24 results about "Flavonoid derivatives" patented technology

The present invention discloses a dandelion flavonoid derivative, its preparation method, and application. The dandelion flavonoid derivative has the following molecular structure: The dandelion flavonoid derivative provided by the present invention has anti-inflammatory and lung nodule-removing effects, is simple to prepare, and has good biocompatibility, making it a promising new drug for eliminating lung nodules.

The invention relates to a flavonoid derivative containing a flavonoid that is coupled to an alkylene group via an ether bond, said alkylene group having an adhesion group for adhesion onto a dental surface. The flavonoid derivative has a long-term suppressing effect on the dental disease-causing formation of biofilm on the dental surfaces treated with the flavonoid derivative. The invention further relates to a kit for producing such a flavonoid derivative, and to the use of same.

The invention discloses a colorimetric array sensing analysis method for identifying a flavonoid antioxidant, belongs to the technical field of detection, and particularly relates to a flavonoid antioxidant identification technology. The method disclosed by the invention is based on NiCo-LDH, H2O2 is introduced to construct a reaction system of three different chromogenic substrates, and five flavonoid antioxidants are identified by a colorimetric array sensing method. The method and colorimetric array sensing have the characteristic of high throughput, can detect a plurality of samples at the same time, greatly improve the detection efficiency, quickly screen the flavonoid derivatives with high antioxidant activity, lay a foundation for drug research and development and product development, and show better prospects in the fields of medicine, food science and the like.

The invention discloses a flavone derivative delivery system of targeted EGFR (Epidermal Growth Factor Receptor) protein as well as a preparation method and application of the flavone derivative delivery system, and belongs to the technical field of medicinal chemistry. The flavonoid derivative HT11 with anti-A beta and antioxidant activity is synthesized firstly, the depolymerization effect of the flavonoid derivative HT11 on A beta 1-42 reaches up to 92.40%, and the flavonoid derivative HT11 has good blood-brain barrier permeability. Then, the HT11 is loaded by taking the graphene oxide quantum dot as a carrier to obtain the HT11 coated GOQDs, so that the defect of low solubility of the HT11 is effectively overcome, and the targeting property and the curative effect of the HT11 coated GOQDs can be enhanced. Experimental results show that the HT11-coated GOQDs effectively solve the problem of reduction of AD animal space learning and memory ability, and possibility is provided for application of the HT11-coated GOQDs in the field of biological medicine.

Provided are a pharmaceutical composition for preventing, ameliorating or treating atopic diseases comprising a flavonoid derivative as an active ingredient, and a method for preparing the flavonoid derivative, and more specifically, provided are a pharmaceutical composition for preventing, ameliorating or treating atopic diseases comprising a flavonoid derivative 3, 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ' The invention relates to a pharmaceutical composition containing 3, 4-dihydroxyflavonol as an active ingredient and a method for preparing the 3, 4-dihydroxyflavonol.

The invention relates to a process for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, comprising the following successive steps: a) Mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component to form a solution of polylactide-co-glycolide in an organic solvent, to form a water-oil emulsion; b) Mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer, to form a water-oil-water emulsion, c) Mixing the water-oil-water emulsion with an aqueous salt solution; d) Removal of the organic solvent in the water-oil-water emulsion to form a suspension comprising the microparticles loaded with at least the flavonoid and / or flavonoid derivative; e) Separating the loaded microparticles from the liquid of the suspension. Furthermore, the invention relates to microparticles, the use of which for the manufacture of a medicinal product, a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, as well as non-medical use in cosmetics.

The present invention discloses a class of flavonoid derivatives, their preparation methods, and applications. The structural formula is shown in Formula I: wherein X is selected from CH and N, and R1 is selected from H. These compounds can significantly inhibit the activation of STAT3, a cell signaling pathway, at low doses. Experimental results show that these compounds can significantly inhibit the proliferation of various tumor cell lines, including lymphoma, multiple myeloma, cervical cancer, breast cancer, gastric cancer, lung cancer, and pancreatic cancer. They can specifically inhibit STAT3 signaling activation and the expression of the downstream target gene cyclinD1, indicating that these compounds have the potential to be developed as targeted anti-tumor drugs related to the STAT3 signaling pathway.

The invention relates to a method for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, having the following steps which are carried out one after the other: a) mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component in order to form a solution of polylactic acid-co-glycolide in an organic solvent in order to form a water-oil emulsion; b) mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer in order to form a water-oil-water emulsion; c) mixing the water-oil-water emulsion with an aqueous salt solution; d) removing the organic solvent in the water-oil-water emulsion in order to form a suspension which comprises the microparticles loaded at least with the flavonoid and / or flavonoid derivative; and e) separating the loaded microparticles from the liquid of the suspension. The invention also relates to microparticles, to the use thereof for producing a medicament, to a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, and to the non-medical use thereof in cosmetics.

The invention discloses a process for synthesizing methylated flavonoids derivatives by utilizing a photocatalysis technology, which comprises the following steps: firstly, placing flavonoids derivatives in a glass test tube, then adding dimethyl sulfoxide (DMSO) as a methyl donor and a solvent, and adopting eosin Y as a photocatalyst to synthesize the methylated flavonoids derivatives. And 1-azabicyclo [2.2. 2] octane (quinuclidine) is added as an alkaline additive. Under the condition of room temperature, a blue light source with the power being 18 watts and the wavelength being 455 nanometers is used for carrying out illumination stirring reaction. And separating and purifying the crude product to obtain the 3-methyl flavonoid derivative. The invention realizes a photochemical C-H alkylation reaction of dimethyl sulfoxide and flavonoid derivatives, a series of functionalized methylated flavonoid derivatives can be constructed through simple operation, and compared with the traditional synthesis method, the method has the main advantages that: 1) the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the method has the advantages of simple operation, no need of metal catalysts and strong oxidants, no need of strong acids, simple operation, no need of nitrogen protection, high yield and good tolerance of functional groups.

The present invention relates to the field of pharmaceutical chemistry, and discloses flavonoid derivatives, preparation methods thereof, pharmaceutical compositions, and applications thereof. The general structural formula of the flavonoid derivatives is: wherein R2 and R'2 are independently selected from -H, -OH, or -OCH3; R3 and R'3 are independently selected from -H, -CH3, -OCH3, -CH(CH3)2, or -CH(CH2)2; R5 and R'5 are independently selected from -H, -CH3, -OCH3, -CH(CH3)2, or -CH(CH2)2; R6 and R'6 are independently selected from -H, -OH, or -OCH3. The flavonoid derivatives have enhanced lipid solubility, facilitate BBB penetration, increase drug concentration in the brain, maintain pharmacokinetic levels, effectively retain neuroprotective effects such as anti-oxidative stress, anti-inflammatory, and neuroregeneration, and introduce propofol into the flavonoid skeleton to enhance the anesthetic effect under the synergistic effect of the two, making them a potential new antidepressant drug.

The present invention discloses a flavonoid derivative and a preparation method and application thereof, relating to the technical field of pharmaceutical chemistry. The flavonoid derivative comprises a chrysin derivative or a baicalein derivative. The general structural formula of the chrysin derivative is shown in Formula I-1, and the general structural formula of the baicalein derivative is shown in Formula I-2. The results show that the compound 2-phenyl-5-hydroxy-7-((6-(4-methoxypiperidine-1)-2-methylpyrimidin-4-yl))oxy)-4H-chromene-4-one (BY6) has significant cytotoxic activity (IC) against A549 cell lines. 50 :14.70μM), with higher inhibitory activity than cisplatin; and the best cytotoxic activity against PC‑3 cell line (IC 50 :9.18μM), and its inhibitory activity was comparable to that of cisplatin; its inhibitory activity against HCT116 cell line was comparable to that of cisplatin (IC 50 :19.47 μM).

The utility model relates to essence sampling technical field discloses a kind of white orchid flavone derivative whitening essence sampling equipment, including sampling cylinder main part and protective shell, the output shaft of electric push rod is fixed with rubber plug block, the lower portion of hose is equipped with sleeve, the lower end outer wall of hose is sleeved with collar, the outer wall of sleeve is sleeved with locating ring, the inner wall of locating ring is embedded with magnetic sheet two, the outer wall of collar is embedded with magnetic sheet one, the utility model is provided with locating ring, convex strip, collar, guide strip, sleeve and push column, first push locating ring along the convex strip of sleeve outer wall inlaying sliding when operating, accurately remove it to target sampling scale position of scale table, collar is driven along sleeve inner wall stable sliding by push column, when collar slides to the corresponding position of locating ring, magnetic sheet two and magnetic sheet one produce adsorption force, simultaneously, dismounting link does not need to be assisted by tool, guarantee the accuracy of subsequent whitening active ingredient detection result.

The present invention relates to the technical field of medicine, and in particular relates to a class of compounds containing a nitric oxide (NO) donor or a pharmaceutically acceptable salt, a preparation method therefor, a pharmaceutical composition thereof, and the use thereof in the treatment or prevention of ocular-hypertension-related diseases and optic nerve injury related diseases.

The invention belongs to the technical field of natural pharmaceutical chemistry, and discloses a flavonoid derivative in dalbergia odorifera and a preparation method and application thereof.The flavonoid derivative is separated from dalbergia odorifera of leguminous dalbergia plant, dalbergia odorifera heartwood is extracted and concentrated to obtain extract, the extract is separated through silica gel column chromatography and gel column chromatography, and the flavonoid derivative is obtained. And performing semi-preparative high performance liquid chromatography purification to obtain the flavonoid derivative. An inflammation model is established by inducing RAW 264.7 cells through lipopolysaccharide (LPS), and it is proved that the compound has good anti-inflammatory activity and can be used for preparing anti-inflammatory drugs.

The invention relates to compounds and their therapeutic use, said compounds having the formula (I) wherein, for example, wherein, for example, • α is 0, • δ is 0, • X is O, • V is H2C=O, • n is 1 and m is 0, • R1 is a hydrogen atom, • R2 is a methyl group and R3 is -OH, • Z is (A1).

The invention discloses a novel flavonoid derivative and a composition for improving pulmonary fibrosis prepared by using the same, the flavonoid derivative has an effect of inhibiting EMT by inhibiting a TGF-beta1 signal transduction pathway, and has no special cytotoxicity to A549 cells derived from lung cancer, Hulec-5a cells derived from pulmonary blood vessels and human lung fibroblasts (HLF). The expression of pulmonary fibrosis related factors in A549 cells and Hulec-5a cells which are treated by EGF (Epidermal Growth Factor) or bleomycin to cause pulmonary fibrosis can be regulated.

Use of a flavonoid derivative of formula I or a salt thereof in preparing a medicament for preventing and / or treating sarcopenia. The chemical structural formula of formula I is as follows, wherein R1 and R2 are monosaccharides or oligosaccharides composed of glucose (glc) and / or rhamnose (rha) combined in different amounts and manners.

The invention discloses a multi-effect corrosion and scale inhibition water treatment agent and a preparation method thereof, modified tannic acid extracted from agricultural waste camellia oleifera shells and hydroxyapatite nano powder prepared from industrial tailings are taken as cores, and camellia oleifera shell flavonoid derivatives are compounded. The three components cooperate to realize the functions of corrosion inhibition, scale inhibition, biological inhibition, biofilm resistance and silicon scale resistance, the pathogenic bacterium inhibition rate is 98-99.5%, the silicon scale inhibition rate is 90-94%, and the biodegradation rate is 95-98%. A one-step in-situ composite process is adopted, mineral powder generation and tannic acid extraction are synchronously completed, energy consumption is reduced by 35%-45%, the product storage period is 18 months, waste is treated with waste, phosphorus pollution is avoided, and the method is suitable for high-silicon complex water quality.

The invention discloses a synthetic method of a natural product flavonoid compound, and belongs to the technical field of synthesis of flavone derivatives, the synthetic method comprises eight specific steps, the synthetic method adopts an artificial synthesis method to synthesize the flavonoid compound 6-methoxyl-4 ', 5, 6'-tetramethyl-4 ', 5'-tetramethyl-4 ', 5'-tetramethyl-4 ', 5'-tetramethyl-4 ', 5'-tetramethyl-4 '-tetramethyl-4', 5 '-tetramethyl-4' Compared with the prior art, the method provided by the invention has the advantages of high yield and low cost, and can replace the method for separating and preparing the compound from the plant, and the method provided by the invention can be used for preparing the compound from the plant in the presence of the 2, 3, 7-trihydroxy-8-(1 ''-(3'' '-methoxyl-4 '''-hydroxyphenyl) ethyl) isoflavone.

This invention relates to the fields of chemistry and pharmaceutical compounds, specifically to a coumarin-flavonoid derivative, its preparation method, and its applications. The coumarin-flavonoid derivative is a compound with the structure shown in Formula I, or a pharmaceutically acceptable salt, solvent compound, enantiomer, diastereomer, tautomer, or mixture thereof in any proportion; wherein n is an integer from 5 to 11; and X is any one of Cl, Br, and I. This compound exhibits good antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, with high yield and low cytotoxicity. Formula I

The invention discloses an iodinated flavone derivative electrochemical synthesis method, which comprises: adding a flavone derivative, potassium iodide and a solvent into an unseparated electrolytic bath, using a graphite rod as an anode and a platinum sheet as a cathode, stirring under the current condition of 10 milliamperes, and separating and purifying a reaction crude product to obtain the iodinated flavone derivative. The invention develops an electrochemical C-H iodination reaction of potassium iodide and flavone derivatives, a series of functionalized iodinated flavone derivatives can be constructed through simple operation, and compared with the traditional synthesis method, the method has the main advantages that: 1) the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the method has the advantages of simple operation, no need of nitrogen protection, no use of a chemical oxidant due to the fact that an electric oxidation method is used in the reaction, good tolerance of functional groups, high yield and short reaction time.

The invention discloses a wheat flavone derivative derived from spartina alterniflora and a preparation method and application thereof. The wheat flavone derivative has a structural expression shown in the specification, the wheat flavone derivative provided by the invention not only can effectively reduce the blood uric acid level, but also can improve metabolic disorders related to hyperuricemia, such as hyperglycemia, hypercholesterol and hypoproteinemia, and has a multi-target effect; .

The present invention relates to novel protoflavonoid and flavonoid derivatives as xanthine oxidase inhibitors of formula (I), to their preparation and therapeutic application.

The application belongs to the technical field of natural medicine chemistry, and discloses flavone derivatives in Jinyunhuang, and a preparation method and application thereof.The flavone derivatives are separated from Jinyunhuang of the plant Dalbergia hupeana, and the heartwood of Jinyunhuang is extracted and concentrated to obtain extractum, the extractum is separated by silica gel column chromatography, gel column chromatography, and semi-preparative high performance liquid chromatography, and the flavone derivatives can be obtained.The application establishes an inflammation model by inducing RAW 264.7 cells with lipopolysaccharide (LPS), and confirms that the compound has good anti-inflammatory activity and can be used for preparing anti-inflammatory drugs.