Strontium-calcium composite bone cement and preparation method thereof

A technology of bone cement and calcium nitrate, applied in the field of bone tissue engineering, can solve the problems of restricting wide application and slow degradation

Active Publication Date: 2014-12-03
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, calcium phosphate cement still has shortcomings, such as high brittleness, compact structure, slow degradation, and difficulty in adapting to the repair of bone defects in weighing parts, which limits its wide application in clinical practice.

Method used

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  • Strontium-calcium composite bone cement and preparation method thereof
  • Strontium-calcium composite bone cement and preparation method thereof
  • Strontium-calcium composite bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of monetite whiskers: configure 0.5mol / L calcium nitrate solution (200ml calcium nitrate mole is 0.5×0.2=0.1mol), add 0.6mol urea (add to mix and stir to fully dissolve, then add 0.5 200ml of mol / L diammonium hydrogen phosphate solution, mixed and stirred to obtain a suspension; then concentrated nitric acid (65-68%) was added to the suspension, the solution became clear, and the pH value was adjusted to 2, and the clear solution was dissolved at 100 React at a constant temperature in a water bath at ℃ for 2 hours, pour off the supernatant, add distilled water to wash repeatedly to remove impurity ions, and filter with suction to obtain a white precipitate. At 100°C, dry at a constant temperature and grind to obtain a powder product. The prepared product was characterized by XRD. as attached figure 1 As shown, the diffraction peak corresponds well to the standard peak (PDF09-0080), and it can be determined that the prepared product is monetite whisker. ...

Embodiment 2

[0033] (1) Preparation of monetite whiskers: configure 200ml of 0.3mol / L calcium nitrate solution, add 0.3mol urea to mix and stir to fully dissolve, then add 200ml of 0.3mol / L diammonium hydrogen phosphate solution, mix and stir Obtain a suspension; then add concentrated nitric acid (65-68%) into the suspension, the solution becomes clear, adjust the pH value to 2.5, react the clear solution at a constant temperature in a water bath at 90°C for 2.5 hours, and pour off the supernatant , add distilled water to wash repeatedly to remove impurity ions, filter with suction to obtain a white precipitate, dry at a constant temperature at 90°C, and grind to obtain a powder product. The product was subjected to phase analysis according to the method of Example 1.

[0034] (2) Preparation of bone cement: at room temperature, weigh 4.0gCSH (80%), 0.70gTTCP (14%), 0.15g monetite whiskers (3%) and 0.15gSrHPO4 (3%) respectively, mix Uniform; measure 2g of distilled water, stir and mix for...

Embodiment 3

[0036] (1) Preparation of monetite whiskers: configure 200ml of 0.05mol / L calcium nitrate solution, add 0.04mol urea to mix and stir to fully dissolve, then add 200ml of 0.05mol / L diammonium hydrogen phosphate solution, mix and stir Obtain a suspension; then add concentrated nitric acid to the suspension, the solution becomes clear, adjust the pH value to 3, and react the clear solution in a water bath at 80°C for 3 hours at a constant temperature, pour off the supernatant, add distilled water to wash and remove repeatedly Impurity ions were obtained by suction filtration to obtain a white precipitate, which was dried and ground at a constant temperature at 90°C to obtain a powder product. The product was subjected to phase analysis according to the method in Example 1.

[0037] (2) Preparation of bone cement: at room temperature, weigh 3.5g CSH (70%), 1.095g TTCP (21.9%), 0.4g monetite whiskers (8%) and 0.005g SrHPO4 (0.1%), mix well ; Measure 1.67g of 0.01mol / L polyvinyl alcoh...

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Abstract

The invention relates to strontium-containing injectable bone cement and a preparation method thereof. The strontium-calcium composite bone cement comprises the following solid phases: tetracalcium phosphate, monetite crystal whiskers, strontium hydrogen phosphate and calcium sulfate hemihydrate, and the following liquid phases: water for injection or polyvinyl alcohol, and polyethylene glycol. The solid phases and the liquid phases are separately mixed, and then solid mixture and liquid mixture are uniformly stirred and mixed in solid-liquid mass ratio of (2-3):1, so that the strontium-calcium composite bone cement is obtained. Through hydration and solidification, the final product, namely the strontium-calcium composite bone cement of calcium sulphate and strontium doped apatite, is prepared, initial strength of the bone cement can be enhanced due to needle-like morphology of monetite crystal whiskers, resistance to collapse due to water is good, degradation rate is adjustable, the bone cement does not collapse in a human body, morphology of the bone cement after solidification is of a laminate shape and rod-shaped crystals are adhered, the bone cement can be completely degraded, degradation rates of calcium sulphate and strontium-containing apatite are different, mechanical properties of the bone cement can be maintained, and repairing of coloboma in clinical application can be realized.

Description

technical field [0001] The invention relates to a strontium-calcium composite bone cement and a preparation method thereof, which are mainly used in the field of bone tissue engineering. Background technique [0002] Bone cement is a medical material widely used in orthopedic surgery. Bone cement is usually composed of powder and liquid. Mix it in a certain proportion at room temperature to undergo a curing reaction and place it in bone defects. After the reaction is over, the damaged or defective parts can be repaired. The ideal bone cement should have the characteristics of good injectability, easy operation, collapse resistance, osteoconductivity and degradability. [0003] Calcium sulfate has been studied for more than 100 years, and it has good biocompatibility and bioactivity, and can be completely degraded. Calcium sulfate has sufficient sources and is easy to sterilize. It can be widely used for defect filling in orthopedics, dentistry, and ENT. It is an excellent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/12A61L27/58
Inventor 李朝阳吕维加
Owner 山东明德生物医学工程有限公司
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