Processing technique of L-2-amino butyramide hydrochloride

A technology of aminobutyramide and processing technology, which is applied in the field of medicine and chemical industry, can solve the problems of product purity not meeting the requirements of customers, unacceptable production cost, high temperature and pressure, etc., and achieve low cost, easy control of reaction, and equipment requirements low effect

Inactive Publication Date: 2016-12-07
ABA CHEM NANTONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] (1) Butyric acid is brominated to obtain 2-aminobutyric acid. This route uses butyric acid as a raw material, replaces the hydrogen on a with bromine, then adds ammonia water to replace the bromine atom, and obtains the target product; the by-product HBr is generated in this reaction Gas, and bromine is used, and the workshop production environment is poor; in addition, because butyric acid has 3 hydrogen atoms at a, Br can replace 2 or even 3 hydrogen atoms at the a position at the same time, resulting in difficult separation of the final product, and the purity of the product reaches Less than the customer's use requirements
[0007] (2) Using methionine as raw material to di

Method used

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  • Processing technique of L-2-amino butyramide hydrochloride

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Embodiment 1

[0023] The processing technology of present embodiment L-2-aminobutanamide hydrochloride, the specific steps of this processing technology are as follows:

[0024] (1) Add 2-chlorobutyric acid and hexamethylenetetramine into the reaction vessel, and stir evenly at room temperature to obtain a feed solution. The mass molar ratio of 2-chlorobutyric acid and hexamethylenetetramine is 1:0.2 ;

[0025] (2) Pass liquid ammonia into the feed liquid in step (1), the mass molar ratio of liquid ammonia usage to 2-chlorobutyric acid is 3:1, the reaction is carried out in the water phase, and the reaction temperature is controlled at 40°C. The reaction time is 20 hours;

[0026] (3) After the reaction in step (2), use the difference in the solubility of 2-aminobutyric acid and ammonium chloride in water, add water to dissolve, ethanol analysis, and suction filter to obtain 2-aminobutyric acid;

[0027] (4) Split 2-aminobutyric acid in step (3) with L-tartaric acid to obtain L-2-aminobut...

Embodiment 2

[0030] The processing technology of present embodiment L-2-aminobutanamide hydrochloride, the specific steps of this processing technology are as follows:

[0031] (1) Add 2-chlorobutyric acid and hexamethylenetetramine into the reaction vessel, and stir evenly at room temperature to obtain a feed solution. The mass molar ratio of 2-chlorobutyric acid and hexamethylenetetramine is 1:0.5 ;

[0032] (2) Pass liquid ammonia into the feed liquid in step (1), the mass molar ratio of liquid ammonia usage to 2-chlorobutyric acid is 4:1, the reaction is carried out in the water phase, and the reaction temperature is controlled at 60°C. The reaction time is 4 hours;

[0033] (3) After the reaction in step (2), use the difference in the solubility of 2-aminobutyric acid and ammonium chloride in water, add water to dissolve, ethanol analysis, and suction filter to obtain 2-aminobutyric acid;

[0034] (4) Split 2-aminobutyric acid in step (3) with L-tartaric acid to obtain L-2-aminobuty...

Embodiment 3

[0037] The processing technology of present embodiment L-2-aminobutanamide hydrochloride, the specific steps of this processing technology are as follows:

[0038] (1) Add 2-chlorobutyric acid and hexamethylenetetramine into the reaction vessel, and stir evenly at room temperature to obtain a feed solution. The mass molar ratio of 2-chlorobutyric acid and hexamethylenetetramine is 1:0.3 ;

[0039] (2) Pass liquid ammonia into the feed liquid in step (1), the mass molar ratio of liquid ammonia usage to 2-chlorobutyric acid is 3.5:1, the reaction is carried out in the water phase, and the reaction temperature is controlled at 50°C. The reaction time is 12 hours;

[0040] (3) After the reaction in step (2), use the difference in the solubility of 2-aminobutyric acid and ammonium chloride in water, add water to dissolve, ethanol analysis, and suction filter to obtain 2-aminobutyric acid;

[0041] (4) Split 2-aminobutyric acid in step (3) with L-tartaric acid to obtain L-2-aminob...

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Abstract

The invention relates to a processing technique of L-2-amino butyramide hydrochloride. The processing technique includes: using 2-chlorobutyric acid as a raw material and hexamethylenetetramine as a catalyst to prepare 2-aminobutyric acid; using L-tartaric acid to resolve 2-aminobutyric acid to obtain L-2-aminobutyric acid, acrylating L-2-aminobutyric acid to obtain L-2-aminobutyryl compound, and obtaining L-2-amino butyramide hydrochloride under the condition of ammonia water. The processing technique has the advantages that by the processing technique, reaction yield is increased, and byproducts are few. In addition, the processing technique is mild in reaction condition, easy in reaction control, low in cost, high in yield, high in product purity, low in equipment requirement and suitable for industrial production, and technique safety is improved greatly.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to a production method of a pharmaceutical intermediate [0002] method, in particular to a processing technology of L-2-aminobutyramide hydrochloride. Background technique [0003] Epilepsy is a chronic recurrent short-term brain dysfunction syndrome caused by a variety of etiologies. The long-term recurrent seizures of the disease seriously affect the patient's quality of life and social work ability, causing great harm to individuals and society. Levetiracetam, chemical name (s)-a-ethyl-2-oxo-1-pyrrolidineacetamide, is a new type of antiepileptic drug developed by UCB Company in Belgium. Etiracetam has the characteristics of high therapeutic index, high safety index, can be used for monotherapy, does not interact with other antiepileptic drugs, has mild side effects, good tolerance, and excellent pharmacokinetic indexes. The only antiepileptic drug with unique proper...

Claims

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Application Information

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IPC IPC(8): C07C231/02C07C237/06
CPCC07C231/02C07C227/08C07C227/34C07C237/06C07C229/08
Inventor 牛跃辉吴争光吕剑
Owner ABA CHEM NANTONG
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