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Injectable porous high-strength bone repair material

A high-strength, bone repair technology, applied in the field of medical devices, can solve the problems of inability to form a porous structure, unsuitable, low strength, etc., and achieve the effects of controllable material formation rate, fast degradation rate, and good injectability.

Active Publication Date: 2010-09-01
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, calcium phosphate and calcium sulfate hemihydrate have been developed and applied as injectable bone materials in foreign countries, but the important thing is that the research on some key properties is not deep enough, and there are still some problems, which are not consistent with the ideal clinical requirements. There is still a big gap. After in-situ curing, a porous structure cannot be formed, which is not conducive to the growth of cells and the formation of new bone tissue; prefabricating a porous structure will cause further reduction in the mechanical properties of the material.
At the same time, the texture is generally brittle, and the biomechanical compatibility with the damaged tissue is not ideal. It can only be used as a filling material or slow-release material with no or very low strength. It is not suitable for use in parts with complex loading conditions. Degradability and strength There are still contradictions between, often the degradation of high strength is too slow, and the strength of fast degradation is too low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. Injectable bone repair material

[0034] (1) Prepare a multi-element phosphate calcium salt, α-CSH, and medical glass fiber in a ratio of 8:1.5:0.5 and mix uniformly to obtain a solid phase mixture. Among them, polybasic calcium phosphate is composed of ACP, TTCP, β-TCP, OCP and HA, and the mass fraction ranges are 1%-5%, 40-45%, 35-41%, 5-10%, 10-20%, respectively .

[0035] (2) Preparation of 0.01mol / ml citric acid liquid phase.

[0036] (3) The solid phase and the liquid phase are mixed and quickly stirred uniformly to prepare an injectable bone. The ratio of solid phase to liquid phase is 5:1

Embodiment 2

[0037] Example 2. Injectable bone repair material

[0038] (1) Prepare a multi-element phosphate calcium salt, α-CSH, and medical glass fiber in a ratio of 8:1.0:0.5 and mix uniformly to obtain a solid phase mixture. Among them, the polybasic calcium phosphate is composed of TTCP, β-TCP, OCP and HA, and the mass fraction ranges are 40-45%, 35-40%, 1-5%, and 10-20% respectively.

[0039] (2) Preparation of 0.01mol / ml citric acid liquid phase.

[0040] (3) The solid phase and the liquid phase are mixed and quickly stirred uniformly to prepare an injectable bone. The ratio of solid phase to liquid phase is 5:1

Embodiment 3

[0041] Example 3: Injectable bone repair material

[0042] (1) Prepare a multi-element phosphate calcium salt, α-CSH, and medical glass fiber in a ratio of 9.5:3:0.5 and mix uniformly to obtain a solid phase mixture. Among them, the polybasic calcium phosphate is composed of TTCP, DCPD, α-TCP, OCP and HA, and the mass fraction ranges are 30-35%, 40-47%, 13-20%, 5-10%, and 10-20% respectively.

[0043] (2) Prepare a liquid phase of 0.1 mol / ml sodium hydrogen phosphate.

[0044] (3) The solid phase and the liquid phase are mixed and quickly stirred uniformly to prepare an injectable bone. The ratio of solid phase to liquid phase is 8:1

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PUM

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Abstract

The invention relates to an injectable porous high-strength bone repair material. The material can reach a bone defect part through injection and is quickly solidified to repair bone defect. The material mainly comprises a solid phase and a liquid phase, wherein the solid phase consists of polyphosphoric acid calcium salt, alpha-calcium sulfate hemihydrate and reinforced fiber; and the liquid phase is one or mixed solution of more of citric acid, sodium phosphate, sodium hydrogen phosphate, deionized water, normal saline, blood from a patient and the like. The injectable bone material has good liquidity and clinically satisfactory injectability, collapse resistance and high strength.

Description

Technical field [0001] The invention belongs to the field of medical equipment. More specifically, the present invention relates to an injectable porous high-strength bone repair material, which can be injected to reach the bone defect site and quickly solidify to repair the bone defect. technical background [0002] With the development of minimally invasive surgery technology, injectable bone repair material has become a kind of bone tissue regeneration and repair material that is urgently needed in clinic. It has small tissue damage, does not damage the blood supply of the repair area, is formed in situ, and is easy to operate. , It is highly valued for its advantages such as greatly reducing the pain of patients, and its application prospects are broad. At present, the injection-type self-curing bone repair materials with development potential on the market are mainly polyacrylic acid (PMMA), calcium phosphate and calcium sulfate hemihydrate three types of materials, and alm...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/56
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN LANDO BIOMATERIALS
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