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Injectable bone cement with antioxidation characteristic as well as preparation method and application thereof

A bone cement and anti-oxidation technology, applied in the field of bone cement, can solve the problems of poor fluidity of bone cement, slow degradation speed, biocompatibility to be improved, etc., and achieve the effect of good fluidity and short curing time

Inactive Publication Date: 2015-07-22
山东明德生物医学工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a bone cement with good fluidity, suitable mechanical strength, Injectable bone cement with anti-oxidation properties for treating osteoporotic fractures with good biocompatibility and excellent degradation performance, its preparation method and use

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  • Injectable bone cement with antioxidation characteristic as well as preparation method and application thereof
  • Injectable bone cement with antioxidation characteristic as well as preparation method and application thereof
  • Injectable bone cement with antioxidation characteristic as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0026] The preparation method of the above-mentioned injectable bone cement with anti-oxidation properties comprises the following steps:

[0027] (1) Mix sulfate, phosphate, β-carotene powder and dispersant evenly by mass ratio, wherein β-carotene accounts for 0.1%-1% of the total powder mass, and dispersant accounts for 0.1%-1% of the total powder mass 0.01%-0.3%;

[0028] (2) Add the solidified liquid and stir evenly. The ratio of the added amount of the solidified liquid to the powder mixture prepared in step (1) is 1.5g / mL-2.0g / mL.

[0029] The solidified liquid is deionized water.

[0030] Use of the above-mentioned injectable bone cement with anti-oxidation properties as a bone repair material.

[0031] The invention prepares minimally invasive injectable bone cement, which has the function of bone repair and is used for preventing and treating osteoporotic fractures. Injectable materials can also promote new bone formation while repairing bone, thereby preventing os...

Embodiment 1-4

[0035] The preparation of the injectable bone cement and slurry thereof of embodiment 1-4 antioxidant bioactivity:

[0036] Bone cement powder is prepared by mixing tetracalcium phosphate and calcium hydrogen phosphate with a molar ratio of 1:2, appropriate amount of other phosphates, sulfates, β-carotene, and dispersant, and the mass of β-carotene powder accounts for 0.1%-1 %, the amount of dispersant is 0.01%-0.3% of the CPC mass.

[0037] The composition of the bone cement powder used in the examples is shown in Table 1. All four bone cements use deionized water as the solidification solution.

[0038] Table 1 Composition of several bone cement powders

[0039]

[0040]

[0041] Note: the total mass is 100%

Embodiment 5

[0042] Embodiment 5 performance test

[0043] 1. Determination of coagulation time

[0044] The setting time of the bone cement paste was measured with a cement consistency and setting time tester.

[0045] Mix the bone cement powder and the curing liquid evenly in a certain proportion, and make the well-mixed cement slurry into a sample with a height of H=10mm and a diameter of D=6mm. Time to take out. When measuring, put the sample on the glass plate so that the test needle is in contact with the slurry surface, loosen the screw suddenly, the test needle sinks into the slurry freely, and observe the value indicated by the pointer. The setting time is defined as the time elapsed from the beginning of mixing the powder until the test needle sinks into the slurry by no more than 1 mm.

[0046] 2. Determination of compressive strength

[0047]Mix the bone cement powder and solidification solution evenly in a certain proportion, put the blended cement slurry into a stainless ...

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Abstract

The invention discloses injectable bone cement with an antioxidation characteristic as well as a preparation method and application thereof. The bone cement consists of powder and liquid, wherein the powder consists of phosphate, sulfate and beta-carotene powder; the liquid consists of one or more of sodium citrate, sodium hydrogen phosphate and deionized water. The bone cement is prepared by using the preparation method which comprises the following steps: (1) uniformly mixing phosphate, sulfate, beta-carotene powder and a dispersing agent according to a mass ratio, wherein beta-carotene is 0.1-1% of the total mass and the dispersing agent is 0.01-0.3% of the total mass; (2) adding the solidified liquid to stir uniformly, wherein the proportion of the addition of the solidified liquid to the powder mixture prepared in the step (1) is 1.5-2.0 g / mL. The prepared bone cement has the characteristics of being injectable and high in strength, is capable of automatically and rapidly solidifying under physiological environment, and has good bioactivity, antioxidation characteristic and bone cell inducing characteristic.

Description

technical field [0001] The present invention relates to bone cement, in particular to an injectable bone cement with anti-oxidation property and its preparation method and application. Background technique [0002] The hallmarks of osteoporosis are decreased bone density and decreased bone strength. It is a systemic bone metabolic disorder characterized by an increased risk of fracture. Among them, the elderly have a higher incidence of osteoporosis. Osteoporosis and osteoporotic fractures have become serious public health and social problems of worldwide concern. There are 90 million osteoporosis patients in China, accounting for 7.1% of the total population; with the aging of society, bone The incidence of osteoporosis is still on the rise and is expected to increase to 221 million by 2050, of which more than half of osteoporotic fractures will occur in China. [0003] The root of osteoporosis is the destruction of bone microstructure, but bone tissue has normal calcifica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/54A61L27/50
Inventor 李朝阳邸勋崔永顺吕维加
Owner 山东明德生物医学工程有限公司
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