2324 results about "Anti oxidative" patented technology

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and / or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO2 or CO2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e.g. irritated skin, or to support medical therapy of skin with atopic dermatitis symptoms, atopic dermatitis, psoriasis or related diseases (e.g. accompanied by distorted barrier function of the skin and microbial load). The compositions of the invention can be used for dermo-cosmetic products but also for pharmaceutical / -medical products, depending on the composition and the additional actives incorporated (cosmetic actives or drugs). The invention is based on the synergistic effect of metallic particles, in particular silver particles (such as microsilver, nanosilver) and lipid particles (lipid nanoparticles or lipid microparticles). As alternatives to silver particles, other metallic particles (e.g. zinc, copper) or nanocrystalline actives can be incorporated (e.g. replacing the anti-oxidative silver by anti-oxidative nanocrystals of plant molecules such as hesperitin). This leads to combinations of lipid particles with nanocrystals for dermal use.

The invention provides a high-abrasion Ti(C, N) based metal ceramic tool and a preparation thereof. The Ti(C, N) based metal ceramic tool uses Ni and Co as a binder phase, is added with at least one carbonitride of Ti(Cx, N1-x) or (TiC)x plus (TiN)1-x as a basic batch, and consists of at least one composition of WC, Mo2C, Co, Ni, ZrC, Cr3C2, VC, TaC and NbC, and the balance being Ti(Cx, N1-x) or (TiC)x plus (TiN)1-x, wherein, an X value for adding the carbonitride of the Ti(C, N) based metal ceramic tool is as follows: X is less than or equal to 0.5 and more than or equal to 0.4, or the X is more than 0.5 and less than or equal to 0.7. The Ti(C, N) based metal ceramic tool is prepared according to the content of nitrogen by nitrogen pressure sintering or vacuum sintering combined with hot isostatic pressing treatment, thereby preventing nitrogen from escaping during the process of sintering high-nitrogen alloy, so that the high-nitrogen-carbon ratio in matrix and material hardness can be reliably guaranteed, and anti-oxidative abrasion property and anti-diffusive abrasion property of the material can be obviously increased through adding slight ZrC, Cr3C2, VC and other carbides into the basic batch; meanwhile, compactability and buckling strength of a low-nitrogen alloy structure can be obviously improved through optimally distributing each composition and content. The Ti(C, N) based metal ceramic tool is widely suitable for high-speed cutting tools of medium-low carbon steel and low alloy steel.

An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E. Also preferably dissolved in the adhesive are glycerine and a polydiorganosiloxane adhesion-adjusting agent. Optionally dissolved in the adhesive is also one or more members selected from the group consisting of moisturizing agents, skin collagen synthesis promoting agents and exfoliating agents. When applied to a wrinkled skin area the composition acts to diminish fine wrinkles and improves the overall thickness, elasticity, firmness and smoothness of the skin. The modified adhesive properties of the patch are sufficient to maintain the patch in place on the skin for the recommended treatment period while allowing the patch to be readily removed without causing skin irritation or leaving adhesive residue on the skin.

To maximize and maintain the antioxidant or pro-oxidant state for foods, beverages, personal care products, cosmetics, nutritional supplements, reagents, analytical standards, medical device formulations, pharmaceutical preparations or drags, the present invention discloses methods and devices to control redox equilibrium of such preparations throughout the processing steps and storage prior to, or at, the time of administration or use. The preparations (solid or liquid form) can then be stored in a redox-controlled container, package or applicator as described in the specification. Foods, beverages, personal care products, cosmetics, nutritional supplements, reagents, analytical standards, medical device formulations, pharmaceutical preparations and drugs stored in reactive oxidation states can be activated and stabilized by electrical voltages applied with a small battery and electrodes designed into the applicator, container or package.

The invention discloses an anti-oxidative color masterbatch. The anti-oxidative color masterbatch comprises the following raw materials in percentage by weight: 10-70% of pigment, 1-22% of antioxidant composition, 5-30% of dispersion and lubrication agent, 20-60% of carrier resin and 0-15% of filler, wherein the antioxidant composition comprises a hindered phenolic antioxidant and one or more of a phosphite antioxidant, a thio antioxidant and a light stabilizer. The invention further discloses a preparation method and application of the anti-oxidative color masterbatch. The anti-oxidative color masterbatch disclosed by the invention has the advantages of good uniformity, good stability, good processability, good mobility and good heat and weather resistance; the preparation method of the anti-oxidative color masterbatch has the advantages of simplicity, no pollution to factory buildings and no pollution to operating personnel; and during use, the dispersion is easy, the adding dosage is small, the service lives of plastic products can be prolonged remarkably, the brightness of colors of the plastic products can be increased, and the fading time of the plastic products can be delayed.

The field of the present invention comprises pharmaceuticals and pharmaceutical treatments, including, for example, (i) compounds and formulations which cause the augmentation of anti-cancer activity (i.e., by enhancement of the lethal cytotoxic action in stimulatory [inducing oxidative stress] and / or depletive [decreasing anti-oxidative capacity] manner) of chemotherapeutic agents, in a selective manner; (ii) methods of administering said anti-cancer augmentation compounds and formulations; (iii) delivery devices containing said anti-cancer augmentation compounds and formulations; and (iv) methods of using said anti-cancer augmentation compounds, formulations, and devices to treat subjects in need thereof.

The invention is directed to therapeutic antioxidant compositions which are enhanced by the stabilized atomic hydrogen; one of the most potent antioxidants. Such products can be used for prophylactic and therapeutic purposes in treatment of cancer, diabetes, autoimmune diseases, neurodegenerative diseases, cardiovascular diseases, skin diseases etc. The products described can be used independently or in combination with other drugs and treatment modalities. The products can also be used as dietetic products to aid in desired weigh loss. The described products can also be used to prevent oxidative and free radical damage to food and oxidation-prone industrial products. The invention also describes the methods to produce and stabilize atomic hydrogen and prepare and use such stabilized / encaged atomic hydrogen enhanced antioxidant compositions.

The invented healthy edible salt is prepared by mixing with sodium chloride, various amino acid, peptide substance, vitamin B family, polysaccharide, or chitin, antioxidant, nucleic acid seasoning, potassium chloride, calcium salt, magnesium salt, selenium salt, and potassium iodide. It can effectively prevent various diseases, also can prevent osteoporosis, cancer, diabetes, dysinsulinosis, lithiasis, coronary heart disease, senile dementia, bark farus etc. it also possesses the functions of antisenility, antifatigue, antidepression, improving immune power, promoting growth etc.

The invention discloses red date potato chips. The red date potato chips are characterized by being prepared from the following raw materials in parts by weight: 100 parts of smashed potato, 20 parts of wheat germ powder, 5 parts of xylitol, 5 parts of red date meat paste, 5 parts of red bean paste, 5 parts of pumpkin, 1 part of cushaw flower, 2 parts of eggplant, 2 parts of Chinese broccoli, 0.2 part of lotus leaf powder, 2 parts of boletus edulis, 2 parts of green red pepper, 0.2 part of semen cassiae powder, 2 parts of ginger, 1.0 part of baking soda, 2 parts of salt, 10 parts of white sugar, 0.5 part of monosodium glutamate and a proper amount of water. The red date potato chips are prepared from the wheat germ powder, the red date meat paste, the red bean paste, the pumpkins, the cushaw flowers, the eggplants, the Chinese broccoli, the boletus edulis and the green red peppers, so that the red date potato chips contain rich vitamins, and are anti-oxidative and good to health, and the immune function of a human body can be improved; the lotus leaf powder and the ginger have the effects of invigorating the stomach and reducing blood pressure, so that the potato chips have a health care function; and the formula is in line with the needs of the human body, so that the physical health is maintained when a person enjoys the potato chips, and the potato chips belong to delicious food.

The invention provides a medical or health-care compound and a preparation method. The compound contains at least one natural anti-bacterial agent which is separated for plants and is the soluble salt or ester formed through the extraction of the non-soluble anti-bacterial substance from plants. Further, the compound of the invention can also contain inflammation-diminishing, detumescence and anti-oxidation ingredients, as well as the preparation type auxiliary substances, Chinese medicine padding agent, etc, which are produced into a series of medicines or health-care medicines which restrain the anaerobic bacteria and effectively prevent the oxidation or aging of the human body cells. The compound of the invention can be produced into various forms, not only confined in the liquid form (for example the orally taken liquid), but also including spraying agent, liquid spraying agent, pills( e.g. buccal tablets), capsules, toothpaste, mouth clearing, etc. Moreover, the invention can be used for the health care for mouth, heart, gastrointestinal tract and joint or the treatment of the related diseases.

The invention discloses a natural beta- carotene microcapsule and process for preparation, wherein the microcapsule comprises the following raw materials (by weight portion), natural beta-carotene oil solution 10-50, modified starch 20-32, beta cyclodextrin 5-18, maltodextrin 5-15, oil phase emulsifying agent 0.8-2, aqueous phase emulsifying agent 0.7-1.5, dispersing agent 5-15, preservative agent 0.5-1, anti-oxidizing agent 0.1-0.5.

The present invention belongs to the field of medicine, and particularly relates to a novel curcumin pharmaceutical preparation, which comprises a solid dispersion, a micellar preparation, SMEDDS and a nanometer emulsion. According to the present invention, by increasing the solubility and the bioavailability of curcumin, the curcumin pharmaceutical preparation can effectively utilize the pharmacological effects of anti-oxidation, anti-inflammation, anti-cancer, apoptosis induction, antiangiogenesis, neuroprotection, anti-microorganism, liver and kidney protection, vascular formation inhibition, myocardial infarction prevention, blood glucose lowering, anti-rheumatism and the like of the curcumin.

The invention discloses a composition containing a haematococcus extract and a collagen peptide. The composition is prepared from the following components in part by weight: 1 to 20 parts of haematococcus pluvialis extract, 1 to 10 parts of collagen peptide and 1 to 90 parts of safflower seed oil. The invention also discloses a preparation method for the composition. Natural astaxanthin in the haematococcus pluvialis extract has the ultrahigh oxidation resistance, ensures the normal metabolism of skin, inhibits the generation of melanin and enhances the effect of collagen; the absorption rate of the collagen peptide is between 95 and 100 percent; the collagen peptide can improve the metabolism of skin cells effectively, and can be utilized by the skin cells more easily, so that the activity of the collagen in the skin is enhanced, and the aims of preserving moisture, resisting wrinkles and nourishing the skin are fulfilled; and due to the addition of the safflower seed oil, the composition contains linoleic acid with high content and vitamin E and can prevent the oxidative deterioration of the astaxanthin, an antioxidant is not needed to be added, and the quality guarantee period can be prolonged by one time.

The invention discloses a beverage capable of maintaining beauty and nourishing the skin and a preparing method of the beverage. The beverage capable of maintaining beauty and nourishing the skin is prepared from collagen tripeptide, chitosan oligosaccharide, gamma-aminobutyric acid, fish collagen peptide and skipjack elastin peptide. The beverage achieves great effects of adjusting and repairingthe skin of the human body in combination with multiple collagen nutrients, vitamin C and nutrient substances resistant to sugar and oxidation required for the human body.

The invention discloses a preparation method for a chlorella anti-oxidative peptide. The preparation method is as follows: by taking chlorella as material, carrying out wall-breaking treatment on the chlorella to obtain soluble protein by utilizing a dilute alkali swelling-combined ultrasonic-wave process; and hydrolyzing the chlorella protein by a biological enzyme method to obtain the chlorella anti-oxidative peptide with remarkable anti-oxidative effect. The invention further discloses a treatment process combining ultralow temperature treatment, high pressure treatment with dilute alkali swelling and ultrasonic waves, which can improve yield of the water-soluble protein and can further improve anti-oxidative ability of hydrolysate. A product obtained by virtue of the preparation method disclosed by the invention is high in purity and strong in anti-oxidative activity.

The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.

The invention provides an oxidation resisting polypeptide and a preparation method thereof. The method takes sharkskin collagen as the raw material. By means of enzymolysis of acidic protease, separation and purification, a specific oxidation resisting polypeptide can be obtained, with a molecular weight of 902Da and a complete amino acid sequence as Gly-Thr-Met-Gly-Ala-Val-Gly-Pro-Arg-Gly. The oxidation resisting polypeptide of the invention eliminates the defects of natural antioxidants and relieves the public from their anxiety about synthetic antioxidant, thus establishing the theoretical foundation for developing oxidation resisting polypeptide based on food sources and exploring the wide application of the oxidation resisting polypeptide in food and medical science.

The invention belongs to the field of cosmetics, and specifically relates to a cosmetic containing a fullerene derivative. The composition contains fullerene, polypeptide, hyaluronic acid, vitamin and collagen. The fullerene added to the cosmetic composition can strengthen oxidation resistance and clear free radicals at the same time, so that the cosmetic can resist senescence and recover skin vitality after being used. By using the several components together, water can be effectively supplemented, the skin can be moistened for a long time, and a whitening effect is achieved at the same time.

A nutritional supplement, prepared food product, or direct food additive for ingestion by mammals, and methods for preparing such products, are provided. Products of the invention comprise an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytosterols. The fat-based composition includes greater than 25% and less than 75% by weight of one or more triglyceride-based edible oil or fat, and greater than 25% and less than 75% by weight of one or more non-esterified phytosterols. The fat-based composition, when exposed to air, contains a reduced amount of oxidative by-products compared to a similar fat-based composition lacking non-esterified phytosterols. Also provided are methods for reducing plasma cholesterol in mammals, and methods for protecting plasma lipoproteins and cholesterol from oxidation by ingestion of products of the invention.

The invention provides yak bone protein peptide with DPP-IV inhibitory activity and a preparation method thereof. The yak bone protein peptide provided by the invention is optimally prepared from the enzymolysis products by conducting multiple-step enzymolysis by multilevel compound protease on the yak bone protein prepared from yak bone, and the compound protease contains alkali protease, neutral proteinase, trypsin and flavourzyme. The yak bone protein peptide provided by the invention has excellent DPP-IV inhibition and antioxidation functions, and can be used as a DPP-IV inhibitor and antioxidation raw material to be applied to special foods and nutritional foods.

The invention relates to a new pharmacotherapeutical strategy, to an anti-stress, anti-impairment and anti-aging drug and to a process for its manufacturing. The drug has an etio-pathogenic and homeostatic action, was preclinically tested and clinically checked up in geriatric, neurologic, psychiatric and stress-dependent pathology. The drug achieves a synergistic biological, neurometabolic and cell-trophic composition, being elaborated by the association of the following active principles: a) against oxidative and catabolic stress; methionine with aminoethanol phenoxyacetates and / or aminoethyl phenoxyacetamides; b) against anabolic stress; hydroxopyrimidine carboxylates and / or oxopyrrolidine acetamides with potassium, zinc and lithium; c) vasodilative and normolipidemic; nicotinic, alcohol and / or acid, or its derivatives, with magnesium and iodine; d) energo-active and e) anti-toxic; aspartate; fructose; vitamin B1; vitamin B6; monoacid phosphate and sulfate. The process for manufacturing the drug stipulates; a) pharmaceutical preparation in two complementary types of capsules or coated tablets, gastrosoluble and enterosoluble, the last being enteric coated; b) prolonged-release of vasodilator from the enterosoluble unit.

The invention relates to a preparation method for an antioxidant fish oil microcapsule. The method comprises the following steps: mixing and homogenizing Arabic gum and fish oil to produce an Arabic gum-fish oil emulsion, then dropping in an acetic acid solution of chitosan, regulating the concentration and the pH value, reacting to generate a complex condensation product at the temperature of 20-25 DEG C, freeze drying the complex condensation product finally to obtain the antioxidant fish oil microcapsule which takes chitosan and Arabic gum as a wall materials. The invention has the advantages of simple operation, stable preparation technology and the like. The source of chitosan and Arabic gum is wide and the two materials are easy to take. According to the invention, chitosan and Arabic gum are taken as the wall materials for combining the advantages to prepare the fish oil microcapsule by a complex coacervation method, the prepared fish oil microcapsule has the advantages of smooth surface and uniform particle size and effectively reaches the antioxidation effect of the fish oil, the method for preparing the antioxidant fish oil microcapsule has good research and exploitationapplication prospect in food industry and medical field.

Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.

The invention relates to a skin care composition with moisturizing and anti-oxidation effects, and applications and a preparation method thereof. The composition comprises the following components inparts by weight: 0.01 to 1.0 part by weight of allantoin; 0.01 to 0.5 part by weight of wrapped retinol; 0.1 to 1.0 part by weight of ceratonia siliqua seed extract; 1 to 5 parts by weight of cladosiphon novae-caledoniae extract; 0.01 to 1.0 part by weight of a plant sensitizing agent; 0.01 to 1.0 part by weight of a high-efficiency humectant; 0.01 to 1.0 part by weight of phytoestrogen; 0.01 to 2.0 parts by weight of lactococcus ferment lysate; 0.01 to 2.0 parts by weight of glycosaminoglycan; 0.01 to 0.5 part by weight of carnosine; and 0.1 to 3.0 parts by weight of anti-bloodshot factors. The method utilizes different medicinal mechanisms of different components, and fully exerts the synergistic effect among the components, so that the obtained composition can resist free radicals, inhibit skin inflammation, improve skin immunity and self-repair ability of skin cells, promote collagen and elastic fiber growth, and make skin moisturized, firm, bright and beautiful.

The invention discloses a treatment method for antibacterial and anti-ultraviolet cotton fabrics. The treatment method comprises the following steps: step 1, soaking the cotton fabrics with a nonionic surfactant; step 2, modifying the cotton fabrics with chitosan quaternary ammonium salt; step 3, dipping the cotton fabrics with antibacterial finishing liquid prepared by mixing 5-15 parts of a natural antibacterial agent composed of extracts of grape seeds, persimmon leaves, ginkgo leaves and licorice roots, 0.3-1 part of polyoxyethylene-40 hydrogenated castor oil and 1000 parts of water; step 4, soaking the cotton fabrics in a mixed aqueous solution containing 0.001-0.005mol / L of silver nitrate or silver sulfate or silver acetate and 1-3 g / L of soluble starch or hydroxyethyl cellulose to prepare the nano-silver attached antibacterial cotton fabrics. The prepared cotton fabrics not only have good antibacterial performance and anti-ultraviolet performance, but also have performance of resisting oxidation and scavenging free radicals, and have improved anti-wrinkle performance and good washing durability.

The invention discloses a method for degrading enteromorpha prolifera polysaccharides by an enzymic method. The method disclosed by the invention is characterized by comprising the following steps: preparing a polysaccharide solution with concentration of 1-20mg / mL from crude enteromorpha prolifera polysaccharides or enteromorpha prolifera polysaccharides; then with glucoamylase as hydrolase, reacting for 1-5 hours under the conditions that the pH value is 3.5-5.5 and the temperature is 40-60 DEG C, thus obtaining a solution of polysaccharides degraded through enzymolysis for the first time; boiling the solution of polysaccharides degraded through enzymolysis for the first time for 4-6 minutes and then centrifuging the solution of polysaccharides degraded through enzymolysis for the first time to remove glucoamylase, thus obtaining supernatant containing enteromorpha prolifera polysaccharides degraded through enzymolysis for the first time; and dialyzing and freeze-drying the supernatant, thus obtaining powdery enteromorpha prolifera polysaccharides (with molecular weight range of 7.2-122kDa) degraded through enzymolysis. The method has the characteristics of high hydrolysis efficiency and high in vitro antioxidative activities of obtained polysaccharides.

The invention relates to a preparation method of antioxidant peptide and aims to provide a preparation method of pumpkin seed antioxidant peptide with wide sources of raw materials, low cost and high antioxidant activity. The preparation method comprises the following steps of: (1) preparing pumpkin seed isolated protein solution, namely preparing pumpkin seed isolated protein from defatted pumpkin seed powder serving as a raw material by an alkali-solution and acid-isolation method and preparing the pumpkin seed isolated protein solution by adding water; (2) performing enzymolysis, namely heating the pumpkin seed isolated protein solution in a boiling water bath to denature the protein, adjusting the pH value to be 2.5 to 3.5 after cooling, and adding protease with the dose of 5,000 to 8,000 U / g to hydrolyze in a water bath at the temperature of between 45 and 55 DEG C for 2 to 6 hours; and (3) after deactivating enzyme and performing centrifugation, allowing zymolytic solution to pass through ultrafiltration enrichment active peptide, concentrating, freezing and drying to obtain the pumpkin seed antioxidant peptide. The antioxidant peptide has remarkable reducing capacity, high free radical-removing capacity, wide application, remarkable social and economic benefits, optimal enzymolysis process conditions and wide sources of the raw material, increases utilization ratio of the raw material, and utilizes waste materials.