The invention belongs to the technical field of microorganisms, and particularly relates to
lysobacter enzymogenes SYSU923 and application thereof. According to the invention, a dominant strain
lysobacter enzymogenes SYSU923 with broad-spectrum bacteriostatic activity is obtained by culturing, separating and purifying a soil sample through a flat plate bacteriostatic zone method, and is identified as
lysobacter enzymogenes through
gram staining, microscopic examination, single
colony morphology observation and
molecular biology experiments, and the
lysobacter enzymogenes SYSU923 can be used for preparing the
lysobacter enzymogenes SYSU923 with broad-spectrum bacteriostatic activity. The
lysobacter enzymogenes SYSU923 or the culture of the lysobacter enzymogenes SYSU923 is combined with the
immune checkpoint inhibitor to carry out anti-tumor treatment on
esophageal cancer implanted tumor mice, the lysobacter enzymogenes SYSU923 is found to have a remarkable effect in the aspect of enhancing the
treatment effect of the
immune checkpoint inhibitor, and through
combined treatment, the in-situ growth of tumors can be effectively inhibited; the
metastasis of
tumor cells is also remarkably reduced, and a more
effective treatment strategy is expected to be provided for
esophageal cancer patients.