Injectable bone cement containing strontium and preparation method of bone cement

A bone cement and strontium source technology, applied in the field of strontium-containing injectable bone cement and its preparation, can solve the problems of non-absorption and degradation, weak integration with bone, and no osteogenesis

Active Publication Date: 2014-11-19
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PMMA bone cement can be injection molded and made into any shape, and has high mechanical strength, but at the same time, PMMA bone cement still has some limitations [Belkoff, S.M et al...Temperature measurement during polymerization of polymethylmethacrylate used for vertebroplasty.Spine.28: 1555-1559], such as the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body. Reaction may cause neurological impairment effect of adjunctive methylmethacrylate on failures of fixation and function in patients with intertrochanteric fractures and osteoporosis.J.Bone Joint Surg(am).1985,67(7):1094], etc.

Method used

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  • Injectable bone cement containing strontium and preparation method of bone cement
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  • Injectable bone cement containing strontium and preparation method of bone cement

Examples

Experimental program
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Effect test

Embodiment 1

[0035] (1) The preparation method of strontium hydrogen phosphate powder: configure 200ml of 0.5mol / L strontium nitrate solution, and add 0.6mol urea into it and stir to dissolve to obtain A solution; configure 200ml of 0.5mol / L diammonium hydrogenphosphate solution, Obtain B solution; Pour B solution into A solution, stir and mix, the solution becomes a turbid suspension, add concentrated nitric acid (65-68%), adjust the pH value to 2, the solution becomes clear; put the clear solution into In a water bath at 80°C, react at a constant temperature for 4 hours, pour out the supernatant, wash repeatedly, filter the white precipitate, dry and grind at a constant temperature in an oven at 100°C to obtain a powder product. The prepared product was characterized by XRD, as attached figure 1 As shown, the absorption peak corresponds well to the standard peak (PDF33-1335), and it can be determined that the prepared product is strontium hydrogen phosphate.

[0036] (2) The preparation...

Embodiment 2

[0039](1) The preparation method of strontium hydrogen phosphate powder: configure 200ml of 0.3mol / L strontium nitrate solution, add 0.3mol urea into it and stir to dissolve to obtain A solution; configure 200ml of 0.3mol / L diammonium hydrogenphosphate solution, Obtain B solution; Pour B solution into A solution, stir and mix, the solution becomes a turbid suspension, add concentrated nitric acid (65-68%), adjust the pH value to 2, the solution becomes clear; put the clear solution into In a water bath at 90°C, react at a constant temperature for 3 hours, pour out the supernatant, wash repeatedly, filter the white precipitate with suction, dry and grind at a constant temperature in an oven at 85°C to obtain a powder product. According to Example 1, the product was subjected to phase analysis.

[0040] (2) The preparation method of bone cement: at room temperature, according to proportioning, take by weighing 5.75gPMMA (57.5%) respectively, 0.25gBPO (2.5%), CSH (2.1g, 60%) of 3...

Embodiment 3

[0042] (1) The preparation method of strontium hydrogen phosphate powder: configure 200ml of 0.05mol / L strontium nitrate solution, and add 0.04mol urea into it and stir to dissolve to obtain A solution; configure 200ml of 0.05mol / L diammonium hydrogenphosphate solution, Obtain B solution; Pour B solution into A solution, stir and mix, the solution becomes a turbid suspension, add concentrated nitric acid (65-68%), adjust the pH value to 3, the solution becomes clear; put the clear solution into In a water bath at 100°C, react at a constant temperature for 2 hours, pour out the supernatant, wash repeatedly, filter the white precipitate with suction, dry and grind at a constant temperature in an oven at 85°C to obtain a powder product. According to Example 1, the product was subjected to phase analysis.

[0043] (2) The preparation method of bone cement: at room temperature, according to proportioning, take by weighing 4.95gPMMA (49.5%) respectively, 0.05gBPO (0.5%), CSH (1.35g,...

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Abstract

The invention relates to injectable bone cement containing strontium and a preparation method of the injectable bone cement. The injectable bone cement comprises solid phase and liquid phrase, wherein the solid phrase comprises polymethylmethacrylate, calcium sulfate hemihydrate, tetracalcium phosphate, strontium hydrogenphosphate, barium sulfate and benzoyl peroxide; the liquid phrase comprises a methyl methacrylate monomer, N,N dimethyl paratoluidine and hydroquinone; the preparation method of the injectable bone cement comprises the following steps: mixing solids and liquids at a mass ratio of 2 to 1; stirring uniformly by using a bone cement mixing and stirring system; using an injecting system to inject the bone cement; in the injectable bone cement containing the strontium, the calcium sulfate hemihydrate, the tetracalcium phosphate and the strontium hydrogenphosphate are distributed uniformly; after the injectable bone cement is implanted into a body, calcium ions and strontium ions are degraded and released gradually in the body to form a honeycomb structure and guide cells to ingrow, so that joint connection is formed so as to prevent looseness; the compressive strength of the prepared injectable bone cement containning the strontium are higher than 50 MPa. The injectable bone cement containing the strontium can be used in fracture fixation caused by osteoporosis and the like and bone defect filling.

Description

technical field [0001] The invention relates to a strontium-containing injectable bone cement and a preparation method thereof, which are mainly used in the field of orthopedic materials. Background technique [0002] PMMA (polymethyl methacrylate) bone cement is currently the most clinically used bone cement, which consists of powder and liquid. The main component of the powder is PMMA, and the main component of the liquid is MMA monomer. PMMA bone cement can be injection molded and made into any shape, and has high mechanical strength, but at the same time, PMMA bone cement still has some limitations [Belkoff, S.M et al...Temperature measurement during polymerization of polymethylmethacrylate used for vertebroplasty.Spine.28: 1555-1559], such as the monomer has certain toxicity, poor biocompatibility, and cannot be absorbed and degraded after being injected into the human body. Reaction may cause neurological impairment effect of adjunctive methylmethacrylate on failure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12
Inventor 李朝阳吕维加
Owner 山东明德生物医学工程有限公司
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