37 results about "L-2-Aminobutyric Acid" patented technology

Disclosed are: an agent for imparting body taste comprising a substance, which is obtained by searching for a number of variation compounds having CaSR agonistic activity and finding a substance that has an improved effect of imparting body taste, in particular, an effect of imparting body taste of the first taste-type, and high stability and can be conveniently produced at a low cost; and a composite agent for imparting body taste which comprises said substance together with another substance having CaSR agonistic activity. Specifically disclosed are: an agent for imparting body taste which comprises gamma-Glu-Abu (L-gamma-glutamyl-L-2-aminobutyric acid); and a composite agent for imparting body taste which comprises a combination of said substance with another substance having CaSR agonistic activity.

The invention discloses a method for producing L-2-aminobutyric acid, and the method comprises the following step: catalyzing L-threonine utilized as a raw material through an enzyme catalysis system consisting of threonine deaminase, L-amino acid dehydrogenase and coenzyme regeneration systems, thus producing the L-2-aminobutyric acid. The method for producing theL-2-aminobutyric acid has the advantages that the raw material is low in price, the property is stable, and the production cost of the L-2-aminobutyric acid can be greatly lowered, the conversion rate and product concentricity are high, no influence caused by byproducts exists, and the method is suitable for industrialization application.

The invention relates to a preparation method of high-quality S-2-chlorobutanol. The method comprises the following steps: with L-2-aminobutyric acid prepared by a biological reduction transformation method as a raw material, preparing the S-2-chlorobutanol by adopting a diazotization chlorination method; further esterifying, and reducing with sodium borohydride / titanium tetrachloride, so as to obtain the product. According to the prepared high rotary S-2-chlorobutanol, the EE value is over 99%; and the S-2-chlorobutanol is good in repeatability and stable in process.

A yeast extract containing 0.2% or more of γ-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and γ-Glu-Abu (L-γ-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.

The invention relates to a method for preparing L-2-aminobutyric acid through biotransformation of whole cells. The method is as follows: expressing threonine deaminase and leucine dehydrogenase in series, cloning the chloramphenicol resistance expression vector, realizing the co-expression of the two enzymes in the same bacterium; cloning the formate enzyme into kalamycin Express on the resistant pET-28a vector, and express in tandem with the pcnB gene in the rate-limiting step of the coenzyme I metabolic pathway in E. coli to achieve high expression of the two enzymes; transform the two resistant expression vectors into the same bacterium Co-expression in the same genus of the four enzymes was achieved, and the expression of four enzymes in the same genus was realized; the whole cell of E. coli containing the four enzymes was fermented and expressed in E. coli, and the synthesis from threonine to L-2-aminobutyric acid was realized. Bioreductive transformation. The invention realizes high-efficiency conversion of 2-ketobutyric acid in the conversion system without adding coenzymes, and has low cost and simple method.

A cocrystal of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid and an amino acid, in particular L-valine or L-2-aminobutyric acid, their preparation processes, as well as the preparation process of Ambrisentan or Darusentan using any of the cocrystals of the invention.