of water. The composite fresh-keeping solution is developed for cold-chain logistics transportation of fruits and is applied before fruit picking, the synergistic effect of multiple natural components is utilized, sterilization and oxidation resistance can be achieved, the growth of microorganisms can be effectively inhibited, the respiration rate of the fruits is reduced, the moisture of the fruits is kept, and the optimal fresh-keeping effect is achieved. The fruit preservative is sprayed before the fruits are picked, so that decay and quality reduction of the fruits in the cold-chain logistics transportation process can be effectively reduced.

The invention relates to the technical field of breeding feed, and discloses an efficient feed additive based on emblic leafflower residue component optimization and a preparation method thereof. Comprising the following components in parts by weight: 30-60 parts of emblic leafflower residues, 10-20 parts of amino acids, 5-15 parts of a vitamin premix, 3-8 parts of a mineral premix, 5-20 parts of probiotics, 0.6-4 parts of cellulase, 0.45-3 parts of pectinase and 0.75-4 parts of amylase. By adding the emblic leafflower residues, the nutrition of the feed additive is enriched, the emblic leafflower residues are rich in cellulose, polyphenol, flavone and other components, have an antioxidant effect, can help animals to remove free radicals in bodies, enhance the antioxidant capacity of the bodies and improve the immunity, meanwhile, the emblic leafflower residues are wide in source and relatively low in cost, and as a feed additive component, the feed cost is reduced; the resource utilization rate and culture benefits are improved.

The invention belongs to the technical field of protein peptide preparation, and particularly relates to mushroom peptide prepared based on Maillard reaction and application of the mushroom peptide to preparation of products with the effects of reducing blood pressure, blood sugar, blood fat and uric acid and antioxidant activity. The mushroom peptide disclosed by the invention has the effects of remarkably reducing blood pressure, blood sugar, blood fat and uric acid and resisting oxidation, and can be used as an auxiliary therapeutic agent or functional food for four high diseases such as hypertension, hyperlipidemia, diabetes mellitus and hyperuricemia and oxidative stress related diseases.

The present invention provides a betahistine antioxidant tablet and a preparation method thereof, the betahistine antioxidant tablet comprises: a first zone comprising anhydrous citric acid, microcrystalline cellulose and hydroxypropyl methylcellulose; the middle buffer area is a sodium alginate aqueous solution coating; a second zone including calcium carbonate, betahistine, and microcrystalline cellulose; the first zone is located at the top of the tablet, the second zone is located at the bottom, and the buffer zone physically isolates the first zone from the second zone. The first zone, the buffer zone and the second zone are designed to form a sandwich structure, oxidation resistance is realized through dual mechanisms of physical isolation and chemical neutralization, and CO2 generated by reaction of food-grade citric acid and calcium carbonate is used for physically replacing oxygen.

The invention relates to the field of functional nutritional seasonings, and particularly discloses an abalone umami peptide prepared from an abalone cooking waste liquid and a preparation method thereof, and the preparation method comprises the following steps: (1) removing solid impurities from the abalone cooking waste liquid, and removing heavy metals by using electrodialysis; (2) adding the material obtained in the step (1) into specific protease accounting for 0.1-1% of the weight of the solid in the material obtained in the step (1), and carrying out an enzymolysis reaction under the conditions that the enzymolysis pH value is 6-7, the reaction temperature is 40-60 DEG C and the reaction time is 0.5-2 hours; and 3) removing impurities by using a nanofiltration membrane, and carrying out spray drying to obtain the abalone umami peptide. According to the abalone flavor peptide prepared by the method, the problem of environmental pollution caused by a large amount of abalone cooking waste liquid is solved, waste is turned into wealth, and a new way of resource utilization of the abalone cooking waste liquid is realized. The ratio gt of the molecular weight of the abalone umami peptide is 1-2KD; the seafood seasoning not only is high in antioxidant biological activity and low in heavy metal content, but also has rich seafood flavor, and can be widely applied to the field of functional nutritional seasonings.

The invention belongs to the technical field of biological medicines, and particularly relates to coumarin hydrazone derivatives with antioxidant activity and application thereof. The chemical structural formula of the coumarin derivative is as shown in formula (I), wherein R is aromatic rings containing different substituent groups. An in-vitro anti-oxidation experiment result shows that most of the derivatives have certain scavenging capacity on free radicals such as DPPH, ABTS, superoxide anions and hydroxyl and have certain reducing capacity. It is worthy of noting that the scavenging effect of the derivatives 5a-5d, 5i-5k, 5m and 5n on superoxide anion free radicals is superior to or equivalent to that of vitamin C. The method for preparing the coumarin hydrazone derivative has the advantages of simplicity in operation, convenience in post-treatment, high product separation yield and the like. The coumarin compound can be used for preparing an antioxidant. # imgabs0 #

The invention discloses a preparation method and processing equipment of herbal composite granules, and relates to the technical field of composite granules. Comprising the following components in parts by weight: 15-20 parts of soybean phospholipid, 10-15 parts of glutamine, 10-15 parts of L-arginine, 5-10 parts of a ginseng extract, 5-10 parts of phytosterol, 5-10 parts of xylooligosaccharide, 5-10 parts of inositol, 5-10 parts of a hawthorn extract, 5-10 parts of a blueberry extract, 5-10 parts of an acerola cherry extract, 0-5 parts of yeast beta glucan, 0-5 parts of a sea-buckthorn extract, 0-5 parts of a tartary buckwheat extract, 0-5 parts of haematococcus pluvialis and the like. The composition is innovative and breakthrough in successful application in the aspects of heart and cerebral vessels and anti-aging, and can regulate intestines, protect liver, reduce blood pressure and regulate blood fat; thrombus is melted, the vascular endothelial function is improved, and arteriosclerosis is prevented; meanwhile, the effects of resisting oxidation, resisting inflammation, resisting aging and enhancing immunity can also be achieved.

The embodiment of the invention discloses a color-stable whitening composition and a skin whitening product. The color-stable whitening composition comprises arbutin, tranexamic acid and a color stabilizer, and the color stabilizer comprises ascorbyl glucoside and ergothioneine. The whitening composition is stable in color and not prone to discoloring, and meanwhile the good skin whitening and anti-oxidation effects can be achieved.

The invention discloses an oral joint protection composition containing ergothioneine and a preparation method thereof, and relates to the technical field of joint protection compositions. The oral joint protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.05 to 5 parts of the ergothioneine, 20 to 50 parts of glucosamine salt, 10 to 30 parts of chondroitin sulfate, 2 to 10 parts of curcumin, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant stabilizer. Through synergistic compatibility of active ingredients such as ergothioneine, curcumin and the like, a multi-dimensional action network of oxidation resistance, inflammation resistance and cartilage metabolism regulation is formed, the inhibition effect on joint inflammation is remarkably improved, and the limitation of a single ingredient is broken through.

The invention discloses an ergothioneine composition with an anti-aging function, and relates to the field of health-care foods, and the composition has the effects of resisting aging and cell molecule oxidation reaction. The composition disclosed by the invention is prepared from the following composition components: ergothioneine (0.162 to 0.185), a wheat germ extract (0.063 to 0.085), coenzyme Q10 (0.042 to 0.063), quercetin (0.35 to 0.55), a turmeric extract (0.032 to 0.054), a black pepper extract (0.003 to 0.006) and aminobutyric acid (0.205 to 0.227). The composition is used for assisting body functions in eliminating lipid, protein, DNA (deoxyribonucleic acid) and the like in cells damaged by oxidative stress in a body. The composition is prepared into equivalent particles by fully and physically stirring and uniformly mixing, is convenient for human body to absorb, and can remarkably improve the antioxidant capacity and delay the aging process after being taken for a long time. The composition not only can effectively resist oxidative stress disoperation, but also can promote cell repair. The raw materials of the composition can be purchased in the market, and the composition is high in production benefit and beneficial to wide application.

The invention provides a biodegradable food preservative film as well as a preparation method and application thereof. The preservative film is a chitosan and polyvinyl alcohol composite film loaded with cinnamon oil microcapsules. The preparation method mainly comprises microcapsule preparation and film preparation. Wherein the microcapsule preparation comprises the following steps: dissolving beta-cyclodextrin, adding cassia oil, and stirring the mixture to form a microcapsule emulsion. And storing the emulsion in a refrigerator overnight. And on the second day, filtering the solution to collect a precipitate, washing and drying to obtain the microcapsule. The film preparation comprises the step of mixing a polyvinyl alcohol solution, a chitosan solution and glycerol according to a fixed proportion. Then, adding cassia oil microcapsules, and uniformly stirring to obtain a film-forming solution; and pouring the film forming liquid into a mold flat plate to prepare a film, thereby obtaining the antibacterial composite film. The tear strength of the prepared film is 21.18 N / mm < 2 > to 43.21 N / mm < 2 >, the elongation at break is 82.60% to 147.56%, and the antioxidant activity is 27.47% to 36.87%; the preservative has an obvious inhibiting effect on staphylococcus aureus and escherichia coli, and can effectively prolong the shelf life of fresh-cut fruits.

The invention provides agar oligosaccharide with an antioxidant function as well as a preparation method and application of the agar oligosaccharide, and belongs to the technical field of degradation of natural polysaccharides. According to the method, a H2O2 / Fe < 2 + > system is adopted to generate hydroxyl free radicals to degrade agar polysaccharide, glycosidic bonds in the agar polysaccharide are oxidized and broken by H2O2 under the catalysis of Fe < 2 + >, so that the agar polysaccharide is degraded into low-molecular fragments, agar oligosaccharide with relatively good antioxidant activity is obtained, then the agar oligosaccharide is compounded with vitamin C, and the antioxidant activity of the agar oligosaccharide is improved. The color of the freeze-dried and redissolved agar oligosaccharide solution can be reduced, and meanwhile, the degraded agar oligosaccharide can be endowed with stronger antioxidant activity. The preparation method provided by the invention is simple in process flow, low in equipment requirement, low in cost and high in agar oligosaccharide yield which can reach 85% or above, and is suitable for industrial large-scale popularization.

The invention belongs to the technical field of nutritional compositions and cosmetics, and particularly relates to an anti-aging composition and application and a product thereof. The composition provided by the invention is composed of L-ergothioneine and alpha-ketoglutaric acid, or L-ergothioneine and alpha-ketoglutaric acid salt, or L-ergothioneine and alpha-ketoglutaric acid salt. Through the synergistic effect of the L-ergothioneine and the alpha-ketoglutaric acid or the alpha-ketoglutarate, the contents of Col I and hydroxyproline in skin tissues can be remarkably increased, the expression of TGF-beta1 is up-regulated and converted, the activity of MMP-1 is inhibited, meanwhile, the malondialdehyde level is reduced to enhance the oxidation resistance, the synthesis of hyaluronic acid is promoted, and the water content of the skin is increased. The composition is simple in component and simple and convenient in preparation process, can be prepared into various products such as cosmetics, health care products or medicines, is used for achieving the effects of resisting aging, moisturizing, resisting inflammation or resisting oxidation, particularly has an excellent improvement effect on skin photoaging induced by ultraviolet rays, and is wide in application prospect.

The invention relates to a high-water-solubility denitroflavin covalent complex as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis and medicinal chemistry. Comprising the following steps: (1) firstly, carrying out bromination reaction on 3-methyl-10-ethyl denitroflavin, so as to obtain 3-methyl-10-(1-bromoethyl) denitroflavin; and (2) coupling the 3-methyl-10-(1-bromoethyl) denitroflavin with vitamin C, so as to obtain the high-water-solubility denitroflavin covalent complex. According to the present invention, the prepared highly water-soluble denitrificin covalent complex has the two-phase solubility of the organic solvent and the water, such that the water solubility of the 3-methyl-10-ethyl-denitrificin is substantially enhanced, and the application range of the denitrificin is expanded. And meanwhile, the denitrified flavin covalent compound also has good antioxidant activity, and the antioxidant duration can be prolonged.

The invention relates to the technical field of feed additives, and discloses a feed combination agent for improving the reproductive performance of sows by using 25-OH-VD3 and a preparation method thereof, and the preparation method comprises the following steps: taking an innovative product 25-OH-VD3 as a main raw material, and optimally combining other micronutrients, immune substances, metabolism promoting substances and the like for cooperative utilization to prepare the combination agent. The innovative 25-OH-VD3 not only serves as a golden partner for calcium and phosphorus metabolism of an organism, but also plays a wide immune regulation function, improves the reproductive function of pigs together and strengthens an optimized feed combination method and composition of the main effect of the 25-OH-VD3 at the same time, and other vitamins, trace elements, targeted active substances and other optimized combinations are preferably selected. The feed mainly solves the technical problem of integration of health and reproductive disorder of modern pig raising, and has the effects of remarkably enhancing the immunity of the sows, resisting oxidation and stress and systematically improving the reproductive performance of the sows.

The invention relates to an exosome fusion liver targeting liposome drug delivery system as well as a preparation method and application thereof, and belongs to the field of high polymer material science and pharmaceutical preparations. The invention discloses an exosome-fused liver-targeted liposome drug delivery system, which combines high-concentration PEG8000 and Nycodenz in a breakthrough manner, synergistically improves the fusion efficiency of exosome and liposome, and forms bionic vesicles with uniform size and high drug loading capacity. The exosome not only can exert the anti-inflammatory and anti-oxidation characteristics, but also plays a role in resisting a severe gastrointestinal environment and crossing a biological barrier. In addition, liposome is modified by cholic acid derivatives through EDC / NHS mediated amidation reaction, precise targeting of the liver is achieved, and the liposome is fully accumulated in the liver. The effects synergistically realize the treatment of type II diabetes and non-alcoholic steatohepatitis.