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Injectable bone repair material and preparation method thereof

A bone repair and dopamine technology, which is applied in the field of biomedical materials and biomedical engineering, can solve the problems of poor yield strength and impact resistance, unsuitable use, low shear and tensile strength, etc., and achieves enhanced mechanical properties. Effect

Active Publication Date: 2017-08-18
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these products generally have low shear and tensile strength, especially poor toughness, brittle texture, poor yield strength and impact resistance, and can only be used as fillers in unstressed parts or combined with external fixation, not suitable for The use of parts under load limits its wide application
In addition, calcium phosphate bone materials have contradictions between degradability and strength, and contradictions between porous structure and strength.
Bone repair materials are processed into a dense structure, which is not conducive to the migration and growth of cells and the formation of new bone, and is also not conducive to the combination and fixation of grafts and surrounding tissues. The overall degradation rate of the material cannot be well matched with the rate of new bone formation.
In addition, the cohesiveness of bone material can not be better improved

Method used

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  • Injectable bone repair material and preparation method thereof

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preparation example Construction

[0025] The present invention also provides a preparation method of the above-mentioned injectable bone repair material, such as figure 1 shown, including the following steps:

[0026] S101: React dopamine aqueous solution with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl), add carboxylated polysaccharide solution after the reaction, and control the pH to 5.0 , followed by dialysis and freeze-drying to obtain polysaccharide-dopamine grafts;

[0027] S102: Mix the polysaccharide-dopamine graft, buffer salt, and water to prepare a solidified solution, where the mass fraction of the solidified solution is 0.1% to 5%;

[0028] S103: The powder is mixed with the solidification liquid, injected into a mold or manually extruded and kneaded into a fixed shape, and solidified within 10 minutes to obtain an injectable bone repair material.

[0029] The preparation method of the carboxylated polysaccharide in step S101 comprises: adding tetramethylpiperidinium ox...

Embodiment 1

[0037] Prepare 500 mL of 0.5% agarose solution, add 0.02 g of tetramethylpiperidine oxide (TEMPO) and 0.4 g of sodium bromide, adjust the pH to 5.0 with sodium hydroxide, and add 4 mL of 10% sodium hypochlorite after reacting for 1 hour. 1mol / L sodium hydroxide was used to adjust the pH to maintain at 10, and reacted for 4 hours. The polysaccharide material was precipitated by adding excess absolute ethanol, washed twice with ethanol and acetone, and then dried by rotary evaporation to obtain a powder material, which was dissolved in water and titrated with hydrochloric acid until the pH was 7.0. The dialysis bag was dialyzed for 3 days and then freeze-dried to obtain carboxylated agarose;

[0038] Prepare 5 mg / mL dopamine aqueous solution, add 1 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) and react for a period of time at 4 degrees Celsius, After the reaction, add 3mg / mL carboxylated agarose solution, control the pH to 5.0, react at room tempe...

Embodiment 2

[0045] Prepare 400 mL of 1% dextran solution, add 0.01 g of tetramethylpiperidine oxide (TEMPO) and 0.35 g of sodium bromide, adjust the pH to 5.0 with sodium hydroxide and add 5 mL of 10% sodium hypochlorite after reacting for 1 hour. Adjust the pH with 1mol / L sodium hydroxide to maintain at 10, and react for 4 hours. The polysaccharide material was precipitated by adding excess absolute ethanol, washed twice with ethanol and acetone, and then dried by rotary evaporation to obtain a powder material, which was dissolved in water and titrated with hydrochloric acid until the pH was 7.0. The dialysis bag was dialyzed for 3 days and then freeze-dried to obtain carboxylated dextran;

[0046] Prepare 4 mg / mL dopamine aqueous solution, add 0.8 mg / mL 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) and react for a period of time at 4 degrees Celsius After the reaction, add 5mg / mL carboxylated dextran solution, control the pH to 5.0, react at room temperature (us...

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Abstract

The invention provides an injectable bone repair material, which comprises powder and a solidification liquid, wherein the solidification liquid is prepared from a polysaccharide-dopamine graft, a buffer salt and water. The polysaccharide-dopamine graft is added to the solidification liquid of the bone repair material, so that the compatibility and the cohesiveness of bone cement and tissues and bones are strengthened, the powder and the liquid can be prevented from being scattered after being mixed and the injectable bone repair material can be manually molded. The invention further provides a preparation method of the injectable bone repair material.

Description

technical field [0001] The invention belongs to the fields of biomedical materials and biomedical engineering. More precisely, the present invention relates to an injectable bone repair material and its preparation method. [0002] technical background [0003] At present, the materials used to repair bone defects in stressed parts mainly include polymethyl methacrylate (PMMA) bone repair and alloy materials, both of which have good mechanical properties. However, PMMA has the disadvantages of residual toxic monomers, no biological activity, and no degradation. The elastic modulus of the metal is too high, the wear and corrosion problems in the body lead to the loosening of the prosthesis, and there are also problems such as the accumulation of corroded heavy metal ions in the body. On the contrary, calcium phosphate-based bone repair materials have good biocompatibility, promote regeneration, and resemble natural bone components. In the past few decades, a variety of calc...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/12A61L27/02A61L27/10A61L27/32A61L27/50A61L27/56A61L27/58
CPCA61L27/025A61L27/10A61L27/12A61L27/20A61L27/32A61L27/50A61L27/56A61L27/58A61L2300/412A61L2400/06C08L5/00
Inventor 储彬陈昌盛李小丽王明波刘伟强
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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