Injectable bone-repairing hydrogel containing exosomes of human umbilical cord mesenchymal stem cells and preparation method of injectable bone-repairing hydrogel

A mesenchymal stem cell and composite hydrogel technology, applied in the field of injectable bone repair hydrogel containing human umbilical cord mesenchymal stem cell exosomes and its preparation, to achieve convenient operation, efficient treatment method, good exosome slowing The effect of release function
CN112206356AInactive Publication Date: 2021-01-12温宁
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
温宁
Publication Date
2021-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to injectable bone-repairing hydrogel containing exosomes of human umbilical cord mesenchymal stem cells and a preparation method of the injectable bone-repairing hydrogel, and belongs to the technical field of biomedical engineering. The hydrogel material contains exosomes of human umbilical cord mesenchymal stem cells, nano-hydroxyapatite, a hyaluronic acid-adipic dihydrazide derivative and an alginic acid derivative with an aldehyde group on a main chain. The preparation method comprises the steps of separation of human umbilical cord mesenchymal cells, extraction of exosomes, preparation of nano-hydroxyapatite, preparation of a hyaluronic acid-adipic dihydrazide derivative, preparation of composite hydrogel and the like. The injectable bone-repairing hydrogel provides a new repair method for a bone defect treatment and has a wide application prospect and an ideal repair effect.
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Description

technical field

[0001] The invention relates to the technical field of biomedical engineering, in particular to an injectable bone repair hydrogel containing human umbilical cord mesenchymal stem cell exosomes and a preparation method thereof. Background technique

[0002] Bone defect repair is a hot topic in the field of orthopedics. Clinically, even for common fractures, about 2%-10% of fractures may progress to nonunion due to poor bone regeneration. Orthopedic clinicians often encounter problems such as bone defects caused by fractures, bone infections, and bone tumor resections. In addition, obesity, diabetes, etc. lead to an increase in musculoskeletal diseases and a decrease in bone regeneration. Elderly patients with osteoporosis have a higher risk of fracture and insufficient bone regeneration capacity. Therefore, how to promote bone regeneration remains a major challenge for clinicians.

[0003] Bone tissue engineering technology based on mesenchymal stem cells ...

Claims

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