Method for preparing hemostatic 6-amino caproic acid

Abstract

The invention discloses a preparation method of 6-aminocaproic acid which is a hemostatic. The preparation method is characterized in that caprolactam is dissolved in diluted hydrochloric acid, heated and refluxed to produce 6-aminocaproic acid hydrochloride which is neutralized by spherical macro-porous styrene type weak alkaline anion exchange resin, thereby acquiring the product after treatment. Compared with other preparation methods, the reaction condition of the method is mild, and metal ion can not be mixed easily, the method is more scientific and rational, the standard of the burn residue required by the original material quality can be realized more easily, white crystal can be obtained from the product without activated carbon decolorizing, the operation is simple, the synthesizing cost is reduced and mass production of the technology is more suitable.

Description

【Technical field】 [0001] The invention relates to the technical field of organic synthesis, in particular to a preparation method of hemostatic drug 6-aminocaproic acid. 【Background technique】 [0002] 6-aminohexanoic acid (6-Aminohexanoic acid), molecular formula: C 6 h 13 NO 2 , is a hemostatic agent widely used at home and abroad at present. It has obvious curative effect on certain severe bleeding caused by increased fibrinolytic activity. Tract bleeding and obstetrics and gynecology hemorrhagic disorders. In the prior art, the following patents and documents relate to the preparation method of 6-aminocaproic acid, such as U.S.Pat2 453,234; Org.syn.Coll.vol II, 28 (1943); Org.syn.Coll.Vol IV, 39 (1963); Hebei Chemical Industry, 2003, April, 24; Organic Synthesis Code (Edited by Fan Nengting), P394, etc. The above-mentioned patented technology is related to the literature method, and its synthetic route mainly contains the following two methods: [0003] Method 1: U...

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Problems solved by technology

[0006] In the first method, the 6-aminocaproic acid hydrochloride aqueous solution containing hydrochloric acid is directly passed through the strong acidic cation exchange resin, which needs to be left standing overnight, which takes a long time; without concentration, because it contains a large amount of hydrochloric acid, it is then eluted with ammonia water, and the Standing overnight, the amount of ammonia water is large, time-consuming, and cumbersome to operate; activated carbon decolorization takes nearly an hour, which takes a long time and has a large loss, which increases the operating procedures and increases the synthesis cost.

Resin adsorption is not used in method 2, but the addition of yellow lead powder, aluminum hydroxide, and silver oxide significantly increases the cost; using toxic hydrogen sulfide to remove metal ions is complicated and dangerous

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