Graphene oxide modified bone cement and preparation method

A technology of graphene modification and bone cement, which is applied in the fields of medical formula, medical science, tissue regeneration, etc., can solve the problems of slow formation of degradation rate, low mechanical strength, slow degradation rate, etc., and achieve good biocompatibility and reliability Degradability, improvement of mechanical properties, effect of good mechanical properties

Inactive Publication Date: 2017-01-25
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Their disadvantages are: injectable calcium sulfate bone substitutes have a short injectable time and degrade faster than their own new bone formation in the body, so they are not suitable for repairing larger and longer healing bones. Defect conditions...

Method used

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  • Graphene oxide modified bone cement and preparation method
  • Graphene oxide modified bone cement and preparation method
  • Graphene oxide modified bone cement and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Bone cement composite powder includes α-calcium sulfate hemihydrate, strontium-doped hydroxyapatite powder. At room temperature, weigh 4g (80%) of calcium sulfate hemihydrate and 1g (20%) of strontium-doped hydroxyapatite, and mix them uniformly; The powder (liquid-solid ratio is 0.5mL / g) is mixed and stirred for 2 minutes, and the injectable time is about 9.4 minutes. figure 1 shown. The cured bone cement was ground into powder for SEM characterization, as shown in the attached figure 2 As shown, the cured bone cement is distributed in a columnar shape, and hydroxyapatite is distributed on it. The attachment of hydroxyapatite does not affect the basic morphology of the bone cement, and can also improve the biological activity of the bone cement.

Embodiment 2

[0024] Preparation of bone cement composite powder: at room temperature, weigh 4g (80%) calcium sulfate hemihydrate and 1g (20%) strontium-doped hydroxyapatite, mix well; weigh 2.5mL with a mass fraction of 0.004% The graphene oxide aqueous solution was mixed with the solid phase powder (liquid-solid ratio: 0.5mL / g) and stirred for 2 minutes, and the injectable time was about 8.6 minutes. Carry out scanning electron microscope observation to curing product according to embodiment 1, and carry out phase analysis (namely XRD characterization) to the sample after curing, as attached image 3 As shown, the cured bone cement components are calcium sulfate dihydrate, hydroxyapatite and carbon, and the main component is calcium sulfate dihydrate, which shows that calcium sulfate hemihydrate quickly turns into calcium sulfate dihydrate during the curing process. Studies have shown that calcium sulfate dihydrate can promote the attachment of osteoblasts and promote osteogenesis, while ...

Embodiment 3

[0026] At room temperature, weigh 4g (80%) of calcium sulfate hemihydrate and 1g (20%) of strontium-doped hydroxyapatite, and mix them uniformly; The powder (liquid-solid ratio is 0.5mL / g) was mixed and stirred for 2 minutes, and the injectable time was about 9.6 minutes. Carry out phase analysis and scanning electron microscope observation to solidified product according to embodiment 2, and carry out compressive strength test to bone cement sample, compressive strength test sample is cylindrical (Φ 6mm * 12mm), and compressive strength average value is 6.42Mpa, in line with the requirements of human cancellous bone compressive strength (5 ~ 10Mpa), as attached Figure 4 It shows that the addition of graphene oxide can indeed improve the compressive strength of bone cement. After curing, the bone cement was soaked in SBF solution, and the collapse resistance was good. Embodiment 4:

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Abstract

The invention relates to graphene oxide modified bone cement and a preparation method. The graphene oxide modified bone cement comprises powder and solidifying liquid, wherein the powder is formed by compounding calcium sulfate hemihydrate and hydroxyapatite doped with 5-10% of strontium, and the solidifying liquid is a graphene oxide aqueous solution. The preparation method comprises the following steps: proportionally preparing the powder of calcium sulfate hemihydrate and hydroxyapatite doped with 5-10% of strontium; adding the solidifying liquid according to a liquid-solid ratio of 0.5mL/g and mixing; stirring uniformly; and solidifying at room temperature to obtain injectable bone cement. The graphene oxide has good mechanical property and can be highly dispersed in an aqueous solution or organic solvent; and by adding the graphene oxide, the mechanical property of the bone cement can be enhanced. The bone cement material prepared by the method has the characteristics of strong collapse resistance, good injectable property and high strength and also has good biocompatibility and biodegradability. The bone cement can be used for filling and repairing various bone defects and is applied to the fields of tissue engineering and medicine.

Description

technical field [0001] The invention relates to an injectable bone cement for human hard tissue repair and a preparation method, which is mainly used in the fields of biomedical materials and the like; in particular, it relates to a graphene oxide modified bone cement and a preparation method. Background technique [0002] The loss of bone tissue defects caused by trauma, traffic accidents, resection and other disease operations is very common, which not only brings great pain to patients, but also makes their lives extremely inconvenient, so a large amount of bone tissue is required. Restoration materials. Bone defect has always been one of the problems faced by orthopedics. Common methods for repairing bone defects generally include autologous bone grafting, allogeneic bone grafting, and artificial bone repair. As the recognized "gold standard" of bone transplantation, autologous bone transplantation has no immune rejection and high biological safety, but the amount of b...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61L27/08A61L27/50A61L27/58
CPCA61L27/12A61L27/025A61L27/08A61L27/50A61L27/58A61L2400/06A61L2430/02
Inventor 成艳琪李朝阳梁砚琴朱胜利崔振铎杨贤金
Owner TIANJIN UNIV
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