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Juglans mandshurica husk extractive and preparation method thereof

A technology of walnut bark and extract, which is applied in the field of walnut bark extract-cateselin and its preparation, and can solve problems such as easy recurrence

Inactive Publication Date: 2012-02-15
DANDONG MEDICINE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are two main methods of treating liver diseases in Western medicine: one is to use drugs that can inhibit virus replication, such as interferon, lamivudine, etc. These drugs are highly symptomatic and have obvious therapeutic effects, but they are prone to relapse after drug withdrawal , and sometimes even turn into irreversible serious consequences

Method used

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  • Juglans mandshurica husk extractive and preparation method thereof
  • Juglans mandshurica husk extractive and preparation method thereof
  • Juglans mandshurica husk extractive and preparation method thereof

Examples

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Effect test

Embodiment 1

[0017] The preparation method of walnut catalpa bark extract is to get walnut catalpa bark 100kg and grind into 50-60 mesh coarse powder (or break into small pieces), add 6-8 times of drinking water, heat and extract three times, the temperature is 100 ℃, each time After 3 hours, filter, concentrate under reduced pressure at 50-60°C to a mother liquor containing 0.5-1g of medicinal material per 1ml, separate and purify with a macroporous adsorption resin, and obtain 200mg of brown-yellow walnut bark extract oil, with a yield of 2‰.

Embodiment 2

[0019] The preparation method of walnut catalpa bark extract is to get walnut catalpa bark 100kg and grind into 40-50 order coarse powder (or be broken into fritters), add 6 times of amount ethanol, ethanol concentration is 70%, heating and refluxing three times, heating temperature is 80-90°C, 1 hour each time, filter, concentrate under reduced pressure at 50-60°C to the mother liquor containing 0.5-1g of medicinal materials per 1ml, separate and purify by macroporous adsorption resin, and obtain 200mg of brown-yellow walnut bark extract oil , the yield is 2‰.

Embodiment 3

[0021] The preparation method of walnut catalpa bark extract is to get 100kg of walnut catalpa bark and grind it into coarse powder (or broken into small pieces), add 7 times the amount of ethanol, the ethanol concentration is 80%, heating and refluxing three times, the heating temperature is 80-90 ℃ , filtered for 1 hour each time, concentrated under reduced pressure at 50-60°C to a mother liquor containing 0.5-1g of medicinal material per 1ml, separated and purified by macroporous adsorption resin, to obtain 250mg of brown-yellow walnut bark extract oil, with a yield of 2.5‰.

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Abstract

The invention relates to a juglans mandshurica husk extractive which contains the main medical active ingredients of 8-hydroxyl-9,10-anthraquinone-1-carboxylic acid, REG IOLONE, 4,5,8- trihydroxy-alpha-naphthyl ketone-3-O-beta-D-glucopyranoside, 4,5,8- trihydroxy-alpha- naphthyl ketone-3-O-(6'-O- nutgall acyl)-beta-D- glucopyranoside, 1-(4'- hydroxyl phenyl)-7-(3''-methoxy-4''-hydroxyl phenyl) heptane-3-alcohol, 4-hydroxy-2,6- syringol-1-O-beta-D-glucopyranoside, 4- hydroxyl-2,6- syringol-1-O-(6'-O- nutgall acyl)-beta-D- glucopyranoside, vanillic acid-4-O-(6'-O- nutgall acyl)-beta-D-glucopyranoside, vanillic aldehyde, vanillic acid, gallic acid, syringic acid, kaempferol, quercetin glycoside, myrica rubra and quercetin. The juglans mandshurica husk extractive has good effect in curing hepatopathy and restraining the growth of tumor and especially has the effect of directly killing the hepatocarcinoma cells.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a walnut and catalpa bark extract - catalpatin and a preparation method thereof. Background technique [0002] Walnut catalpa (Juglans mandshurica Maxim) is a deciduous tree of the Juglandaceae Juglans genus. It is an important companion tree species in the Northeast broad-leaved Korean pine forest and one of the three famous hard broads in Northeast China. It is mainly distributed in Northeast China. Walnut catalpa is a precious and protected plant in my country. [0003] In recent years, the incidence of liver disease accounts for the first place in statutory reports of various infectious diseases. There are more than 280 million people living with HBV worldwide. my country is a high-incidence area of ​​liver disease. There are more than 93 million hepatitis B virus carriers and more than 10 million patients. More than 25-40% of them develop liver cirrhosis or liver cancer. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P35/00A61P1/16
Inventor 张秀君
Owner DANDONG MEDICINE GROUP
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