5 results about "Flavonoid derivatives" patented technology

The invention relates to a process for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, comprising the following successive steps: a) Mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component to form a solution of polylactide-co-glycolide in an organic solvent, to form a water-oil emulsion; b) Mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer, to form a water-oil-water emulsion, c) Mixing the water-oil-water emulsion with an aqueous salt solution; d) Removal of the organic solvent in the water-oil-water emulsion to form a suspension comprising the microparticles loaded with at least the flavonoid and / or flavonoid derivative; e) Separating the loaded microparticles from the liquid of the suspension. Furthermore, the invention relates to microparticles, the use of which for the manufacture of a medicinal product, a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, as well as non-medical use in cosmetics.

The invention relates to a method for producing microparticles loaded with at least one flavonoid and / or flavonoid derivative, having the following steps which are carried out one after the other: a) mixing a water component in the form of an aqueous solution comprising the at least one flavonoid and / or flavonoid derivative with an oil component in order to form a solution of polylactic acid-co-glycolide in an organic solvent in order to form a water-oil emulsion; b) mixing the water-oil emulsion from step a) with another water component in the form of an aqueous solution comprising at least one stabilizer in order to form a water-oil-water emulsion; c) mixing the water-oil-water emulsion with an aqueous salt solution; d) removing the organic solvent in the water-oil-water emulsion in order to form a suspension which comprises the microparticles loaded at least with the flavonoid and / or flavonoid derivative; and e) separating the loaded microparticles from the liquid of the suspension. The invention also relates to microparticles, to the use thereof for producing a medicament, to a dispersion containing the microparticles for use in the treatment and / or prophylaxis of oral infections, and to the non-medical use thereof in cosmetics.

This invention relates to the fields of chemistry and pharmaceutical compounds, specifically to a coumarin-flavonoid derivative, its preparation method, and its applications. The coumarin-flavonoid derivative is a compound with the structure shown in Formula I, or a pharmaceutically acceptable salt, solvent compound, enantiomer, diastereomer, tautomer, or mixture thereof in any proportion; wherein n is an integer from 5 to 11; and X is any one of Cl, Br, and I. This compound exhibits good antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, with high yield and low cytotoxicity. Formula I

The invention discloses an iodinated flavone derivative electrochemical synthesis method, which comprises: adding a flavone derivative, potassium iodide and a solvent into an unseparated electrolytic bath, using a graphite rod as an anode and a platinum sheet as a cathode, stirring under the current condition of 10 milliamperes, and separating and purifying a reaction crude product to obtain the iodinated flavone derivative. The invention develops an electrochemical C-H iodination reaction of potassium iodide and flavone derivatives, a series of functionalized iodinated flavone derivatives can be constructed through simple operation, and compared with the traditional synthesis method, the method has the main advantages that: 1) the reaction condition is mild, and the reaction can be smoothly carried out at room temperature; the method has the advantages of simple operation, no need of nitrogen protection, no use of a chemical oxidant due to the fact that an electric oxidation method is used in the reaction, good tolerance of functional groups, high yield and short reaction time.

The present invention relates to novel protoflavonoid and flavonoid derivatives as xanthine oxidase inhibitors of formula (I), to their preparation and therapeutic application.