Preparation method of S-(+)-2-aminobutanamide hydrochloride

A technology of aminobutyramide and aminobutyric acid is applied in the directions of microorganism-based methods, biochemical equipment and methods, microorganisms, etc., and can solve the problems of the impact of splitting and purification processes, unstable product quality, and large environmental hidden dangers. The effect of environmental protection process, low equipment requirements and low raw material cost

Inactive Publication Date: 2013-04-17
姚强
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Problems solved by technology

However, in actual production, the crude product of (±)-2-aminobutyramide contains many unknown impurities, which has a great impact on the subsequent resolu

Method used

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Embodiment Construction

[0016] The technical solution of the present invention will be further described below in conjunction with specific examples, and the examples given are only general illustrations to the method of the present invention, which help to better understand the present invention, but do not limit the scope of the present invention.

[0017] According to the present invention, the A-type Escherichia coli whole cell source reference method of the genetically engineered Escherichia coli containing the L-threonine deaminase gene plasmid is constructed (AbreScia P, et, al. Threonine deaminaSe: AutogenouS regulator of the ilv geneS in EScherichia coli K-12. Molecular and General GeneticS MGG, 1979, 171, 261-275), whole cells of type A Escherichia coli were added to PLP (pyridoxal 5-phosphate) when expanding the culture. The type B Escherichia coli whole cell of the genetically engineered Escherichia coli containing L-leucine dehydrogenase and formate dehydrogenase gene plasmids is derived ...

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Abstract

The invention provides a production method of S-(+)-2-aminobutanamide hydrochloride which is a key intermediate necessary for synthesizing anti-epileptic chiral drug, namely levetiracetam. The method comprises the following steps of: using L-threonine as an initial raw material, preparing L-2-aminobutyric acid by using a biotransformation method, and then performing esterification and ammonolysis reaction to obtain a target compound. According to the method provided by the invention, biotransformation and chemical synthesis are combined, and the good optical selectivity of the biotransformation is utilized for generating the L-2-aminobutyric acid, the reaction condition is mild and simple, the raw material cost is low, an organic solvent is not necessary, the process is environment-friendly, the purity of an isomer is high, and both the conversion rate and the yield are high; and therefore, the S-(+)-2-aminobutanamide hydrochloride is suitable for industrial production.

Description

technical field [0001] The invention relates to a key intermediate required for the synthesis of an antiepileptic chiral drug levetiracetam S The preparation method of -(+)-2-aminobutyramide hydrochloride belongs to the technical field of chiral compounds. Background technique [0002] Levetiracetam is a new pyrrolidone drug with a new anti-epileptic mechanism developed by Belgian UCB company. It is mainly used for the treatment of localized and secondary generalized epilepsy. Spectrum antiepileptic drugs. Etiracetam that has been marketed has R , S Two optical enantiomers. Its dextrorotatory form of dexvetiracetam has only slight or insignificant pharmacological effects on inhibiting epileptic seizures, while the levorotatory form of dexvetiracetam is a safe and efficient antiepileptic drug that can effectively control epileptic seizures. Compared with piracetam, it has the characteristics of high therapeutic index, good safety and mild side effects. [0003] Currentl...

Claims

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Application Information

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IPC IPC(8): C12P13/02C12R1/19
Inventor 姚强
Owner 姚强
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