Use of peptide for imparting body taste

A thick flavor imparting agent and concentration technology, applied in the field of thick flavor imparting agent and compound thick flavor imparting agent, to achieve the effect of excellent stability

Active Publication Date: 2012-05-30
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, some γ-glutamyl peptides having γ-glutamine at the N-terminus are known to be synthesized as substrates in studies of enzyme activity, etc. (Patent Document 2, Non-Patent Documents 1 to 3) , but there is no known example of using γ-Glu-Abu as a rich flavor imparting agent or seasoning, or for food use

Method used

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  • Use of peptide for imparting body taste
  • Use of peptide for imparting body taste
  • Use of peptide for imparting body taste

Examples

Experimental program
Comparison scheme
Effect test

specific example

[0050] In addition, in the complex flavor-imparting agent of the present invention, the amino acid or peptide used in combination with γ-Glu-Abu may have γ-Glu-X-OCH(Z)CO 2 Peptide derivatives of the structure of H. Here, X in the formula represents an amino acid or an amino acid derivative, and Z represents H (hydrogen atom) or CH 3 (methyl). In addition, in the above formula γ-Glu-Val-Y, Y is a compound of GlyA or LacA. As specific examples, γ-Glu-Val-GlyA, γ-Glu-tLeu-GlyA, γ-Glu-Abu-GlyA, γ-Glu-Val-LacA, γ-Glu-tLeu-LacA and γ-Glu- Abu-LacA et al. Furthermore, GlyA means glyoxylic acid, and LacA means lactic acid. Lactic acid may be either S-type or R-type, preferably S-type. The structural formulas of these compounds are as follows:

[0051] chemical formula 1

[0052]

[0053] chemical formula 2

[0054]

[0055] chemical formula 3

[0056]

[0057] chemical formula 4

[0058]

[0059] chemical formula 5

[0060]

[0061] chemical formula 6

[00...

Embodiment

[0141] Preparation of various samples

[0142] γ-L-Glu-L-Abu (Abu: α-aminobutyric acid, Bachem Feinchemikalien AG), γ-L-Glu-L-Ala (Bachem Feinchemikalien AG), γ-L-Glu-L-Cys (Sigma- Aldrich Japan Co., Ltd.), γ-L-Glu-L-Thr (Kokudo Chemical Co., Ltd.) and other four kinds of purchased products were used.

[0143] Synthesis of γ-L-Glu-L-Val

[0144] (Step 1) Z-L-Glu-OBzl (N-α-benzyloxycarbonyl-L-glutamic acid α-benzyl ester, 7.619g, 20.51mmol) and Val-OBzl·HCl (L-valine benzyl ester salt Salt, 5 g, 20.51 mmol) was dissolved in dichloromethane (100 ml), and the solution was kept at 0°C. Triethylamine (3.2ml, 22.57mmol), HOBt (1-hydroxybenzotriazole, 3.053g, 22.57mmol) and WSC·HCl (1-ethyl-3-(3-dimethylaminopropyl) Carbodiimide hydrochloride, 4.326 g, 22.57 mmol) was added to the solution and stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (220 ml). The solution was partitio...

Embodiment 1

[0178] Example 1 Evaluation of rich taste imparting activity

[0179] For γ-Glu-Abu, the strength of the kokumi-imparting activity was examined by a quantitative sensory evaluation experiment.

[0180] The quantitative sensory evaluation experiment was implemented as follows. In distilled water containing sodium glutamate (0.05g / dl), inosinic acid (0.05g / dl), sodium chloride (0.5g / dl), the test compound was mixed at 0.001 ~ 0.5g / dl In this case, the strength of the kokumi-imparting activity was determined. After the sample was dissolved, the sample that was acidic to the non-added control was used after adjusting the pH to a range of ±0.2 relative to the non-added control with NaOH. For the sensory evaluation, control: 0 points, strong: 3 points, very strong: 5 points, and n=4 were implemented. In addition, in order to clarify the scale more clearly, the first taste and the middle aftertaste of 0.001 g / dl γ-Glu-Val-Gly were each taken as 3.0 points. In addition, the so-c...

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PUM

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Abstract

Disclosed are: an agent for imparting body taste comprising a substance, which is obtained by searching for a number of variation compounds having CaSR agonistic activity and finding a substance that has an improved effect of imparting body taste, in particular, an effect of imparting body taste of the first taste-type, and high stability and can be conveniently produced at a low cost; and a composite agent for imparting body taste which comprises said substance together with another substance having CaSR agonistic activity. Specifically disclosed are: an agent for imparting body taste which comprises gamma-Glu-Abu (L-gamma-glutamyl-L-2-aminobutyric acid); and a composite agent for imparting body taste which comprises a combination of said substance with another substance having CaSR agonistic activity.

Description

technical field [0001] The present invention relates to a kokumi-imparting agent and a composite kokumi-imparting agent comprising a peptide exhibiting CaSR agonist activity. The present invention also relates to a seasoning containing a peptide exhibiting CaSR agonist activity at a certain concentration or more. Background technique [0002] In recent years, with the diversification of dietary life, consumers' demand for taste has been increasing, and accordingly, it is impossible to use only five kinds of sweet, salty, sour, bitter, and umami to be able to impart "strong taste" The demand for excellent rich taste imparting agents is also increasing. [0003] In addition, calcium sensing receptor (Calcium Sensing Receptor, CaSR), also known as calcium receptor, the receptor signal regulates various functions in vivo, and substances with CaSR agonist activity can be used as strong taste imparting agent (patent document 1, 3, non-patent literature 4). [0004] There are va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/228A23L27/20A23L27/21A23L27/22
CPCA23L1/228A23L1/227A23L27/21A23L27/22A23L27/20
Inventor 二木史惠安田礼子佐藤诚一宫木贵志宫村直宏江藤让
Owner AJINOMOTO CO INC
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