4 results about "Etiracetam" patented technology

This application relates to the field of analytical detection technology, specifically to sample pretreatment methods, kits, and detection methods for the detection of antiepileptic drugs. The sample pretreatment method for the detection of antiepileptic drugs in this application includes one or more of the following antiepileptic drugs: valproic acid, carbamazepine, phenytoin, levetiracetam, lamotrigine, and phenobarbital. The sample pretreatment method includes the following steps: mixing magnetic beads with an activation solution to prepare a magnetic bead suspension; mixing the sample to be tested, the magnetic bead suspension, and an internal standard solution, and separating the supernatant and the magnetic bead complex after magnetic adsorption treatment; adding an eluent to the magnetic bead complex, and collecting the magnetic bead-target complex after elution treatment; adding an elution buffer to the magnetic bead-target complex, and collecting the supernatant after elution treatment for detection. The above sample pretreatment method is simple to operate, time-saving, and low-cost, providing key technical support for the efficient quantitative detection of antiepileptic drugs.

This invention relates to the field of pharmaceutical analysis technology, specifically to a method for determining the content of L-2-aminobutyric acid (GABA), a degradation impurity, in a concentrated solution of levetiracetam for injection. The method includes the following steps: diluting the concentrated levetiracetam for injection with a 50% acetonitrile aqueous solution, and then determining the content using high-performance liquid chromatography (HPLC) with a UV detector. C0.05 is also used. 18 The chromatographic column uses an aqueous solution of ammonium dihydrogen phosphate and acetonitrile as the mobile phase. This invention provides an accurate method for determining the degradation impurity L-2-aminobutyric acid in levetiracetam, which is highly specific, sensitive, accurate, and easy to operate, effectively controlling the quality of concentrated levetiracetam injection solutions.

The application provides a synthesis method of levetiracetam, wherein starting material I is reacted with SOCl2 under the action of a solvent A to generate an intermediate I; the intermediate I is reacted with starting material II under the action of a solvent B to generate an intermediate II; and the intermediate II is reacted with 4-chlorobutyryl chloride under the action of a solvent C to generate levetiracetam. The method is simple in operation, mild in reaction condition, high in yield, low in cost, friendly to the environment and suitable for industrialized mass production of levetiracetam.

The invention relates to a crystal form B of (S)-2-aminobutanamide hydrochloride, a preparation method of the crystal form B and a method for preparing levetiracetam by using the novel crystal form. The novel crystal form can improve the reaction yield and product purity of subsequent levetiracetam.