Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of levetiracetam tablet and preparation method thereof

A technology of tablet and colloidal silicon dioxide, which is applied in the direction of pill delivery, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of low production cost, stability, poor dissolution effect of tablet molding, etc., to achieve Low production cost, saving man-hours of process operation, good dissolution effect

Active Publication Date: 2021-11-02
HINYE PHARM CO LTD
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the above-mentioned problems existing in the prior art, the present invention aims to provide a preparation method of levetiracetam tablet, which can well solve the stability of levetiracetam in the preparation development process , tablet molding, poor dissolution effect, etc., and the process is simple, the production cost is low, and it is suitable for commercial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of levetiracetam tablet and preparation method thereof
  • A kind of levetiracetam tablet and preparation method thereof
  • A kind of levetiracetam tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of levetiracetam tablet, described preparation method comprises the following steps:

[0038] (1) Weighing and preparing materials: carry out weighing and preparing materials according to the prescription ratio in the table below; Table 1

[0039]

[0040] (2) Preparation method

[0041] Table 2

[0042]

[0043]

Embodiment 2

[0045] Get the levetiracetam tablet that different prescriptions prepare among the embodiment 1, measure friability, investigate its composition

[0046] Formability; The experimental results are as follows: According to the measurement results, it can be known that the tablet is prepared by hydroxypropyl cellulose whose model is EXF, the friability of the plain tablet is small, and the formability is better.

[0047] table 3

[0048] Prescription 1 Prescription 2 Prescription 3 Prescription 4 Friability (%) 0.50 (with missing corner) 0.52 (with missing corner) 0.45 (with slight chipping) 0.33 (no chipped corner) Hardness (kg) 12-14 12-15 14-17 14-17

[0049] Note: During the testing of hardness and friability in this example, 10 preparations of the same batch were taken for each test, and the hardness data in Table 3 is the hardness distribution range of the 10 preparations.

Embodiment 3

[0051] Table 4

[0052]

[0053] Preparation

[0054] table 5

[0055]

[0056]

[0057] It can be seen from the above examples that the addition method of colloidal silicon dioxide has a great influence on the forming of the tablet. When colloidal silicon dioxide is added in the form of internal addition and external addition at the same time, the compressibility of the material is significantly improved, and the plain The hardness of the tablet increases obviously, and the friability decreases obviously.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of pharmaceutical preparations, in particular to a levetiracetam tablet and a preparation method thereof. The preparation method comprises the following steps: step 1: sieve levetiracetam, hydroxypropyl cellulose, croscarmellose sodium and part of colloidal silicon dioxide together for later use; step 2: sift the After the granulation materials are mixed, magnesium stearate is added and mixed evenly to obtain a premixed powder; step 3: the premixed powder in step 2 is placed in dry granulation and granulated to obtain a mixture of granules and powder; step 4: The mixture of granules and powder after the granulation in Step 3 is mixed with the remaining colloidal silicon dioxide and then compressed into tablets; Step 5: Coating. The preparation method provided by the invention has the advantages of simple technological process, strong operability, low production cost and stability.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a levetiracetam tablet and a preparation method thereof. Background technique [0002] Levetiracetam is a pyrrolidone derivative whose chemical structure is not related to existing antiepileptic drugs. The antiepileptic effects of levetiracetam have been evaluated in various animal models of epilepsy. Levetiracetam has no inhibitory effect on isolated seizures induced by maximal stimulation with electric current or various convulsants, and shows only weak activity in submaximal stimulation and threshold tests. However, protection was observed against generalized seizures secondary to focal seizures induced by pilocarpine and kainic acid, two chemical convulsants that mimic the properties of complex partial seizures in some humans with secondary generalized seizures . Levetiracetam has inhibitory effects on both the ignition process and the ignition state in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K47/38A61K47/04A61K31/4015A61P25/08
CPCA61K9/2009A61K9/2054A61K9/2095A61K9/28A61K31/4015A61P25/08
Inventor 陶佑波高欣彭慧王宇杰王衡新宋志林
Owner HINYE PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com