Preparation methods and applications of benzylpenicilloic acid artificial antigen and benzylpenicilloic acid artificial antibody

A technology of penicillin thiazole and penicillin, which is applied in the field of preparation of benzyl penicillin artificial antigen and its antibody, achieving a high degree of similarity and retaining complete effects
CN103483445AInactive Publication Date: 2014-01-01TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Publication Date
2014-01-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses preparation methods and applications of a benzylpenicilloic acid artificial antigen and a benzylpenicilloic acid artificial antibody, and relates to a method for simply, quickly and effectively detecting penicillin G and a degradation product of penicillin G, namely benzylpenicilloic acid. The specific antibody to penicillin G and the degradation product of penicillin G, namely benzylpenicilloic acid, is prepared by designing and synthesizing a hapten and the artificial antigen of a penicillin veterinary drug penicillin G with a 6-aminocaproic acid molecular structure and a beta-lactam ring molecular structure, and the degradation product of penicillin G, namely benzylpenicilloic acid; a molecular specific antigenic determinant of the veterinary drug is highlighted; the chemosynthesis difficulty is overcome; and an immune animal induces to generate the specific antibody with very high affinity.
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Description

technical field

[0001] The invention belongs to the technical field of chemistry, and relates to a preparation method and application of benzyl penicillin thiazole acid artificial antigen and antibody thereof. Background technique

[0002] Penicillin G (also known as benzyl penicillin) is a kind of penicillin antibiotics. Penicillin antibiotics are the first class of antibiotics to enter clinical application, and they are also the antibiotics with the largest production and usage in my country. Penicillin antibiotics have become the most commonly used drugs to treat diseases of dairy cows and other edible animals. However, due to irregular drug use and improper collection of milk samples, the phenomenon of penicillin drug residues in food of animal origin is serious. Residues of penicillin drugs in the body will cause severe allergic reactions, and the rate of allergic reactions ranks first among all kinds of drugs. Because penicillin is easily degraded into penicilloic aci...

Claims

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