Processing technique of L-2-amino butyramide hydrochloride

Abstract

The invention relates to a processing technique of L-2-amino butyramide hydrochloride. The processing technique includes: using 2-chlorobutyric acid as a raw material and hexamethylenetetramine as a catalyst to prepare 2-aminobutyric acid; using L-tartaric acid to resolve 2-aminobutyric acid to obtain L-2-aminobutyric acid, acrylating L-2-aminobutyric acid to obtain L-2-aminobutyryl compound, and obtaining L-2-amino butyramide hydrochloride under the condition of ammonia water. The processing technique has the advantages that by the processing technique, reaction yield is increased, and byproducts are few. In addition, the processing technique is mild in reaction condition, easy in reaction control, low in cost, high in yield, high in product purity, low in equipment requirement and suitable for industrial production, and technique safety is improved greatly.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to a production method of a pharmaceutical intermediate [0002] method, in particular to a processing technology of L-2-aminobutyramide hydrochloride. Background technique [0003] Epilepsy is a chronic recurrent short-term brain dysfunction syndrome caused by a variety of etiologies. The long-term recurrent seizures of the disease seriously affect the patient's quality of life and social work ability, causing great harm to individuals and society. Levetiracetam, chemical name (s)-a-ethyl-2-oxo-1-pyrrolidineacetamide, is a new type of antiepileptic drug developed by UCB Company in Belgium. Etiracetam has the characteristics of high therapeutic index, high safety index, can be used for monotherapy, does not interact with other antiepileptic drugs, has mild side effects, good tolerance, and excellent pharmacokinetic indexes. The only antiepileptic drug with unique proper...

AI Technical Summary

Problems solved by technology

[0006] (1) Butyric acid is brominated to obtain 2-aminobutyric acid. This route uses butyric acid as a raw material, replaces the hydrogen on a with bromine, then adds ammonia water to replace the bromine atom, and obtains the target product; the by-product HBr is generated in this reaction Gas, and bromine is used, and the workshop production environment is poor; in addition, because butyric acid has 3 hydrogen atoms at a, Br can replace 2 or even 3 hydrogen atoms at the a position at the same time, resulting in difficult separation of the final product, and the purity of the product reaches Less than the customer's use requirements

[0007] (2) Using methionine as raw material to directly generate 2-aminobutyric acid through desulfurization methylation, the process route is simple, but it is unacceptable due to its generation cost

[0008] (3) Synthesis of 2-aminobutyric acid by seaweed method, using n-propionaldehyde as raw material to react with ammonium bicarbonate and sodium cyanide to form seaweed, hydrolyzed under pressurized alkaline conditions to obtain sodium 2-aminobutyrate, and use Adjust the pH to the equivalence point with hydrochloric acid to obtain 2-aminobutyric acid; when the hydrangea is hydrolyzed, the temperature and pressure are high, there are safety hazards, and a large amount of ammonia gas is released, and the cost of desalination is high

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