Green production method and device of levetiracetam key intermediate S-2-methyl aminobutyrate

The technology of methyl aminobutyrate and S-2- is applied in the field of levetiracetam key intermediate S-2-aminobutyric acid methyl ester, which can solve problems such as environmental pollution and achieve the effect of environmental protection of the process.

Pending Publication Date:
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the disadvantage of this method is also more significant, that is, a large amount of hydrogen chloride and sulfur dioxide gas will be produced in the reaction process, and the discharge of this gas has caused serious pollution to the environment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Green production method and device of levetiracetam key intermediate S-2-methyl aminobutyrate
  • Green production method and device of levetiracetam key intermediate S-2-methyl aminobutyrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: A kind of green production method of levetiracetam key intermediate S-2-aminobutyric acid methyl ester comprises the following steps:

[0034] S1. Will S -2-aminobutyric acid and methanol in a molar ratio of 1:1, S -2-Aminobutyric acid and thionyl chloride are pumped into reactor 1 at a molar ratio of 1:5, heated to a reaction temperature of 50°C, and stirred vigorously for 5 hours, and the hydrogen chloride and sulfur dioxide produced by the reaction are extracted from the top of reactor 1;

[0035] S2. Pump the hydrogen chloride and sulfur dioxide extracted from the top of the reaction kettle 1 into the bottom of the gas absorption tower 2, pump the alkaline aqueous solution into the top of the gas absorption tower 2, and pump the potassium hydroxide aqueous solution into the top of the tower at a flow rate of 0.1mol / h to absorb hydrogen chloride and sulfur dioxide gas;

[0036] S3. The reaction solution is discharged from the bottom of the reaction ke...

Embodiment 2

[0039] Embodiment 2: A kind of green production method of levetiracetam key intermediate S-2-aminobutyric acid methyl ester comprises the following steps:

[0040] S1. Will S -2-aminobutyric acid and methanol in a molar ratio of 1:3, S -2-Aminobutyric acid and thionyl chloride are pumped into the reaction kettle 1 according to the molar ratio of 1:1, heated to a reaction temperature of 60°C, vigorously stirred for 7 hours, and the hydrogen chloride and sulfur dioxide produced by the reaction are extracted from the top of the reaction kettle 1;

[0041] S2. pump the hydrogen chloride and sulfur dioxide extracted from the top of the reactor 1 into the gas absorption tower 2 bottom, the gas absorption tower 2 top is pumped into the alkaline aqueous solution, and the tower top is pumped into the sodium carbonate aqueous solution with a flow rate of 0.3mol / h to absorb hydrogen chloride and sulfur dioxide gas;

[0042] S3. The reaction solution is discharged from the bottom of the r...

Embodiment 3

[0044] Embodiment 3: a kind of green production method of levetiracetam key intermediate S-2-aminobutyric acid methyl ester comprises the following steps:

[0045] S1. Will S -2-aminobutyric acid and methanol in a molar ratio of 1:5, S -Pump 2-aminobutyric acid and thionyl chloride into reactor 1 at a molar ratio of 1:2, heat to a reaction temperature of 30°C, and vigorously stir for 10 hours, and the hydrogen chloride and sulfur dioxide produced by the reaction are extracted from the top of reactor 1;

[0046] S2. The hydrogen chloride and sulfur dioxide extracted from the top of the reactor 1 are pumped into the bottom of the gas absorption tower 2, and the top of the gas absorption tower 2 is pumped into an alkaline aqueous solution, and the top of the tower is pumped into an aqueous sodium bicarbonate solution at a flow rate of 0.5mol / h to absorb hydrogen chloride and sulfur dioxide gas;

[0047] S3. The reaction solution is discharged from the bottom of the reaction ket...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a green production method of a levetiracetam key intermediate S-2-methyl aminobutyrate, and belongs to the field of medicine preparation, the method comprises the following steps: S1, pumping a mixture of S-2-aminobutyric acid, methanol and thionyl chloride into a reaction kettle, heating and stirring for reaction, and extracting the hydrogen chloride and the sulfur dioxidegenerated by reaction from the top of the reaction kettle; s2, pumping the hydrogen chloride and the sulfur dioxide extracted from the top of the reaction kettle into the bottom of an absorption tower, and pumping an alkaline aqueous solution into the tower top to absorb the hydrogen chloride and sulfur dioxide gas; and S3, discharging the reaction liquid from the bottom of the reaction kettle, and carrying out atmospheric distillation to obtain the S-2-methyl aminobutyrate. According to the process method provided by the invention, the hydrogen chloride and the sulfur dioxide generated in the production process of the S-2- methyl aminobutyrate are effectively absorbed, so that the process is greener and more environment-friendly, and meanwhile, the conversion rate of the S-2-methyl aminobutyrate in the obtained reaction product is greater than 88%.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a key intermediate of levetiracetam S - Green production method and device for methyl 2-aminobutyrate. Background technique [0002] Levetiracetam is a pyrrolidone compound with the trade name Keppra. It applied for a preparation method patent in China in 1985, and was approved to be marketed in Europe in 1999. In April 2000, it was approved by FDA to be marketed in the United States. In March 2007, it was listed in China. Later, it was found in preclinical pharmacological experiments that it has a unique Antiepileptic effect. In addition to being used as adjuvant therapy for intractable epilepsy, its indications have also been gradually extended to monotherapy for newly diagnosed epilepsy, which has broad application prospects. Currently the only antiepileptic drug with unique properties to prevent epilepsy. In recent years, the production process of levetiracetam has alw...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C227/40C07C229/08B01J19/18B01D53/78B01D53/50B01D53/68
CPCC07C227/18C07C227/40B01J19/18B01D53/78B01D53/501B01D53/68C07B2200/07B01D2251/306B01D2251/606C07C229/08
Inventor 凌岫泉陶义华穆加兵
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap